A5100397410- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Fluoride Effects and Removal
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- Bone and Dental Protein Studies
- Hippo pathway signaling and YAP/TAZ
- Erythrocyte Function and Pathophysiology
- Hemoglobin structure and function
- Sperm and Testicular Function
- Esophageal Cancer Research and Treatment
- Phytochemicals and Antioxidant Activities
- Groundwater and Isotope Geochemistry
- Wastewater Treatment and Nitrogen Removal
- Heme Oxygenase-1 and Carbon Monoxide
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Adipose Tissue and Metabolism
Southwest Forestry University
2025
Chinese Academy of Sciences
2009-2025
Dalian Medical University
2025
Chongqing Medical University
2020-2025
Second Affiliated Hospital of Chongqing Medical University
2025
Zhengzhou University
2015-2025
Research Center for Eco-Environmental Sciences
2024-2025
Henan Institute of Technology
2025
Peking University People's Hospital
2024
First Affiliated Hospital of Zhengzhou University
2015-2024
We have fabricated the glucose-sensitive protein hollow microcapsules from hemoglobin (Hb) and glucose oxidase (GOx) via layer-by-layer technique with glutaraldehyde (GA) as a cross-linking agent. demonstrated coupled enzymatic reactions between Hb GOx within capsules by means of CLSM. The real-time monitoring consumption may be useful for design sensor. Furthermore, to further study effect on capsules, we investigated wall permeability (Hb/GOx)(5) capsules. It was found that could enhance...
Hepatocyte growth factor (HGF) is a heparin-binding cytokine that enhances growth, motility, and angiogenesis of many tumor types, including multiple myeloma where it often highly expressed. However, little known regarding what controls HGF level activity in these tumors. Evaluation bone marrow biopsies from patients revealed strong positive correlation between the levels heparanase, an endoglucuronidase to promote aggressive behavior. In vitro, addition recombinant heparanase cells or...
Abstract Ginsenoside Rg1 has been demonstrated to have cardiovascular protective effects. However, whether the cardioprotective effects of ginsenoside are mediated by endoplasmic reticulum ( ER ) stress‐induced apoptosis remain unclear. In this study, among 80 male Wistar rats, 15 rats were randomly selected as controls; remaining 65 received a diet rich in fat and sugar content for 4 weeks, followed intraperitoneal injection streptozotocin STZ , 40 mg/kg) establish diabetes model. Seven...
In the clinic selective serotonin reuptake inhibitors (SSRIs), like Fluoxetine, remain primary treatment for major depression. It has been suggested that miR-16 regulates transporters (SERT) via raphe nuclei and hippocampal responses to antidepressants. However, underlying mechanism regulatory pathways are still obtuse. Here, a chronic unpredicted mild stress (CUMS) depression model in rats was established, then intragastric Fluoxetine injections were administered duration of three weeks. An...
Microbial flocculants (MBFs), a class of eco-friendly and biodegradable biopolymers produced by various microorganisms, have gained increasing attention as promising alternatives to conventional chemical in wastewater treatment pollutant removal. This review presents comprehensive overview the current state MBF research, encompassing their diverse sources (bacteria, fungi, algae), major categories (polysaccharides, proteins, glycoproteins), production processes, flocculation performance...
// Yang 1 , Ni Hou Xiaofei Wang Lumin Su'e Chang Kang He Zhenghao Zhao Xiaoge Tusheng Song Chen Huang 1, 2, 3 Department of Genetics and Molecular Biology, Xi'an Jiaotong University College Medicine, Xi'an, Shaanxi, China 2 Key Laboratory Environmentally Genetically Associated Diseases at University, Ministry Education, Cardiovascular Research Center, Correspondence to: Huang, e-mail: hchen@mail.xjtu.edu.cn Song, tu.sheng@mail.xjtu.edu.cn Keywords: miR-15b-5p, hepatocellular carcinoma,...
MicroRNAs have been broadly implicated in cancer, but their exact function and mechanism carcinogenesis remain poorly understood. Aberrant miR-486-5p expression is frequently found human cancers. Here we showed a significant overexpression of prostate cancer compared with that normal tissue cells, proposed altered the contributed to cancer. Firstly, inhibition reduced cancercell proliferation, migration, colonization vitro tumor development vivo. Moreover, integrated RNA sequencing target...
Recent studies observed that altered energy metabolism has become widespread in cancer cells along with other cancer-associated traits have been accepted as hallmarks of cancer. Akt signaling pathway is involved the aerobic glycolysis program. However, mechanisms underlying regulation and activity gliomas remain unclear. MicroRNAs are a group small non-coding RNAs can function endogenous RNA interference to regulate expression targeted genes. This study was conducted detect miR-7 targeting...
Background: In advanced atherosclerosis, chronic endoplasmic reticulum (ER) stress induces foam cells apoptosis and generates inflammatory reactions. Methods: THP-1 macrophage-derived (FC) were incubated with 1 mM 5-aminolevulinic acid (ALA). After ALA mediated sonodynamic therapy (ALA-SDT), of FC was assayed by Annexin V-PI staining. Intracellular reactive oxygen species (ROS) mitochondrial membrane potential detected staining CellROX® Green Reagent jc-1. Pretreatment N-acetylcysteine...
AIMTo investigate the potential role of microRNA-30a (miR-30a) in esophageal squamous cell carcinoma (ESCC).
Hepatic myofibroblasts, activated hepatic stellate cells (HSCs), are the main cell type of extracellular matrix (ECM) deposition during fibrosis. Aberrant DNA methylation-regulated HSCs activation in liver fibrogenesis has been reported, but functional roles and mechanisms methylation fibrosis remain to be elucidated. In present study, reduced representation bisulfite sequencing (RRBS) analysis primary revealed hypermethylation patterns Interestingly, we found SAD1/UNC84 domain protein-2...
DEK protein is critical to the formation of neutrophil extracellular traps (NETs) in rheumatoid arthritis (RA). Blocking using aptamer DTA via articular injection has been shown have robust anti-inflammatory efficacy a previous study. However, prone nuclease degradation and renal clearance vivo. RA systemic disease that involves multiple joints, local impractical clinical settings. In this study, was modified with methoxy groups on all deoxyribose sugar units inverted deoxythymidine 3′ end...
Tannin-furanic foams with excellent properties have attracted increasing interest due to their advantages such as easy preparation, light weight, and thermal insulation. However, unsatisfactory mechanical strength has limited the expansion of applications. Herein, three different metal ions (Cu2+, Fe3+, Zn2+) were chosen enhance tannin-furanic foam prepared by stirring provoked a foaming approach. The positive effects originating from complexation are attributed associated connection between...
To extract intratumoral, peritumoral, and integrated intratumoral-peritumoral CT radiomic features, develop multi-source models using various machine learning algorithms to identify the optimal model, integrate clinical factors establish a nomogram for predicting therapeutic response induction therapy(IT) in locally advanced non-small cell lung cancer. This study included 209 patients with cancer (LA-NSCLC) who received IT as training cohort, an external validation cohort comprising 50 from...