purpose. To assess the prevalence of refractive error and visual impairment in school-age children a metropolitan area southern China. methods. Random selection geographically defined clusters was used to identify 5 15 years age Guangzhou. Children 22 were enumerated through door-to-door survey examined 71 schools 19 community facilities from October 2002 January 2003. The examination included acuity measurements, ocular motility evaluation, retinoscopy, autorefraction under cycloplegia...

To assess the efficacy and safety of repeated low-level red-light (RLRL) therapy in myopia control children.Multicenter, randomized, parallel-group, single-blind clinical trial.Two hundred sixty-four eligible children 8 to 13 years age with cycloplegic spherical equivalent refraction (SER) -1.00 -5.00 diopters (D), astigmatism 2.50 D or less, anisometropia 1.50 best-corrected visual acuity (BCVA) 0.0 logarithm minimum angle resolution more were enrolled July August 2019. Follow-up was...

To evaluate longitudinal changes in macular choroidal thickness (mCT) myopic children treated for 1 year with repeated low-level red-light (RLRL) therapy and their predictive value treatment efficacy on myopia control.A secondary analysis of data from a multicenter, randomized controlled trial (RCT; NCT04073238).Myopic aged 8-13 years who participated the RCT at 2 5 sites where mCT measurements were available.Repeated was delivered using home-use desktop light device that emitted 650 nm....

Abstract Background To evaluate the long‐term efficacy and safety of continued repeated low‐level red‐light (RLRL) therapy on myopia control over 2 years, potential rebound effect after treatment cessation. Methods The Chinese myopic children who originally completed one‐year randomised controlled trial were enrolled. Children RLRL‐therapy defined as RLRL‐RLRL group, while those stopped switched to single‐vision spectacle (SVS) in second year RLRL‐SVS group. Likewise, merely wear SVS or...

Axial length (AL) elongation in myopia is considered irreversible. We aimed to systemically report unexpected AL shortening observed a randomized clinical trial (RCT) after repeated low-level red-light (RLRL) therapy. This post hoc analysis of multicenter, single-masked RCT. Two hundred sixty-four myopic children aged 8–13 years allocated RLRL treatment (intervention group) or single vision spectacle (SVS, control were included. was measured using an IOL-master 500 at baseline, 1-, 3-, 6-,...

Myopia is recognized as a progressive eye disease. The aim of this study was to evaluate the frequency and associated factors clinically significant axial length (AL) shortening among myopic children following repeated low-level red light (RLRL) therapy.The clinical data that were collected for aged 3-17 years who received an RLRL therapy delivered by home-use desktop device emitted at 650 nm least 1 year, reviewed. included AL, spherical equivalent refraction (SER), visual acuity measured...

Purpose To examine the prevalence of refractive errors in children aged 3–6 years China. Methods Children were recruited for a trial home-based amblyopia screening kit Guangzhou preschools, during which cycloplegic refractions measured both eyes 2480 children. Cycloplegic refraction (from 3 to 4 drops 1% cyclopentolate ensure abolition light reflex) was by autorefraction and retinoscopy. Refractive defined as followed: myopia (at least −0.50 D worse eye), hyperopia +2.00 eye) astigmatism...

Retinitis pigmentosa (RP) is a rare retinal dystrophy often underrepresented in ophthalmology education. Despite advancements diagnostics and treatments like gene therapy, RP knowledge gaps persist. This study assesses the efficacy of AI-assisted teaching using ChatGPT compared to traditional methods educating students about RP. A quasi-experimental was conducted with 142 medical randomly assigned control (traditional review materials) groups. Both groups attended lecture on completed pre-...

Lycium barbarum L. possesses great salt tolerance and medicinal values, studying its contribute to variety improvement, as well the increase in yield quality. The study integrated tandem mass tags (TMT) phosphoproteomics physiological indexes of exposed different concentrations NaCl, with aim characterizing adaptation characteristics barbarum. findings indicated that a total 2189 differentially phosphorylated peptides were identified, functional analysis revealed their involvement...

PURPOSE. Maintenance of calcium homeostasis is imperative for the clarity lens. Ca 2+ -ATPase essential removal cytosolic calcium, either across plasma membrane or through intracellular organelles such as endoplasmic reticulum. In this study, membranes prepared from clear lens epithelium were compared to cataractous epithelium. METHODS. Human by a protocol utilizing homogenization and centrifugation. activity was measured biochemically using Gamma- 32 P labeled ATP. Lipid order infrared...

Steady-state fluorescence of 6-propionyl-2-(dimethylamino)naphthalene (Prodan) has been employed to study the interacting effects between ethanol and pressure on formation fully interdigitated dipalmitoylphosphatidylcholine (DPPC). At 1 atm 20 degrees C, a dramatic change in emission spectrum Prodan is observed at about 1.1-1.3 M ethanol. The maximum shifts longer wavelengths, intensity ratio 435 nm that 510 nm, F435/F510, decreases abruptly with increasing content. spectral changes are...

The development of myopia is associated with scleral remodeling, but it unclear which factors regulate this process. This study investigated bone morphogenetic protein-2 (BMP-2) expression in the sclera guinea pigs lens-induced (LIM) and after recovery from evaluated effect BMP-2 on extracellular matrix (ECM) synthesis human fibroblasts (HSFs) cultured vitro. Lens-induced was brought about two groups (the groups) by placing -4.00 D lenses right eye for three weeks. left served as a...

To investigate the effect of repeated low-level red-light therapy (RLRLT) on retinal and choroidal blood perfusion in myopic children.Forty-seven children (mean spherical equivalent refractive error [SE]: -2.31 ± 1.26 D; age range: 8.0-11.0 years) were enrolled received RLRLT (power 2 mW, wavelength 650 nm) for 3 min twice a day, while 20 (SE: -2.75 0.84 7.0-10.0 included as control group. All participants wore single-vision distance glasses. Refractive error, axial length (AL) other...

Repeated low-level red-light (RLRL) therapy has been confirmed as a novel intervention for myopia control in children. This study aims to investigate longitudinal changes choroidal structure myopic children following 12-month RLRL treatment.The current is secondary analysis from multicenter, randomized controlled trial (NCT04073238). Choroidal parameters were derived baseline and follow-up swept-source optical coherence tomography scans taken at 1, 3, 6, 12 months. These included the luminal...

The aim of this study was to determine the effect adenosine receptor antagonist 7-methylxanthine (7-MX) on form deprivation myopia in 3-week-old guinea pigs.Two groups pigs were subjected monocular (MD) using a diffuser and fed either 7-MX (300 mg/kg body weight; n = 7) or vehicle control (saline at an equal volume 7-MX; 7). A group (n 6) not deprivation. Ocular refraction, axial length weight measured start after 21 days. thickness posterior sclera by light microscopy collagen fibril...

The aim of this retrospective study was to investigate the relationship between unilateral congenital ptosis in patients older than eight years and their refractive state spherical equivalent refraction (SER).The involved a review clinical records 85 admitted First Affiliated Hospital, Sun Yat-sen University 1998 2010 with ptosis. average age 16.83 (nine 27 years). were classified into mild (27 cases), moderate (37 cases) or severe (21 according degree droopy eyelid covering cornea. fellow...

These data demonstrate that defocus incorporated multiple segment (DIMS) lens reduces myopia progression in children during the first year of use.This study aimed to investigate efficacy DIMS control spectacle Chinese myopic aged 6 15 years.This is a retrospective 1-year longitudinal data. A total 180 were selected from patients at Zhongshan Ophthalmic Center, Sun Yat-sen University, February 2018 January 2021. One group consisted 90 years, with spherical equivalent refraction -0.50 -7.75 D...

The Guangzhou Twin Registry, initiated in 2005, is a population-based registry of twins born between 1987 and 2000. To date, over 9700 pairs twins, regardless their health medical history, were enrolled the database using Official Household Registry City. subsequently verified by door-to-door visits based on address. primary goal this to develop resource for genetic epidemiological studies common diseases southern Chinese population. initial focus distinguish environmental determinants eye...

Acta Ophthalmol. 2010: 88: 759–765 Abstract. Purpose: Recent results have shown that treatment with the non‐selective adenosine antagonist 7‐methylxanthine (7‐MX) reduces development of form deprivation myopia (FDM) in guinea pigs. The aims this study were to identify presence receptors (AdoRs) eye wall pig and determine their possible changes during deprivation. Methods: Three‐week‐old pigs monocularly treated a translucent lens induce FDM. After 21 days, samples taken from posterior...

To determine the effect of 7-methylxanthine (7-MX) on posterior sclera form-deprivation myopia (FDM) in pigmented rabbits.Sixteen rabbits were monocularly deprived (MD) by suturing right eyelids after natural eye opening (ten-day old) for a period 30 days. Two groups fed either 7-MX (30 mg per kg body weight; n=8) or vehicle control (saline equal volume with 7-MX; n=8). Ocular refractions, axial lengths and weights measured at start end experiment days later. Electron microscopy was used to...