A5011761868- Advanced Mathematical Modeling in Engineering
- Stability and Controllability of Differential Equations
- Wastewater Treatment and Nitrogen Removal
- Higher Education and Teaching Methods
- Pharmacological Effects of Natural Compounds
- Nonlinear Photonic Systems
- Advanced Mathematical Physics Problems
- Constructed Wetlands for Wastewater Treatment
- Nonlinear Waves and Solitons
- Rheumatoid Arthritis Research and Therapies
- Educational Technology and Assessment
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Reading and Literacy Development
- Membrane Separation Technologies
- Numerical methods in inverse problems
- Software Reliability and Analysis Research
- Pregnancy and preeclampsia studies
- Water Treatment and Disinfection
- Microbial Community Ecology and Physiology
- Zeolite Catalysis and Synthesis
- Membrane-based Ion Separation Techniques
- Education and Work Dynamics
- Nonlinear Differential Equations Analysis
- Infrastructure Maintenance and Monitoring
Research Center for Eco-Environmental Sciences
2021-2025
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2025
Zhengzhou University
2023-2024
Nanjing University of Information Science and Technology
2016-2023
University of Science and Technology of China
2022-2023
Annoroad Gene Technology (China)
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2022
Kangda College of Nanjing Medical University
2022
Nanjing Medical University
2022
Abstract Wu-tou decoction (WTD) has been extensively used for the treatment of rheumatoid arthritis (RA). Due to lack appropriate methods, pharmacological mechanisms WTD acting on RA have not fully elucidated. In this study, a list putative targets compositive compounds containing in were predicted by drugCIPHER-CS. Then, interaction network and known RA-related was constructed hub nodes identified. After constructing hubs, four topological features each hub, including degree, node...
Immune checkpoint inhibitors (ICIs) have become important treatment strategies, yet responses vary among patients and predictive biomarkers are urgently needed. Mutations in KMT2C KMT2D lead to increased levels of genomic instability. Therefore, we aimed examine whether KMT2C/D mutations might be a predictor immunotherapeutic efficacy. Here, investigated the associations loss-of-function (LOF) variants with tumor mutation burden (TMB), MSI-H, PD-L1 expression, tumor-infiltrating leukocytes...
AimTo screen novel markers for hepatocellular carcinoma (HCC) by a combination of expression profile, interaction network analysis and clinical validation. MethodsHCC significant molecules which are differentially expressed or had genetic variations in HCC tissues were obtained from five existing related databases (OncoDB.HCC, HCC.net, dbHCCvar, EHCO Liverome). Then, the protein-protein (PPI) these was constructed. Three topological features ('Degree', 'Betweenness', 'Closeness') k-core...
In this paper, we construct the general Darboux transformation on Sasa–Satsuma equation and represent iterated solutions in terms of three-component Wronskian. From once-iterated solution, derive breather as well single- double-hump solitons. We also analyze three types collisions: soliton–soliton, breather–breather soliton–breather collisions. The surprising result is that collision may exhibit shape-changing phenomena, is, one (or soliton) change into a soliton breather) when interacting...
Several complex molecular events are involved in tumorigenesis of hepatocellular carcinoma (HCC). The interactions these molecules may constitute the HCC imbalanced network. Gansui Banxia Tang (GSBXT), as a classic Chinese herbal formula, is popular complementary and alternative medicine modality for treating HCC. In order to investigate therapeutic effects pharmacological mechanisms GSBXT on reversing network, we current study developed comprehensive systems approach integrating...
In the mouse, decidual cells differentiate from uterine stromal in response to steroid hormones and signals arising embryo. Decidual are crucially involved creating intrauterine environment conducive embryonic development. Among their many functions is production of cytokines related prolactin (PRL), including prolactin-related protein (DPRP). DPRP a heparin-binding cytokine, which abundantly expressed decidua. this investigation, we have isolated mouse Dprp gene, characterized its structure...
In this paper, we consider a viscoelastic Kirchhoff equation with Balakrishnan-Taylor damping, dynamic boundary conditions and time-varying delay term acting on the boundary. By using Faedo-Galerkin approximation method, first prove well-posedness of solutions. introducing suitable energy perturbed Lyapunov functionals, then general decay results, from which usual exponential polynomial rates are only special cases. To achieve these following two cases according to coefficient α strong...
Aim . To investigate pharmacological mechanisms of Wu Tou Tang acting on rheumatoid arthritis (RA) by integrating network analysis at a system level. Methods and Results Drug similarity search tool in Therapeutic Targets Database was used to screen 153 drugs with similar structures compositive compounds each ingredient identify 56 known targets these as predicted molecules which affects. The recall, precision, accuracy, F1-score, were calculated evaluate the performance this method, were,...
This study investigated factors that would affect a reader's understanding of the main idea at global level and explicit implicit ideas local level. Fifty-seven first-year university students taking college reading course took comprehension test on an expository text. Statistical analyses revealed text structure had moderate effect idea; only weak correlation existed between ideas, particularly idea. Analysis idea's textual features suggested identification was affected by degree...
Wu-tou decoction (WTD) is a classic traditional Chinese medicine formula and has been used effectively to treat joint diseases clinically. Previous reports indicated that WTD possesses anti-inflammatory activity; however, its actions on pain have not clarified. Here, we investigated the antinociceptive activity of in CFA-induced mice, possible mechanism action associated with transient receptor potential (TRP) ion channels was also explored. Our results showed 1.58, 3.15, 6.30 g/kg...
In this article, we study the initial boundary value problem in one space variable for an elastic–thermoelastic bar with elastic part being surrounded by two thermoelastic parts presence of infinite memory term, which heat conduction thermoelasticity is described Cattaneo's law, removing physical paradox propagation speed signals. The main difficulties handing are that system does not have any frictional damping and dissipative effects induced law usually weaker than those Fourier's law. To...
We present results on the dynamics of split-ring dimers having both gain and loss in one-dimensional nonlinear parity-time- ($\mathcal{PT}$-)symmetric magnetic metamaterials. For long-wave (continuum) limit approximation weakly limit, we show analytic existence gap soliton solutions symmetry-breaking phenomenon at a critical value or term.