A5066638147- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant biochemistry and biosynthesis
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Systemic Sclerosis and Related Diseases
- Colorectal Cancer Treatments and Studies
- Coastal wetland ecosystem dynamics
- Plant nutrient uptake and metabolism
- Cancer-related Molecular Pathways
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Gene Expression Analysis
- Plant responses to water stress
- Lung Cancer Research Studies
- Chromatography in Natural Products
- Neuroendocrine regulation and behavior
- Genomics and Rare Diseases
- Coconut Research and Applications
- Kruppel-like factors research
- Esophageal Cancer Research and Treatment
- Galectins and Cancer Biology
Hainan Provincial Academy of Agricultural Sciences
2022-2025
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Annoroad Gene Technology (China)
2021-2023
Xiangya Hospital Central South University
2013-2022
Central South University
2013-2022
Technologies pour la Santé
2021
The University of Texas Southwestern Medical Center
2015
Cancer Research And Biostatistics
2013
Beijing Computing Center
2012
Studies in adolescents and adults have demonstrated that polymorphisms putative psychiatric risk genes are associated with differences brain structure, but cannot address when development these relationships arise. To determine if common genetic variants disrupted-in-schizophrenia-1 (DISC1; rs821616 rs6675281), catechol-O-methyltransferase (COMT; rs4680), neuregulin 1 (NRG1; rs35753505 rs6994992), apolipoprotein E (APOE; ɛ3ɛ4 vs. ɛ3ɛ3), estrogen receptor alpha (ESR1; rs9340799 rs2234693),...
There are numerous reports of sexual dimorphism in brain structure children and adults, but data on sex differences infancy extremely limited. Our primary goal was to identify neonatal structure. secondary explore whether related androgen exposure or sensitivity. Two hundred ninety-three neonates (149 males) received high-resolution structural magnetic resonance imaging scans. Sensitivity measured using the number cytosine, adenine, guanine (CAG) triplets receptor gene ratio second fourth...
Immune checkpoint inhibitors (ICIs) have become important treatment strategies, yet responses vary among patients and predictive biomarkers are urgently needed. Mutations in KMT2C KMT2D lead to increased levels of genomic instability. Therefore, we aimed examine whether KMT2C/D mutations might be a predictor immunotherapeutic efficacy. Here, investigated the associations loss-of-function (LOF) variants with tumor mutation burden (TMB), MSI-H, PD-L1 expression, tumor-infiltrating leukocytes...
Sweet potato is an important food, feed and industrial raw material, its tubers are rich in starch, carotenoids anthocyanins. To elucidate the gene expression regulation metabolic characteristics during development of sweet tubers, transcriptomic metabolomic analyses were performed on three different varieties at developmental stages (70, 100, 130 days (d)). RNA-seq analysis revealed that 16,303 differentially expressed genes (DEGs) divided into 12 clusters according to their patterns,...
Differentiated plant cells can retain the capacity to be reprogrammed into pluripotent stem during regeneration. This is associated with both cell cycle reactivation and acquisition of specific cellular characters. However, molecular mechanisms underlying reprogramming protoplasts remain largely unknown. Protoplasts moss Physcomitrella patens easily regenerate protonema therefore provide an ideal system explore how differentiated produce cells.We obtained genome-wide digital gene expression...
Abstract Chlorogenic acids (CGAs) are important secondary metabolites produced in sweet potato. However, the mechanisms of their biosynthesis and regulation remain unclear. To identify potential genes involved CGA biosynthesis, analysis dynamic changes components RNA sequencing were performed on young leaves (YL), mature (ML), stems (YS), (MS) storage roots (SR). Accordingly, we found that accumulation six varied among different tissues developmental stages, with YS YL recording highest...
Leptomeningeal metastasis (LM) commonly occurs in non-small cell lung cancer (NSCLC) patients and has a poor prognosis. Due to limited access leptomeningeal lesions, the genetic characteristics of LM have not been explored date. Cerebrospinal fluid (CSF) may be most representative liquid biopsy medium obtain genomic information from NSCLC.CSF biopsies matched peripheral blood were collected 33 NSCLC with LM. We profiled alterations by comparing CSF cell-free DNA (cfDNA) plasma cfDNA. Somatic...
Microsatellite instability (MSI) is an important biomarker for predicting the response to immunotherapy and prognosis that mainly results from a defective DNA mismatch repair (MMR) system strongly correlates with high tumor mutation burden (TMB). Herein, we developed novel method integrates MSI score, MMR status TMB level identify next-generation sequencing (NGS) data. The displays sensitivity of 96.80%, specificity 99.96% overall accuracy 99.89%, compared current standards. Using our...
Combination immunotherapy can overcome the limited objective response rates of PD-1 blockade. Interferon alpha (IFN-α) has been proven to be effective in modulating immune responses and may enhance clinical According practice guidelines, IFN-α was recommended as adjuvant therapy for stage IIB/C melanoma patients. However, impact prior on efficacy subsequent blockade not previously reported. Therefore, we performed a retrospective analysis patients addressed whether enhanced pembrolizumab...
Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare subtype of non-small-cell lung cancer. This study aims to compare the efficacy and safety perioperative PD-1/PD-L1 inhibitor plus chemotherapy versus alone in stage II-IIIB PLELC patients. retrospective included Patients received either immuno-chemotherapy (IO-Chemo) or (Chemo). Data on patient characteristics, treatments, efficacy, toxicities, pathology were collected. endpoints major pathological response (MPR) event-free...
The aim of this study was to identify biomarkers dermatomyositis (DM). analysis conducted by retrieving DM-related cDNA microarray data sets from public databases. Gene ontology, Kyoto encyclopedia genes and genomes, protein–protein interaction analyses were performed, together with quantitative PCR-based detection in muscle tissue after stimulation serum patients DM or healthy controls. Our five identified 20 common differentially expressed that are closely associated DM. PCR showed mRNAs...
Abstract Background Isocitrate dehydrogenase (IDH) is an appealing target for anticancer therapy, and IDH (IDH1/2) inhibitors have been approved targeted therapy of acute myeloid leukemia (AML) Cholangiocarcinoma. The therapeutic potential non‐small‐cell lung cancer (NSCLC) patients under active clinical investigation. Thus, it would be necessary meaningful to study the molecular characteristics mutation in NSCLC patients, especially Chinese population. Methods A total 17,978 with who...
Although the functions of basic leucine zipper (bZIP) family transcription factors in regulation various abiotic stresses are beginning to be unveiled, precise roles bZIP proteins plants coping with submergence stress remain unclear. Here we identified a gene GmbZIP71-4 from soybean, which localized nucleus. The over-expressed tabocco line showed reduced resistance due decreased abscisic acid (ABA) content. GO and KEGG pathway analysis based on chromatin immunoprecipitation assay sequencing...
Green soybean (
Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and characterized by immune inflammation. The pathogenesis of SLE complex involves genetic environmental components. Methods In this study, single nucleotide polymorphisms (SNPs) closely related to were searched through integration analysis public gene expression profiles from Gene Expression Omnibus European Bioinformatics Institute data, immunochip data in a genome-wide association study....
Brain metastasis mainly originates from lung cancer. Napsin A and TTF-1 factors have frequently been detected in adenocarcinoma cases. tumors with napsin positive are easily classified as origin. However, some thyroid cancers also exhibit these clinical features. Besides, is the most common of undifferential Therefore, it requires development novel diagnostic tools to aid distinguishing between pulmonary origin.We reported a case that was initially diagnosed brain metastatic cancer based on...