A5100655646- Gut microbiota and health
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Adenosine and Purinergic Signaling
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- dental development and anomalies
- Extracellular vesicles in disease
- Peroxisome Proliferator-Activated Receptors
- Barrier Structure and Function Studies
- Curcumin's Biomedical Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Mycorrhizal Fungi and Plant Interactions
- RNA Research and Splicing
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Bacterial Genetics and Biotechnology
- Transplantation: Methods and Outcomes
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Microbial Community Ecology and Physiology
- Bone health and treatments
- Cancer-related molecular mechanisms research
Nanjing University
2024
Nanjing Medical University
2010-2024
Shanghai Stomatological Hospital
2024
Tongji University
2024
Dali University
2022
Nanjing University of Chinese Medicine
2020-2021
Quzhou City People's Hospital
2020
Northwestern University
2019
Neurological Surgery
2019
First Affiliated Hospital of Guangzhou Medical University
2018
Introduction: RNA-based therapy for bone repair and regeneration is a highly safe effective approach, which has been extensively investigated in recent years. However, the molecular stability of RNA agents still remains insufficient clinical application. High porosity, tunable size, ideal biodegradability biosafety are few characters mesoporous silicon nanoparticles (MSNs) that render them promising biomaterial carrier treatment. Materials Methods: In this study, novel miR-26a delivery...
Abstract Background Curcumol was presented to unleash antitumor effects in a variety of cancers, including gastric cancer. However, the relevance between curcumol and cisplatin resistance cancer still remains unclear. Therefore, current research performed survey role sensitivity Methods First, BGC‐823 BGC‐823/DDP cells were incubated with for 48 hr 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) analysis applied determine inhibition rate cell proliferation...
Understanding how microbial communities affect plant growth is crucial for sustainable productivity and ecological health. However, in contrast with the crop system, there limited information on community associated medicinal plant. We observed that altitude was most influential factor soil structures of Aconitum carmichaelii Debeaux. For composition, bacterial reads were assigned to 48 phyla, Proteobacteria, Acidobacteriota, Actinobacteriota being dominant phyla. The fungal seven Ascomycota...
This study aims to investigate the mechanism of K (lysine) acetyltransferase 2A (KAT2A) regulation and control on osteogenic differentiation periodontal ligament stem cells (PDLSCs).The expression levels KAT2A in PDLSCs were compared from each generation normal (H-PDLSCs) periodontitis tissues (P-PDLSCs). The influences gene interference also detected. In addition, canonical Wnt pathway ligands upstream down-stream relationships between determined.The decreased inflammatory tissue was with...
To explore the mechanism of action Fuzheng Yiliu formula (FZYLF) in regulation invasion and metastasis MDA-MB-231/Adr human breast cancer cells through WAVE3.The with high invasive ability were screened by Transwell, plasmid WAVE3 expression was made for transfection. Plasmid transfection efficiency protein level verified polymerase chain reaction (PCR) western blotting (WB). The effect FZYLF on cell proliferation investigated before after silencing flow cytometry. A nude mouse model tumor...
Abstract INTRODUCTION Immunotherapy has failed to improve glioblastoma (GBM) patient survival in all phase III clinical trials to-date. We recently discovered that a combination immunotherapeutic approach simultaneously administers radiation (RT), anti-PD-1 mAb, and an IDO1 enzyme inhibitor resulted long-term of ~40% mice intracranially-engrafted (i.c.) with syngeneic GBM (Ladomersky et al., 2018; CCR). In the same study we benefit depended on non-GBM cells. Our current further interrogates...
Objective To investigate the effects of adenosine 2A receptor (A2AR) on nuclear factor-κB (NF-κB) and inflammatory response in rats with small-for-size liver transplantation.Methods A rat orthotropic transplantation model was established using 35-45% grafts;Recipients were given either A2AR agonist or antagonist.The NF-κB activity ( EMSA),the content phosphorylational IκpB (pIκB) p65 (Western blotting),proinflammatory factors (TNF-α,MIP-2 ICAM-1 ) (ELISA),and MPO analyzed.Results Compared to...
This paper aims to estimate the effect of miR-26a delivered by gold nanoparticles (AuNPs) on gastric cancer (GC) cell growth and invasion. In vitro cultured GC strains SGC-7901 MGC- 803 were processed for transfection miR-26a-mimic, miR-NC, AuNP-ctrl, AuNP-miR-26a groups. MTT, Transwell, flow cytometry employed evaluate groups’ impact vitality, invasion, apoptosis. Western blotting (WB) was used quantify levels apoptosisrelated proteins. addition, solid tumors in mice monitored any changes...