A5009409725- Bone Tissue Engineering Materials
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Advanced ceramic materials synthesis
- Tissue Engineering and Regenerative Medicine
- Dental Erosion and Treatment
- Innovative concrete reinforcement materials
- Bone and Dental Protein Studies
- Mesenchymal stem cell research
- Polymer Surface Interaction Studies
- Carbon and Quantum Dots Applications
- Endodontics and Root Canal Treatments
- Orthodontics and Dentofacial Orthopedics
- Metal and Thin Film Mechanics
- Facial Trauma and Fracture Management
- Dental Research and COVID-19
- Hedgehog Signaling Pathway Studies
- Nanoparticle-Based Drug Delivery
- Titanium Alloys Microstructure and Properties
- Orthopaedic implants and arthroplasty
- Dental Trauma and Treatments
Nanjing Medical University
2015-2024
Lanzhou University
2021
Southeast University
2010-2016
Nanjing Library
2015
Chongqing University of Posts and Telecommunications
2013
Suzhou Research Institute
2010-2012
Stomatology Hospital
2008-2009
Beijing Hospital
2003
Sichuan University
2002
University of Michigan
2000-2001
Biodegradable synthetic scaffolds hold great promise for oral and craniofacial guided tissue regeneration bone regeneration. To overcome the limitations of current scaffold materials in terms osteogenic antimicrobial properties, we have developed a novel silver-modified/collagen-coated electrospun poly-lactic-co-glycolic acid/polycaprolactone (PLGA/PCL) (PP-pDA-Ag-COL) with improved properties. Our was generated by electrospinning basic PLGA/PCL matrix, followed silver nanoparticles (AgNPs)...
A main challenge for use of scaffolds in bone engineering involves non-invasive monitoring vivo and enhanced regeneration. The tissue repair effect superparamagnetic iron oxide nanoparticles (SPIONs) was demonstrated previously by our group. However, testing is needed to confirm vitro results. Here, SPIONs loaded gelatin sponge (GS) used as a scaffold (SPIONs-GS) implanted the incisor sockets Sprague–Dawley rats. Incisor filled with nothing GS served controls. Rats were sacrificed at 2 4...
One of the key factors in tissue engineering and regenerative medicine is to optimize interaction between seed cells scaffolds such that can grow naturally biomimetic conditions. Their similarity macromolecules many unique properties mean functional nanoparticles have promising potential for modification improvement traditional obtain excellent biocompatibility, tunable stiffness, physical sensing, stimulus-response capabilities. In present study, we report magnetic poly(lactic- co-glycolic...
Literature search revealed no systematic report on iron oxide nanoparticle-incorporating calcium phosphate cement scaffolds (IONP-CPC). The objectives of this study were to: (1) use γFe2O3 nanoparticles (γIONPs) and αFe2O3 (αIONPs) to develop novel IONP-CPC scaffolds, (2) investigate human dental pulp stem cells (hDPSCs) seeding for bone tissue engineering the first time. fabricated. Physiochemical properties characterized. hDPSC cell proliferation, osteogenic differentiation matrix mineral...
Abstract Physical factors in the cellular microenvironment have critical effects on stem cell differentiation. The utilization of physical to promote osteogenic differentiation cells has been established as a new strategy for developing bone tissue engineering scaffolds. In this context, scaffolds with multiscale anisotropy are considered possess biomimetic properties, which advantageous their biological performance. present study, novel magnetic anisotropic hydrogel (MAH) and topographic...
To improve bone regeneration in oral microenvironment, we generated a novel biodegradable, antibacterial, and osteoconductive electrospun PLGA/PCL membrane as an ideal osteogenic scaffold. The three-layer membranes were structured with serial layers of chlorhexidine-doped-PLGA/PCL (PPC), (PP), β-tricalcium phosphate-doped-PLGA/PCL (PPβ). characterize properties these membranes, MC3T3-E1 (MC) cultures seeded onto the for 14 days evaluation cell proliferation, morphology gene/protein...
The topographical features and material composition of scaffolds have a powerful influence on cell behaviors such as proliferation differentiation. Here, consisting aligned fibers with incorporated bioactive collagen I were tested for their ability to enhance osteogenesis in vitro. Rat adipose-derived mesenchymal stem cells (ADSCs) seeded the morphology, proliferation, osteogenic differentiation examined. Aligned showed best properties. Also, adhesion-related genes higher expression I. Our...
Regulating the complex microenvironment after tooth extraction to promote alveolar bone regeneration is a pressing challenge for restorative dentistry. In this study, through modulating mechanical properties of cellular matrix, we guided various types cells by self-organizing form multicellular spheroids (MCSs) and hybridized MCSs with Prussian Blue nanoparticles (PBNPs) in process. The constructed nanohybridized (PBNPs@MCSs) empowered antioxidant functions effectively reduced cell apoptosis...
Abstract In the present study, a novel process has been developed to improve application of single‐walled carbon nanotubes (SWCNTs) in dental resin‐based composites (RBCs). Efforts have made deposit thin shell nano‐SiO 2 onto oxidized surface SWCNTs by using adlayer 3‐aminopropyltriethoxysilane; this was followed modification layer another organosilane with allyl‐terminated functional groups achieve well dispersion and integration matrix. Fourier transform infrared spectroscopy (FTIR)...
This study aimed to investigate and compare the resin bond strengths of zirconia conditioned as follows: alumina sandblasting; sandblasting+application 10-MDP-containing primer; Z-Prime Plus or Metal/Zirconia Primer (new primers); tribochemical silica coating+silanization; hot acid etching in three different combinations [H2SO4/(NH4)2SO4, HF/HNO3, H2SO4/HF/HNO3]+application primer. Shear (SBS) after water storage for 24 h 40 days were measured assess bonding performance. Surface chemical...
The effects of bioactive properties and surface topography biomaterials on the adhesion spreading mouse preosteoblast MC3T3-E1 cells was investigated by preparation different surfaces. Poly lactic-co-glycolic acid (PLGA) electrospun fibers (ES) were produced as a porous rough surface. In our study, coverslips used substrate for immobilization 3,4-dihydroxyphenylalanine (DOPA) collagen type I (COL I) in addition, COL immobilized onto surfaces (E-COL) to investigate combined molecules...
Abstract: Constructing biomimetic structure and incorporating bioactive molecules is an effective strategy to achieve a more favorable cell response. To explore the effect of electrospinning (ES) nanofibrous architecture collagen I (COL I)-incorporated modification on tuning osteoblast response, resorbable membrane composed poly(lactic-co-glycolic acid)/poly(caprolactone) (PLGA/PCL; 7:3 w/w) was developed via ES. COL blended into PLGA/PCL solution prepare composite ES membrane. Notably,...
Blood supply plays a central role in alveolar bone regeneration within large defect filled with cell-laden scaffold material, as it provides sufficient oxygen and nutrition to cells inside the scaffold. To address issue of insufficient vascularization scaffolds designed promote regeneration, we developed pre-vascularized enable repair defects. Peripheral blood-derived mesenchymal stem (PBMSCs) endothelial colony-forming (ECFCs) were collected from peripheral blood incorporated into fibrin...
Introduction: RNA-based therapy for bone repair and regeneration is a highly safe effective approach, which has been extensively investigated in recent years. However, the molecular stability of RNA agents still remains insufficient clinical application. High porosity, tunable size, ideal biodegradability biosafety are few characters mesoporous silicon nanoparticles (MSNs) that render them promising biomaterial carrier treatment. Materials Methods: In this study, novel miR-26a delivery...
A variety of novel biomaterials have recently been developed to promote bone regeneration. However, the current cannot accurately and effectively resist bacterial invasion. In this study, we constructed microspheres that mimic certain functions macrophages as additives repair materials, which can be manipulated demanded bacteria protect defect healing. Firstly, prepared gelatin (GMSs) by an emulsion-crosslinking method, were subsequently coated with polydopamine (PDA). Then, amino...
Epidermal growth factor (EGF) has been shown to induce the migration of various cancer cells. However, underlying signaling mechanisms for EGF-induced oral squamous cell carcinoma (OSCC) remain be elucidated. WNT7A, a member family 19 Wnt secreted glycoproteins, is commonly associated with tumor development. It mostly unknown whether and, if so, how EGF modulates WNT7A in OSCC The role was thus investigated explore OSCC.Cell measured by Wound healing assay and Transwell assay. Western...