A5101647773- Aquaculture disease management and microbiota
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Animal Genetics and Reproduction
- Animal Virus Infections Studies
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Invertebrate Immune Response Mechanisms
- Rabbits: Nutrition, Reproduction, Health
- Lipid Membrane Structure and Behavior
- Marine and coastal plant biology
- Lung Cancer Treatments and Mutations
- Algal biology and biofuel production
- Coral and Marine Ecosystems Studies
- Reproductive Biology and Fertility
- Bacterial Genetics and Biotechnology
- Sexual Differentiation and Disorders
- Cytomegalovirus and herpesvirus research
- Aquaculture Nutrition and Growth
- Caveolin-1 and cellular processes
- Nanoparticle-Based Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Genetically Modified Organisms Research
Qingdao Agricultural University
2024
Chinese Academy of Sciences
2021-2023
Hohai University
2019-2023
Institute of Hydrobiology
2021-2023
Wuhan University of Technology
2022
China Medical University
2022
Liaoning Cancer Hospital & Institute
2022
Ocean University of China
2019-2020
Institute of Animal Sciences
2015
Chinese Academy of Agricultural Sciences
2015
Abstract The P450 side‐chain cleavage enzymes P450scc (Cyp11a) and 11β‐hydroxylase (Cyp11b) play important roles in sex steroid cortisol production. Here, two duplicates of cyp11 genes were identified Japanese flounder ( Paralichthys olivaceus ): Pocyp11a Pocyp11b , respectively. Phylogenetic analysis amino acid sequence alignment revealed that shared significant identity with sequences other teleost fish species. quantitative real‐time polymerase chain reaction (qRT‐PCR) results indicated...
A cyanophage PaV-LD, previously isolated from harmful filamentous cyanobacterium Planktothrix agardhii, was sequenced, and co-expression of its two ORFs in tandem, ORF123 ORF124, inhibited growth on the model Synechocystis sp. PCC6803 cells. However, mechanism action ORF124 alone remains to be elucidated. In this study, we aimed study individual function or PaV-LD. Our data showed that encoded an endopeptidase, which harbored M23 family peptidase domain a transmembrane region. The expression...
The genomic traits of cyanophages and their potential for metabolic reprogramming the host cell remain unknown due to limited number studies on cyanophage isolates. In present study, a lytic Microcystis cyanophage, MaMV-DH01, was isolated identified. MaMV-DH01 has an icosahedral head approximately 100 nm in diameter tail 260 length. Its burst size is large, with 145 phage particles/infected cell; it latent period 2 days, shows high stability under pH temperature stresses. Multiple infection...
The channel catfish virus (CCV, Ictalurid herpesvirus 1) has caused sustained economic losses in the fish industry because of its strong infectivity and pathogenicity. Thus, it is necessary to determine function viral proteins CCV infection process. present study aimed characterize glycoprotein ORF59 explore impact on host cells. Firstly, exclusive presence membrane fraction cell lysate subcellular localization verified that a protein expressed at late-stage infection. A blocking assay using...
Abstract The expression of herpesvirus genes during infection tissue culture cells can be classified into three main classes: immediate‐early (IE), early and late. transcriptional regulation IE is a critical regulatory step in the initiation viral infection, with their differing from that late genes. Herein, we report an gene (ORF3) promoter channel catfish virus (CCV, Ictalurid 1) activated regardless presence or absence CCV indicating ORF3 efficiently driven by host–cell transcription...
The channel catfish virus (CCV) is a lethal pathogen to aquatic animals that can provoke severe haemorrhagic disease in juvenile catfish. Although the CCV genome has been fully sequenced, molecular mechanisms of infection and pathogenesis are less well known. Genomic DNA replication necessary key event for life cycle. In this study, impacts putative helicase primase encoded by viral ORF25 ORF63 on were evaluated ovary (CCO) cells. results showed number copies was decreased significantly...
Abstract Background Isocitrate dehydrogenase (IDH) is an appealing target for anticancer therapy, and IDH (IDH1/2) inhibitors have been approved targeted therapy of acute myeloid leukemia (AML) Cholangiocarcinoma. The therapeutic potential non‐small‐cell lung cancer (NSCLC) patients under active clinical investigation. Thus, it would be necessary meaningful to study the molecular characteristics mutation in NSCLC patients, especially Chinese population. Methods A total 17,978 with who...
The utility of the mitochondrial genomes (mitogenomes) in analyzing evolutionary history animals has been proven. Five deep-sea corals (
Channel catfish virus (CCV; family Alloherpesviridae) infects channel catfish, causing great harm to aquaculture fisheries and economic development. Attachment is the first step in viral infection relies on interaction of virions with components extracellular matrix (ECM). The present study aimed explored role main three ECM CCV attachment. Western blotting quantitative real-time PCR analysis showed that neither collagen nor hyaluronic acid treatments had significant effects When exogenous...