A5057528778- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Abdominal Surgery and Complications
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Appendicitis Diagnosis and Management
- Liver physiology and pathology
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- Click Chemistry and Applications
- Skin and Cellular Biology Research
- Colorectal and Anal Carcinomas
- Intestinal Malrotation and Obstruction Disorders
- Autoimmune Bullous Skin Diseases
- Cancer Research and Treatments
- Colorectal Cancer Screening and Detection
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Barrier Structure and Function Studies
- Machine Learning in Healthcare
- Hip and Femur Fractures
Chengdu Military General Hospital
2015-2025
The First People's Hospital of Shunde
2025
Jinan University
2025
Zhongshan People's Hospital
2025
Guangzhou University of Chinese Medicine
2025
Chengdu University
2019
Kunming General Hospital of Chengdu Military Command
2013-2018
Kyung Hee University
2017-2018
Baylor University
2017
Guangdong Medical College
2015
Objective: The traumatic pancreatitis (TP) has an alarmingly high mortality rate. Our previous research demonstrated that human umbilical cord mesenchymal stem cells-derived exosomes (hucMSC-Exs) could treat TP by inhibiting acinar cell apoptosis. Accordingly, the objective of this study is to unravel intricate mechanism behind repair pancreatic injury in rats. Methods: A gene interaction network miRNA was constructed based on Gene Expression Omnibus (GEO) database (GSE 159814)....
Pancreatoduodenectomy (PD) is a complex surgery with high rate of postoperative complications, for which effective preoperative indicators are currently lacking. Inflammatory indices such as the pan-immune-inflammation value (PIV), platelet-neutrophil product (PPN), and platelet-albumin ratio (PAR) have shown potential biomarkers prognosis in various cancers. However, their predictive complications open-PD (OPD) patients remains underexplored. This study aims to investigate relationship...
Severe acute pancreatitis (SAP) is a fatal disease with natural course of early SAP (ESAP) and late (LSAP) phases. Peripancreatic percutaneous catheter drainage (PCD) effective in management LSAP. Although our previous study indicates that intra-abdominal PCD ahead peripancreatic benefits ESAP patients sterile fluid collections, the mechanism still uncovered.According to therapeutic results, 452 who underwent were divided into group (248 cases), secondary infection (145 primary (59...
To demonstrate the relationship between abdominal paracentesis drainage (APD) and infectious complications in moderately severe acute pancreatitis (MSAP) or (SAP) patients.The effectiveness of APD for SAP was demonstrated our previous study. However, has not been fully elucidated.We conducted a prospective cohort study 255 patients with MSAP SAP. The were divided into 2 groups: who underwent (group 1) did undergo 2). Four types evaluated: bacteremia, infected necrosis, pneumonia, sepsis....
Improved mortality prediction among intensive care unit (ICU) inpatients is a valuable and challenging task. Limited clinical data, especially with appropriate labels, are an important element restricting accurate predictions. Generative adversarial networks (GANs) excellent generative models have shown great potential for data simulation. However, there been no relevant studies using GANs to predict ICU inpatients. In this study, we aim evaluate the predictive performance of variant GAN...
This study aimed to evaluate acute pancreatitis (AP) severity using convolutional neural network (CNN) models with enhanced computed tomography (CT) scans. Three-dimensional DenseNet CNN were developed and trained the CT scans labeled two assessment methods: index (CTSI) Atlanta classification. Each labeling method was used independently for model training validation. Model performance evaluated confusion matrices, areas under receiver operating characteristic curve (AUC-ROC), accuracy,...
Berberine is a traditional drug used to treat gastrointestinal disorders in China and has been demonstrated attenuate intestinal barrier dysfunction certain animal models. However, the effects of berberine on pancreatitis-induced are yet be fully elucidated. This study aimed investigate effect pretreatment attenuation induced by severe acute pancreatitis (SAP). A total 36 rats were randomly divided into Sham, SAP plus groups. Pancreatitis was using retrograde injection 3% Na-taurocholate...
Objective: The objective of this study is to determine whether abdominal paracentesis drainage (APD) could improve the administration enteral nutrition (EN) in acute pancreatitis.Methods: Between January 2015 and April 2016, a total 161 pancreatitis patients were enrolled randomly assigned either APD group or non-APD group. Several indexes associated with EN, including gastroparesis cardinal symptom index (GCSI), incidence gastrointestinal adverse events, clinical outcomes, recorded.Results:...
Abstract Background Acute pancreatitis (AP) has become a significant global health concern, and high body mass index (BMI) been identified as key risk factor exacerbating this condition. Within context, lipid metabolism assumes critical role. The complex relationship between elevated BMI AP, mediated by metabolism, markedly increases the of complications mortality. This study aimed to accurately define correlation incorporating comprehensive analysis interactions individuals with AP. Methods...
Background High altitude de-acclimatization (HADA) is gradually becoming a public health concern as millions of individuals different occupations migrate to high-altitude areas for work due economic growth in plateau areas. HADA affects people who return lower elevations after exposure high altitudes. It causes significant physiological and functional changes that can negatively impact even endanger life. However, uncertainties persist about the detailed mechanisms underlying HADA. Methods...
Hypoxia-inducible factor 1α (HIF-1α) has been well established as a protective for intestinal barrier function in epithelial cells. Recently, study found that increased HIF-1α-induced dysfunction. We proposed lymphocyte-derived interferon-gamma (IFN-γ) might be responsible the dysfunction caused by HIF-1α. HT-29 cell monolayers were grown presence or absence of IFN-γ under hypoxia. Then, transepithelial electrical resistance was measured, and HIF-1α-modulated factors quantified polymerase...
Liver cancer stem cells (LCSCs) are the key factors for metastasis, recurrent, and drug resistance. LCSCs originated from either hepatocytes dedifferentiation or differentiation arresting of liver normal (LNSCs). Differentiation-inducing therapy is a novel strategy in solid tumors. Furthermore, Notch signaling pathway has been proved to play important role process differentiation. In previous study, malignant transformation cellular model LNSCs built up, this study we trying illustrate...
Accurately predicting length of stay (LOS) is considered a challenging task for health care systems globally. In previous studies on LOS range prediction, researchers commonly pre-classified the ranges, which were same all patients in classification, and then utilized classifier prediction. this study, we innovatively aimed to predict specific each patient (the was different patient).In modified deep neural network (DNN), overall sample error (root mean square (RMSE) method), estimated...
Laparoscopic total mesorectal excision (TME) for rectal cancer has become a widely used surgical strategy in the treatment of cancer. surgery aims to provide patients with curative resection as well minimize postoperative morbidity. This study was designed analyze foreseeable risk factors linked morbidity undergoing laparoscopic excision.From February 2008 May 2010, 306 consecutive underwent TME. Postoperative complications including wound infection, pneumonia, urethritis were recorded....
Abstract Background There are few reports about the effect of glucocorticoids in treatment acute pancreatitis humans. This study aims to evaluate by propensity score matching analysis. Results Acute patients admitted between 2014 and 2019 were collected from database analyzed. Included divided into glucocorticoids-used group (GC group) non-glucocorticoids-used (NGC according whether used. A total 818 eligible included final Seventy-six treated with glucocorticoids, 742 without...
Our previous reports demonstrated that abdominal paracentesis drainage (APD) exerts a beneficial effect on severe acute pancreatitis (SAP) patients. However, the underlying mechanisms for this effectiveness are not well understood.A retrospective cohort of 132 consecutive non-hypertriglyceridemia (HTG)-induced SAP patients with triglyceride (TG) elevation and pancreatitis-associated ascitic fluid (PAAF) was recruited from May 2010 to 2015 included in study. The were divided into two groups:...