A5102918612- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Microstructure and mechanical properties
- Anesthesia and Neurotoxicity Research
- High-Velocity Impact and Material Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Adrenal and Paraganglionic Tumors
- Immune Response and Inflammation
- Sirtuins and Resveratrol in Medicine
- Breast Lesions and Carcinomas
- Pituitary Gland Disorders and Treatments
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Pediatric Hepatobiliary Diseases and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Biliary and Gastrointestinal Fistulas
- Liver physiology and pathology
Air Force Medical University
2007-2024
Xijing Hospital
2009-2024
Harbin Electric Corporation (China)
2023
China Academy of Chinese Medical Sciences
2023
Thermal Power Research Institute
2018
Wuhan University
2015-2018
Objective: Anesthetic preconditioning appears to be a viable strategy treat ischemic cerebral injury. Here we investigated 1) whether the protection conferred by sevoflurane sustains in time; 2) diminishes mitochondrial dysfunction following ischemia; and 3) permeability transition pore plays crucial role preconditioning. Design: Laboratory investigation. Setting: University research laboratory. Subjects: Sprague-Dawley rats. Interventions: Rats underwent 2 hrs of focal ischemia induced...
Volatile anesthetic isoflurane (ISO) has immunomodulatory effects. The fungal component zymosan (ZY) induces inflammation through toll-like receptor 2 or dectin-1 signaling. We investigated the molecular actions of subanesthetic (0.7%) ISO against ZY-induced inflammatory activation in murine Kupffer cells (KCs), which are known as resident macrophages within liver. observed that reduced cyclooxygenase upregulation and prostaglandin E release, determined by western blot radioimmunoassay,...
Age is the single most important risk factor for cerebral stroke. Unfortunately, effect of age on ischemic brain damage less clear. In this study, we sought to examine potential influence aging histologic and functional outcomes after ischemia. Juvenile (4 weeks age), young adult months mid-aged (11-12 aged (18-19 age) mice were subjected transient middle artery occlusion. There was no remarkable difference infarct volume postoperative days 1 3. However, day 7, exhibited significantly...
We have previously demonstrated the roles of RhoA, Rac1, and Cdc42 in hypoxia-driven angiogenesis. However, role oncogenes hypoxia signaling is poorly understood. Given importance Rho proteins hypoxic response, we hypothesized that family members could act as mediators signal transduction. investigated cross-talk between oncogene-driven transduction pathways explored Rac1 on hypoxia-induced hypoxia-inducible factor (HIF)-1α VEGF expression. Since phosphatidylinositol 3'-kinase (PI3K) pathway...
Anesthetic isoflurane (ISO) has immunomodulatory effects. In the present study, we investigated whether a subanesthetic dose of ISO (0.7%) protected against zymosan (ZY) induced inflammatory responses in murine lung and isolated neutrophils. At 1 6 hrs after ZY administration intraperitoneally, was inhaled for hr, 24 later, inflammation injury were assessed. We found that improved survival rate mice mitigated as characterized by histopathology, wet-to-dry weight ratio, protein leakage,...
Background HER2-positive molecular breast cancer subtypes are characterized by high aggressiveness and malignancy, their metastasis mortality rates among the highest of all types cancer. The use anti-HER2-targeted agents in neoadjuvant therapy has significantly improved prognosis patients with In this study, we investigated efficacy safety a Chinese THP regimen (docetaxel, trastuzumab biosimilar TQB211 plus pertuzumab TQB2440 or pertuzumab) for ER/PR-negative China. Method All enrolled...
Abstract Background Real-world data of Palbociclib are insufficient in China. This study aimed to investigate the treatment pattern and real-world outcomes hormone receptor positive human epidermal growth factor 2 negative (HR+/HER2-) metastatic breast cancer (MBC) patients treated with northwest Methods HR+/HER2- MBC who received 8 centers from July 2017 September 2019 were retrospectively included this study. objective response rate (ORR), progression-free survival (PFS) safety profiles...
Abstract Background Neoadjuvant trastuzumab/pertuzumab (HP) plus chemotherapy for HER2-positive breast cancer (BC) achieved promising efficacy. The additional cardiotoxicity still existed. Brecan study evaluated the efficacy and safety of neoadjuvant pegylated liposomal doxorubicin (PLD)/cyclophosphamide sequential nab-paclitaxel based on HP (PLD/C/HP-nabP/HP). Patients Methods was a single-arm phase II study. Eligible patients with stages IIA-IIIC BC received 4 cycles PLD, cyclophosphamide,...
Luminal subtype breast cancer, accounting for 70 to 80% of all cancers, has been reported be associated with good prognosis. However, the patients large mass or worse position, omental flap transplantation may provide a new option reconstruction.Ten (6 luminal B1, 2 B2, A), were enrolled into study, between January 23, 2015 and August 22, 2016. The mean age was 34.6 ± 6.96 (24-44) years old. Immunohistochemistry demonstrated that tumor cells positive estrogen receptor progestrone...
To explore the correlation between HER-2 status and pathological complete response (pCR) in HER-2-positive breast cancer after dual anti-HER-2 neoadjuvant therapy with trastuzumab pertuzumab. A total of 57 patients admitted to Second Affiliated Hospital Anhui Medical University Xijing Air Force Military University, January 1, 2019 September 30, 2020, were enrolled this multicenter retrospective study. status, including HER-2/CEP17 ratio HER-2/cell number ratio, was detected by FISH. The...