A5091660102- Laser Material Processing Techniques
- Laser-induced spectroscopy and plasma
- High-pressure geophysics and materials
- Photonic and Optical Devices
- Ion-surface interactions and analysis
- Force Microscopy Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Thyroid Cancer Diagnosis and Treatment
- Laser-Plasma Interactions and Diagnostics
- Diamond and Carbon-based Materials Research
- Advanced Materials Characterization Techniques
- Advanced Fiber Laser Technologies
- Terahertz technology and applications
- Laser-Matter Interactions and Applications
- Quantum, superfluid, helium dynamics
- Analytical chemistry methods development
- Advanced Chemical Physics Studies
- nanoparticles nucleation surface interactions
- Atomic and Molecular Physics
- Surface and Thin Film Phenomena
- Photonic Crystals and Applications
- Electron and X-Ray Spectroscopy Techniques
- Pancreatic and Hepatic Oncology Research
- Nanoporous metals and alloys
- Advanced X-ray Imaging Techniques
Guangdong Provincial People's Hospital
2020-2025
Southern Medical University
2014-2025
SLAC National Accelerator Laboratory
2016-2024
Chengdu University
2024
Fujian Medical University
2013-2024
Menlo School
2016-2024
Union Hospital
2021-2024
Guangdong Academy of Medical Sciences
2020-2023
Peking University
2023
University of Alberta
2010-2022
The ultrafast laser excitation of matters leads to nonequilibrium states with complex solid-liquid phase-transition dynamics. We used electron diffraction at mega-electron volt energies visualize the melting gold on atomic scale length. For energy densities approaching irreversible regime, we first observed heterogeneous time scales 100 1000 picoseconds, transitioning homogeneous that occurs catastrophically within 10 20 picoseconds higher densities. showed evidence for coexistence solid and...
The matter in extreme conditions end station at the Linac Coherent Light Source (LCLS) is a new tool enabling accurate pump–probe measurements for studying physical properties of high-energy density (HED) physics regime. This instrument combines world's brightest x-ray source, LCLS beam, with high-power lasers consisting two nanosecond Nd:glass laser beams and one short-pulse Ti:sapphire laser. These produce short-lived states high pressures, temperatures or densities that are important...
The physics and chemistry of liquid solutions play a central role in science, our understanding life on Earth. Unfortunately, key tools for interrogating aqueous systems, such as infrared soft X-ray spectroscopy, cannot readily be applied because strong absorption water. Here we use gas-dynamic forces to generate free-flowing, sub-micron, sheets which are two orders magnitude thinner than anything previously reported. Optical, infrared, spectroscopies used characterize the sheets, found...
Therapeutic outcome for the treatment of glioma was often limited due to drug resistance and low permeability across multiple physiological barriers, including blood-brain barrier (BBB), blood-tumor (BTB). In order overcome these hurdles, we designed T7 DA7R dual peptides-modified liposomes (abbreviated as T7/DA7R-LS) efficiently co-delivery doxorubicin (DOX) vincristine (VCR) in this study. is a seven-peptide ligand transferrin receptors (TfR) capable circumventing BBB then targeting...
Studies of laser-heated materials on femtosecond timescales have shown that the interatomic potential can be perturbed at sufficiently high laser intensities. For gold, it has been postulated to undergo a strong stiffening leading an increase phonon energies, known as hardening. Despite efforts investigate this behavior, only measurements low absorbed energy density performed, for which interpretation experimental data remains ambiguous. By using in situ single-shot x-ray diffraction hard...
Using a chirped pulse probe technique, we have obtained single-shot measurements of temporal evolution ac conductivity at 1.55 eV (800 nm) during electron energy relaxation in nonequilibrium warm dense gold with densities up to $4.1\text{ }\text{ }\mathrm{MJ}/\mathrm{kg}$ ($8\ifmmode\times\else\texttimes\fi{}{10}^{10}\text{ }\mathrm{J}/{\mathrm{m}}^{3}$). The results uncover important changes that been masked an earlier experiment. Equally significant, they provide valuable tests ab initio...
We present a model to describe thermophysical and optical properties of two-temperature systems consisted heated electrons cold ions in solid lattice that occur during ultrafast heating experiments. Our is based on ab initio simulations within the framework density functional theory. The are obtained by evaluating Kubo-Greenwood formula. By applying material parameters our we able temperature relaxation process femtosecond-laser-heated gold its same theoretical framework. Recent...
Abstract Magnetostriction, the strain induced by a change in magnetization, is universal effect magnetic materials. Owing to difficulty unraveling its microscopic origin, it has been largely treated phenomenologically. Here, we show how source of magnetostriction—the underlying magnetoelastic stress—can be separated time domain, opening door for an atomistic understanding. X-ray and electron diffraction are used separate sub-picosecond spin lattice responses FePt nanoparticles. Following...
Abstract Objectives To investigate the ability of currently used ultrasound-based malignancy risk stratification systems for thyroid neoplasms (ATA, AACE/ACE/AME, K-TIRADS, EU-TIRADS, ACR-TIRADS and C-TIRADS) in distinguishing follicular carcinoma (FTC) from adenoma (FTA). Additionally, we evaluated these correctly determining indication biopsy. Methods Three hundred twenty-nine with definitive postoperative histopathology were included. The nodules categorized according to each six systems,...
We describe measurements of the DC electrical conductivity warm dense matter using ultrafast terahertz (THz) pulses. THz fields are sufficiently slowly varying that they behave like on timescale electron–electron and electron–ion interactions hence probe DC-like responses. Using a novel single-shot electro-optic sampling technique, laser-generated was determined with <1 ps temporal resolution. present details detection methodology as well considerations for experiments. We, then,...
Vertically stacked transition metal dichalcogenide-graphene heterostructures provide a platform for novel optoelectronic applications with high photoresponse speeds. Photoinduced nonequilibrium carrier and lattice dynamics in such underlie these but have not been understood. In particular, the dependence of photoresponses on twist angle, key tuning parameter, remains elusive. Here, using ultrafast electron diffraction, we report simultaneous visualization charge transfer electron–phonon...
Abstract Key insights in materials at extreme temperatures and pressures can be gained by accurate measurements that determine the electrical conductivity. Free-electron laser pulses ionize excite matter out of equilibrium on femtosecond time scales, modifying electronic ionic structures enhancing scattering properties. The transient evolution conductivity manifests energy coupling from high temperature electrons to low ions. Here we combine accelerator-based, high-brightness multi-cycle...
Liquid sheet jet formation holds immense promise to provide a continuously replenished target for static structural biology and high energy density studies conducted in X-ray free electron laser, synchrotron, pulsed facilities.
Objective: Current Thyroid Imaging Reporting and Data Systems (TIRADSs) exhibit considerable variability in size thresholds for fine-needle aspiration biopsy (FNAB). This study harnesses the systematic variations among dissimilar TIRADSs optimization strategies selection. Methods: The analysis focused on discrepancies observed four widely utilized TIRADS systems: ACR-TIRADS, Kwak-TIRADS, C-TIRADS, EU-TIRADS. Subsequently, several methods derived from combination of two were constructed via...
The results of laser-driven proton beam focusing and heating with a high energy (170J) short pulse are reported. Thin hemispherical aluminum shells illuminated the Gekko petawatt laser using 1μm light at intensities ∼3×1018W∕cm2 measured thin Al slabs. pattern is inferred by imaging visible extreme-ultraviolet Planckian emission from rear surface. When slabs 100μm thick were placed distances spanning focus waist, highest temperatures produced 0.94× hemisphere radius beyond equatorial plane....
Toxic heavy metals in water pose a potential health and environmental risk to people. The current techniques used for trace analysis are either time-consuming or of low sensitivity. It is necessary develop fast sensitive technique monitor analyze toxic water. In this work, the were electrically deposited on surface polished high purity aluminium plate then quantitatively analyzed by laser-induced breakdown spectroscopy (LIBS). was demonstrated that electrical-deposition method significantly...
Materials exposed to extreme radiation environments such as fusion reactors or deep spaces accumulate substantial defect populations that alter their properties and subsequently the melting behavior. The quantitative characterization requires visualization with femtosecond temporal resolution on atomic-scale length through measurements of pair correlation function. Here, we demonstrate experimentally electron diffraction at relativistic energies opens a new approach for studies kinetics. Our...
Angularly resolved X-ray scattering measurements from fs-laser heated hydrogen have been used to determine the equilibration of electron and ion temperatures in warm dense matter regime. The relaxation rapidly cryogenic is visualized using 5.5 keV pulses Linac Coherent Light (LCLS) source a 1 Hz repetition rate pump-probe setting. We demonstrate that electron-ion energy transfer faster than quasi-classical Landau-Spitzer models use ad hoc cutoffs Coulomb logarithm.
Introduction: Resistance to gemcitabine is common and critically limits its therapeutic efficacy in pancreatic ductal adenocarcinoma (PDAC). Methods: We constructed 17 patient-derived xenograft (PDX) models from PDAC patient samples identified the most notable responder by screening PDX sets vivo. To analyze tumor evolution microenvironmental changes pre- post-chemotherapy, single-cell RNA sequencing (scRNA-seq) was performed. Results: ScRNA-seq revealed that promoted expansion of subclones...
Abstract The Freundlich equation ( x/m = K f C 1/n e ) has been used widely in sorption studies chemistry and environmental research. Two problems arise comparing sorbate‐sorbent systems if ≠ 1 or values differ. First, it is often not possible to compare from the literature they were derived different units of . Second, exponent 1/n, determines interpretation Consequently, oc—f problematic. We propose a way characterize dynamics that follow isotherm avoids caused by values. show that: (i)...
Water contaminated with toxic heavy metals can be a great risk to humans. Laser-induced breakdown spectroscopy (LIBS) is promising candidate monitor in aqueous solutions on site, but the sensitivity still major problem. To perform sensitive analysis of analyte LIBS, thin wood sample substrate was used as liquid absorber transform solid analysis. We focus investigating performance this technique using different laser wavelengths (266, 532, and 1064 nm) low pulse energy (<5 mJ) number shots...