A5013078457- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Corneal Surgery and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- FOXO transcription factor regulation
- Synthesis and biological activity
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
First Affiliated Hospital of Xi'an Jiaotong University
2014-2025
Xi'an Jiaotong University
2014-2025
Shanghai Jiao Tong University
2012-2024
Fourth Hospital of Hebei Medical University
2014-2024
Hebei Medical University
2014-2024
Jinan University
2014-2023
State Key Laboratory of Oncogene and Related Genes
2012-2022
Renji Hospital
2012-2022
Shanghai Cancer Institute
2012-2022
Dalian Medical University
2017-2022
The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how looping at locus is regulated remains poorly understood. Here we demonstrate a long noncoding RNA (lncRNA), CCAT1-L, transcribed specifically in colorectal cancers from 515 kb upstream of MYC. This lncRNA plays role transcriptional regulation and promotes looping. Importantly, CCAT1-L located within strong super-enhancer spatially close to Knockdown...
Delivery of therapeutic genes to disseminated tumor sites has been a major challenge in the field cancer gene therapy due lack an efficient vector delivery system. Among various vectors currently available, liposomes have shown promise for systemic distant with minimal toxicity. In this report, we describe improved extruded DOTAP:cholesterol (DOTAP:Chol) cationic liposome that efficiently delivers suppressor p53 and FHIT, which are frequently altered lung cancer, localized human primary...
Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. However, its role in cancer progression remains unknown.Hepatocellular carcinoma (HCC) tissue arrays (n=254) were used to investigate the correlation between MAOA expression clinicopathological findings. In vitro invasion anoikis assays, vivo intrahepatic lung metastasis models determine of HCC metastasis. Quantitative real-time PCR, western...
Hypoxia and dysregulation of microRNAs (miRNAs) have been identified as crucial factors in carcinogenesis. However, the potential mechanisms HIF-1α miR-421 gastric cancer not well elucidated. In this study, we found that was up-regulated by HIF-1α. Overexpression promoted metastasis, inhibited apoptosis, induced cisplatin resistance vivo vitro. E-cadherin caspase-3 were targets miR-421. Besides, relative mRNA expression significantly increased tumor tissues compared with non-tumor a cohort...
Lung cancer remains the leading cause of associated deaths worldwide. Recent efforts have been focused on combinational and nanoparticulate therapies that can efficiently deliver multiple therapeutics. Herein, we reported cetuximab (CET) functionalized, paclitaxel (PTX) 5-Demethylnobiletin (DMN) co-loaded nanostructured lipid carriers (NLCs) (CET-PTX/DMN-NLCs). The morphology, particle size, zeta potential, stability drug release were tested. Cellular uptake, cell viability, synergistic...
Targeting human epidermal growth factor receptor 2 (HER2) therapy is currently considered as the standard treatment for HER2-positive (HER2+) advanced gastric cancer. However, seen in recent clinical trials, most of HER2+ cancer are actually unresponsive to HER2-targeted agents, including lapatinib. The aim this study identify responsible tyrosine kinases (RTK) potentially conferring lapatinib unresponsiveness and elucidate molecular mechanism underlying RTKs-induced resistance.A functional...
Melanoma cell adhesion molecule (MCAM) is a that abnormally expressed in variety of tumours and closely associated with tumour metastasis. The role MCAM ovarian cancer development has not been fully studied. In this study, through immunohistochemical staining tissue samples RNA interference to silence cells, we examined the impact on biological functions cells attempted reveal development. Our results showed expression was particularly high metastatic cancers compared other pathological...
// Xinyang Liu 1, * , Xiaoxiao Ge Zhe Zhang 2 Xiaowei Jinjia Chang 1 Zheng Wu Wenbo Tang Lu Gan Menghong Sun 3 Jin Li 4 Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China Department of Oncology, University Cancer Center, Pathology, Tianyou Hospital Tongji These authors have contributed equally to this work Correspondence to: Li, e-mail: fudanlijin@163.com Keywords: gastric cancer, miR-940, ZNF24, metastasis, epithelial-mesenchymal transition Received: March 23, 2015...
// Congqi Dai 1, * , Fengjuan Lin Ruixuan Geng 1 Xiaoxiao Ge Wenbo Tang Jinjia Chang Zheng Wu Xinyang Liu Ying Zhe Zhang Jin Li 2 Department of Medical Oncology, Fudan University Shanghai Cancer Center; College, University, Shanghai, China Tongji Tianyou Hospital, These authors have contributed equally to this work Correspondence to: Li, e-mail: tianyoulijin@163.com Keywords: PD-L1/PD-1, CIK, NKG2D, immunotherapy, gastrointestinal tumor Received: October 21, 2015 Accepted: January 24, 2016...
Generation of extended- spectrum β- lactamases is one the major mechanisms by which clinical Klebsiella pneumoniae develop resistance to antibiotics. Combined antibiotics prove be a relatively effective method controlling such resistant strains. Some Chinese herbal active ingredients are known have synergistic antibacterial effects. This study aimed investigate effects with cefotaxime on lactamase positive strains pneumoniae, and analyze mechanism action, providing experimental evidence for...
Insulin-like growth factor 2 mRNA binding protein (IGF2BP2) is a member of the IGF2BP family consisting IGF2BP1~3 with capacity to many transcripts and regulating RNA stability, localization, translation. In this study, we discovered that expression IGF2BP2 was upregulated led poor prognosis in pancreatic ductal adenocarcinoma (PDAC). gradually elevated from normal pancreas, intraepithelial neoplasia PDAC an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, demonstrated...
Long non-coding RNA taurine up-regulated gene 1 (TUG1) emerges as new players in regulation several cancers; however, its mechanism of action non-small cell lung cancer (NSCLC) has not been well-studied.Herein, we determined expression pattern TUG1 NSCLC and further identified effect on the chemosensitivity NSCLC.Low was found tissues obtained from non-responders to platinum-based chemotherapy reflected poor overall survival.TUG1 overexpression shown inhibit proliferation, migration,...
Resveratrol is a natural polyphenolic compound with multiple biological effects, e.g., proliferation inhibition, anti-oxidation, and neuroprotection. Besides that, studies have shown that resveratrol inhibits tumor growth migration, as well epithelial-mesenchymal transition (EMT). However, its molecular mechanisms in progression are not fully understood. Nutrient-deprivation autophagy factor-1 (NAF-1) mainly found the endoplasmic reticulum mitochondrial outer membrane. It an important...
Fibroblast growth factor receptor 2 (FGFR2)-targeted therapy has attracted considerable attention as novel anticancer agents in gastric cancer (GC). However, intrinsic or acquired drug resistance emerged a major challenge to their clinical use. In this study, we demonstrated that several tyrosine kinase (RTK), including EGFR, HER3 and MET, activations contributed AZD4547 (a selective FGFR2 inhibitor) hyposensitivity amplified GC cells. The rescue effect was abrogated by inhibiting these RTKs...
Background: Pancreatic cancer poses a significant worldwide health challenge. Immune cells are implicated in pancreatic progression and therapy, yet the precise influence of distinct subsets immune remains largely unexplored. The objective this study is to pinpoint immunophenotypes linked cancer. Methods: Two-sample Mendelian randomization (MR) analysis was employed. phenotypes were retrieved from GWAS, data IEU project split into training validation sets. Causality evaluated using IVW, MR...
The objective of this study was to produce a porcine corneal acellular matrix (ACM) and assess its possibility for biomedical applications.Porcine corneas were treated with various concentrations sodium dodecylsulfate different lengths time. Optimal conditions processing the ACM noted regarding removal all cellular components retention spatial arrangement stroma. physical characteristics (including water absorption light transmittance), biomechanics, cytotoxicity also found be conserved....