A5057197851- Bone Tissue Engineering Materials
- Advanced Glycation End Products research
- Spine and Intervertebral Disc Pathology
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Planarian Biology and Electrostimulation
- Bone Metabolism and Diseases
- Ginger and Zingiberaceae research
- Advanced Sensor and Energy Harvesting Materials
- Diet, Metabolism, and Disease
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Spinal Fractures and Fixation Techniques
- Orthodontics and Dentofacial Orthopedics
- Tissue Engineering and Regenerative Medicine
- Phytochemicals and Antioxidant Activities
- Trace Elements in Health
- Wound Healing and Treatments
- Temporomandibular Joint Disorders
- Hydrogels: synthesis, properties, applications
- Silk-based biomaterials and applications
Chinese PLA General Hospital
2019-2025
Dalian Municipal Central Hospital
2017-2025
Dalian University of Technology
2023-2025
North Carolina Agricultural and Technical State University
2014-2025
Stomatology Hospital
2022-2024
State Council of the People's Republic of China
2024
Shanghai Academy of Spaceflight Technology
2023
Air Force Medical University
2007-2022
State Key Laboratory of Rare Earth Materials Chemistry and Application
2022
Beijing National Laboratory for Molecular Sciences
2022
Alcohol consumption induces liver steatosis; therefore, this study investigated the possible role of adipose tissue dysfunction in pathogenesis alcoholic steatosis. Mice were pair-fed an alcohol or control liquid diet for 8 weeks to evaluate effects on lipid metabolism at tissue-liver axis. Chronic exposure reduced mass and adipocyte size. Fatty acid release from explants was significantly increased alcohol-fed mice association with activation triglyceride lipase hormone-sensitive lipase....
In this study, we investigated the preventive effects of carnosic acid (CA) as a major bioactive component in rosemary extract (RE) on high-fat-diet-induced obesity and metabolic syndrome mice. The mice were given low-fat diet, high-fat diet or supplemented with either 0.14% 0.28% (w/w) CA-enriched RE (containing 80% CA, RE#1L RE#1H), 0.5% 45% RE#2), for period 16 weeks. There was same CA content RE#1H RE#2 diets half amount diet. dietary supplementation significantly reduced body weight...
A main challenge for use of scaffolds in bone engineering involves non-invasive monitoring vivo and enhanced regeneration. The tissue repair effect superparamagnetic iron oxide nanoparticles (SPIONs) was demonstrated previously by our group. However, testing is needed to confirm vitro results. Here, SPIONs loaded gelatin sponge (GS) used as a scaffold (SPIONs-GS) implanted the incisor sockets Sprague–Dawley rats. Incisor filled with nothing GS served controls. Rats were sacrificed at 2 4...
Zinc (Zn) alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions, having a great application potential for repairing bone defect. In this work, hydroxyapatite (HA)/polydopamine (PDA) composite coating was constructed on the surface of Zn-1Mg fabricated laser powder bed fusion, loaded with bioactive factor BMP2 an antibacterial drug vancomycin. The microstructure, degradation behavior, biocompatibility, performance osteogenic...
Abstract The combination of bioactive Zn‐2Mg alloy and additively manufactured porous scaffold is expected to achieve customizable biodegradable performance enhanced bone regeneration. Herein, scaffolds with different porosities, including 40% (G‐40‐2), 60% (G‐60‐2), 80% (G‐80‐2), unit sizes, 1.5 mm (G‐60‐1.5), 2 2.5 (G‐60‐2.5), are by a triply periodic minimal surface design reliable laser powder bed fusion process. With the same size, compressive strength (CS) elastic modulus (EM)...
Recurrent inflammation, intense bacterial infections, and inadequate blood vessel growth make diabetic wounds non-healing. Under pathological environment, cellular functions are also inhibited. In this paper, we developed a novel in situ injectable photo-crosslinking hydrogel embedded with heterojunction Ag@ZnO nanoparticles (NPs) which exhibit dual-channel synergistic ion release reactive oxygen species (ROS) production for anti-bacteria cutaneous regeneration. This platform can be...
A method of employing high-resolution mass spectrometry in combination with vivo metabolite deuterium labeling was developed this study to investigate the effects alcohol exposure on lipid homeostasis at white adipose tissue (WAT)-liver axis a mouse model alcoholic fatty liver. In order differentiate liver lipids synthesized from acids that were transported back and other sources acids, two-stage feeding experiment performed incorporate into metabolites. Hepatic extracted liver, epididymal...
Clinical studies have demonstrated that alcoholics a lower dietary zinc intake compared to health controls. The present study was undertaken determine the interaction between deficiency and ethanol consumption in pathogenesis of alcoholic liver disease. C57BL/6N mice were subjected 8-week feeding 4 experimental liquid diets: (1) adequate diet, (2) diet plus ethanol, (3) deficient (4) ethanol. Ethanol exposure with resulted damage as indicated by elevated plasma alanine aminotransferase level...
Developing a novel antibiotics-free antibacterial strategy is essential for minimizing bacterial resistance. Materials that not only kill bacteria but also promote tissue healing are especially challenging to achieve. Inspired by chemical conversion processes in living organisms, we develop piezoelectrically active device converts ambient O2 and H2O ROS piezocatalytic processes. The achieved mounting nanoscopic polypyrrole/carbon nanotube catalyst multilayers onto piezoelectric-dielectric...
Ferroptosis has been implicated in the pathological process of type 2 diabetic osteoporosis (T2DOP), although specific underlying mechanisms remain largely unknown. This study aimed to clarify role and possible mechanism acid sphingomyelinase (ASM)-mediated osteoblast ferroptosis T2DOP.We treated hFob1.19 cells with normal glucose (NG) different concentrations high (HG, 26.25 mM, 35 or 43.75 mM) for 48 h. We then measured cell viability osteogenic function, quantified autophagy levels,...
Pulsed electromagnetic field (PEMF) stimulation is a prospective non-invasive and safe physical therapy strategy for accelerating bone repair. PEMFs can activate signalling pathways, modulate ion channels, regulate the expression of bone-related genes to enhance osteoblast activity promote regeneration neural vascular tissues, thereby formation during Although their mechanisms action remain unclear, recent studies provide ample evidence effects PEMF on In this review, we present progress...
Abstract Two kinds of hydroxyapatite (HA) with different nanocrystal morphology were obtained via a simple aqueous precipitation method under reactants molar ratios. Under Ca/P ratio 1.67/1, rod‐like crystal was produced, while 1.80/1, spherical produced. The 40–60 nm in diameter, the 40–55 diameter and 79–100 length. influence HA on osteoblasts growth assayed by MTT SEM. results indicated that there significantly higher absorbency value surface assay than latter. In process SEM observation,...
Saponins are one type of widespread defense compound in the plant kingdom and have been exploited for production lead compounds with diverse pharmacological properties drug discovery. Oats contain two unique steroidal saponins, avenacoside A, 1, B, 2. However, chemical composition, levels these saponins commercial oat products, their health effects still largely unknown. In this study, we directly purified 5 (1-5) from a methanol extract bran, characterized structures by analyzing MS NMR...