A5028372785- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Vascular Malformations Diagnosis and Treatment
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Pluripotent Stem Cells Research
- Retinal and Optic Conditions
- Retinopathy of Prematurity Studies
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Cell Adhesion Molecules Research
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Surgical Sutures and Adhesives
- CRISPR and Genetic Engineering
- Ocular Disorders and Treatments
- Ocular Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Neonatal and Maternal Infections
- Sirtuins and Resveratrol in Medicine
- Axon Guidance and Neuronal Signaling
Sun Yat-sen University
2013-2025
Nanjing University of Chinese Medicine
2025
He Eye Hospital
2022
Hohai University
2022
Xinjiang Medical University
2022
Zhongshan Ophthalmic Center, Sun Yat-sen University
2007-2019
Wenzhou Medical University
2018-2019
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018
National Natural Science Foundation of China
2007-2016
Doheny Eye Institute
2016
Human induced pluripotent stem cells (iPSCs) provide a valuable model for regenerative medicine and human disease research. To date, however, the reprogramming efficiency of adult is still low. Recent studies have revealed that cell cycle key parameter driving epigenetic to pluripotency. As well known, retroviruses such as Moloney murine leukemia virus (MoMLV) require division integrate into host genome replicate, whereas target primary are mixture several types with different rhythms....
Purpose.: Somatic cells can be reprogrammed into an embryonic stem cell–like pluripotent state by Oct-3/4, Sox2, c-Myc, and Klf4. Sox2 as essential reprogramming factor also contributes to the development of eye retina. This study was conducted determine whether induced (iPS) express retinal progenitor cell (RPC)-related genes iPS directly differentiate ganglion (RGCs). Methods.: Mouse were ectopically expressed four factors in tail-tip fibroblasts (TTFs). The expression RPC-related analyzed...
Abstract Background Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 associated with carcinogenesis and angiogenic process. However, it unclear on the exact role for inducing angiogenesis tumorigeneisis. Method BGC/STC cells (high-expression of STC-1) BGC/shSTC (low- expression were constructed to investigate effect xenograft tumor growth vitro vivo . ELISA assay was used detect vascular endothelial factor (VEGF) supernatants....
ABSTRACT As a novel family of cell surface receptors, triggering receptors expressed on myeloid cells (TREMs) play an important role in inflammatory responses. However, the TREMs ocular immune system remains unknown. In this study, we examined expression and function TREM-1 Pseudomonas aeruginosa keratitis, one most common sight-threatening diseases. was significantly increased human corneas after P. infection. Consistent with at surface, levels (mRNA protein) were also elevated infected...
Hydrogels may be the ideal vitreous substitutes due to their wonderful physical features and biocompatibility. However, drawbacks, short residence time, biodegradation in vivo, have led fact that none of them been approved for clinical use. In this study, we developed a novel approach using foldable capsular body (FCVB) injected with polyvinylalcohol (PVA) hydrogel as substitute long-term tamponade. The 3% PVA was cross-linked by gamma irradiation showed good rheological properties had no...
The natural vitreous body has a fine structure and complex functions. imitation of the by substitutes is challenging work for both researchers ophthalmologists. Gases, silicone oil, heavy oil hydrogels, particularly former two are clinically widely used with certain complications. Those, however, not real artificial due to lack function like body. This article reviews situations, challenges, future directions in development substitutes, experimental clinical use new foldable capsular
To determine the flexibility, efficacy, and safety of a novel foldable capsular vitreous body (FCVB) in treatment severe retinal detachment human eyes.The study involved 11 patients with detachments. A standard three-port pars plana vitrectomy was performed, FCVB triple-folded implanted into cavity. Balanced salt solution then injected capsule to support retina. The treated eyes were examined by ophthalmoscopy, fundus photography, tonometry during 3-month implantation period. B-scan...
The objective of this study was to produce a porcine corneal acellular matrix (ACM) and assess its possibility for biomedical applications.Porcine corneas were treated with various concentrations sodium dodecylsulfate different lengths time. Optimal conditions processing the ACM noted regarding removal all cellular components retention spatial arrangement stroma. physical characteristics (including water absorption light transmittance), biomechanics, cytotoxicity also found be conserved....
Abstract We previously proposed a new strategy to fabricate novel foldable capsular vitreous body (FCVB) as substitute and found that the FCVB was very good replacement for closely mimicking morphology restoring physiologic function of rabbit body. The aim this article assess mechanical, optical, biocompatible properties made from liquid silicone rubber. mechanical show shore hardness is 37.80 degrees, tear strength 47.14 N/mm, tensile more than 7.28 MPa, elongation ratio 1200%; in addition,...
Abstract Purpose To investigate changes in retinal vessel oxygen saturation and diameter high myopia. Methods Relative was measured the blood vessels of 54 participants with myopia compared to a control group individuals emmetropia Oxymap T1 oximeter. The were further divided into two groups according grade myopic retinopathy: Group A (grade < M 2 ) B ≥ ). One‐way anova used analyse mean arterioles venules difference arterio‐venous among four groups. Further analysis multiple comparisons...
purpose. To determine and compare the refractive shifts based on Gullstrand-Emsley Liou-Brennan schematic eyes after filling them with four selected artificial vitreous substitutes: silicone oil, heavy hydrogels, encapsuled balanced salt solution. methods. The optical constants of body–filled were calculated accommodation relaxed. theoretical in these two models compared pars plana vitrectomy (PPV), PPV plus lensectomized intraocular lens (IOL) tamponades. results. eye shows +8.710, −4.544,...
We previously invented a novel foldable capsular vitreous body (FCVB) in the treatment of severe retinal detachment. The purpose this study was to determine its hydrolytic stability vitro and further evaluate efficacy safety human eyes.The test proceeded according State Food Drug Administration guidelines about intraocular lenses ophthalmic implants. A standard three-port pars plana vitrectomy performed, FCVB triple folded sent into cavity three eyes; then silicone oil injected capsule...
To investigate the antioxidative ability of a novel mitochondria-targeted peptide MTP-131 in immortalized human trabecular meshwork (iHTM) and glaucomatous (GTM(3)) cell lines.Cultured iHTM GTM(3) cells were pretreated with for 1 hour, sustained oxidative stress was induced by subjecting TM to 200 μM hydrogen peroxide (H(2)O(2)) 24 hours. Untreated incubated H(2)O(2) alone used as controls. Lactate dehydrogenase (LDH) assay determine viability. Changes mitochondrial membrane potential (ΔΨm)...
Since 300-nm-mili apertures were present in the capsule of foldable capsular vitreous body (FCVB), authors tested whether FCVB could mechanically release dexamethasone sodium phosphate (DexP) from its capsule.In vitro study, DexP at concentrations 0.25, 0.5, 1, 2, and 4 mg/mL a balanced salt solution injected into capsules, which immersed cups modified Franz diffusion cells. Two hundred microliters liquid was aspirated time intervals 10, 20, 40, 60, 120, 180, 240, 300, 360 minutes. In vivo...
A bstract Introduction: The aim of this study was to evaluate over a 180‐day period the biocompatibility and retinal support foldable capsular vitreous body injected with either saline or silicone oil implanted in rabbit eyes. Methods: standard three‐port pars plana vitrectomy performed, bodies were into cavity eyes ( n = 18). Silicone tamponade used as control group 5). Of body‐implanted eyes, 9) retina. treated examined using slit lamp non‐contact slit‐lamp lens, tonopen, specular...
Silicone oil has been the only long-term vitreous substitute used in treatment of retinal detachment since 1962 by Cibis. Nevertheless, its effects on vascular morphology and oxygen supply to retina are ambiguous current research. We previously invented a foldable capsular body (FCVB) use as new severe detachment, but vessel were unknown. Therefore, this study, standard three-port pars plana vitrectomy (PPV) was performed right eye each rabbit then silicone FCVB injected into cavity...
We previously designed a novel foldable capsular vitreous body (FCVB) to treat severe retinal detachment and evaluated its performance in 1-year follow up study. The purpose of this study was determine the efficacy safety silicone oil (SO)-filled FCVB 3-year follow-up.Standard three-port pars plana vitrectomy performed, triple folded implanted cavity three eyes. SO then injected into capsule support retina. eyes were examined using Goldmann applanation tonometry, fundus photography, optical...
<h3>Aim:</h3> To evaluate a new approach of recanalisation nasolacrimal duct obstruction (RC-NLDO) in the treatment (NLDO) and chronic dacryocystitis. <h3>Methods:</h3> 583 patients with 641 eyes suffering from NLDO dacryocystitis were enrolled this study. The RC-NLDO was performed 506 eyes, 135 undergoing external dacryocystorhinostomy (EX-DCR) as controls. Patient follow-up for 54 months evaluated by symptoms, dye disappearance test, lacrimal irrigation digital subtraction dacryocystogram....