A5034561361- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Radiation Dose and Imaging
- Atomic and Subatomic Physics Research
- Radiation Effects in Electronics
- Breast Cancer Treatment Studies
- Nonmelanoma Skin Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Luminescence Properties of Advanced Materials
- Cutaneous lymphoproliferative disorders research
- Nuclear Physics and Applications
- Advanced Optical Sensing Technologies
- Advances in Oncology and Radiotherapy
- Analytical Chemistry and Sensors
- Effects of Radiation Exposure
- bioluminescence and chemiluminescence research
- Advanced Fluorescence Microscopy Techniques
- Advanced MRI Techniques and Applications
- Advanced X-ray Imaging Techniques
Dartmouth College
2016-2025
Dartmouth Hospital
2021-2024
Dartmouth Cancer Center
2022-2024
University of Wisconsin–Madison
2023
DoseOptics (United States)
2019-2022
Dartmouth–Hitchcock Medical Center
2020
Czech Academy of Sciences, Institute of Physics
2016-2019
Extreme Light Infrastructure Beamlines
2019
SLAC National Accelerator Laboratory
2019
Chalmers University of Technology
2018
The physics and chemistry of liquid solutions play a central role in science, our understanding life on Earth. Unfortunately, key tools for interrogating aqueous systems, such as infrared soft X-ray spectroscopy, cannot readily be applied because strong absorption water. Here we use gas-dynamic forces to generate free-flowing, sub-micron, sheets which are two orders magnitude thinner than anything previously reported. Optical, infrared, spectroscopies used characterize the sheets, found...
Abstract Hypoxia in solid tumors is thought to be an important factor resistance therapy, but the extreme microscopic heterogeneity of partial pressures oxygen (pO 2 ) between capillaries makes it difficult characterize scope this phenomenon without invasive sampling distributions throughout tissue. Here we develop a non-invasive method track spatial during fractionated radiotherapy, using oxygen-dependent quenching phosphorescence, probe Oxyphor PtG4 and radiotherapy-induced Cherenkov light...
Imaging Cherenkov emission during radiation therapy cancer treatments can provide a real-time, non-contact sampling of the entire dose field. The emitted signal generated is proportional to deposited dose, however, it affected by attenuation from intrinsic tissue optical properties patient, which in breast, ranges primarily adipose fibroglandular tissue. Patients being treated with whole-breast X-ray radiotherapy (n = 13) were imaged for 108 total fractions, establish correction factors...
Abstract Objective. Existing ultra-high dose rate (UHDR) electron sources lack independent dosimeters and a calibrated control system for accurate delivery. In this study, we aim to develop custom single-pulse monitoring real-time dose-based FLASH enabled clinical linear accelerator (Linac). Approach. A commercially available point scintillator detector was coupled gated integrating amplifier controller feedback loop. The programmed integrate each radiation pulse stop the beam when...
Ultra-high dose rate (UHDR) FLASH beams typically deliver at rates of >40 Gy/sec. Characterization these with respect to dose, mean rate, and per pulse requires dosimeters which exhibit high temporal resolution fast readout capabilities.A diode EDGE Detector a newly designed electrometer has been characterized for use in an UHDR electron beam demonstrated appropriateness radiotherapy dosimetry.Dose linearity, dependencies the were quantified compared including W1 scintillator detector,...
Diffraction before destruction using X-ray free-electron lasers (XFELs) has the potential to determine radiation-damage-free structures without need for crystallization. This article presents three-dimensional reconstruction of Melbournevirus from single-particle diffraction patterns collected at LINAC Coherent Light Source (LCLS) as well reconstructions simulated data exploring consequences different kinds experimental sources noise. The suffers a strong artifact in center particle. could...
Abstract Background While careful planning and pre‐treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way attain true delivered dose. Several countries outside US require IVD for quality assurance. However, elsewhere, manual labor time considerations of traditional dosimeters may be preventing frequent use clinic. Purpose This study expands upon previous research...
Imaging Cherenkov emission during radiotherapy permits real-time visualization of external beam delivery on superficial tissue. This signal is linear with absorbed dose in homogeneous media, indicating potential for quantitative dosimetry. In humans, the inherent heterogeneity tissue optical properties (primarily from blood and skin pigment) distorts linearity between detected dose. We examine to correct vasculature using spatial frequency domain imaging (SFDI) map large fields view....
The role and effect of stable Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4+</sup> centers in Ce-doped LuAG single crystal scintillator is further studied by means measurements several optical, luminescence scintillation characteristics. Two LuAG:Ce samples are compared: one them the dominating xmlns:xlink="http://www.w3.org/1999/xlink">4 +</sup> center stabilized high concentration Mg xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup>...
Abstract Objective. To demonstrates the ability of an ultra-fast imaging system to measure high resolution spatial and temporal beam characteristics a synchrocyclotron proton pencil scanning (PBS) system. Approach. An (1 kHz frame rate), intensified CMOS camera was triggered by scintillation sheet coupled remote trigger unit for on detection. The calibrated using linear ( R 2 > 0.9922) dose response single spot varying currents. Film taken used produce intensity absolute calibration. Main...
SignificanceFluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible detect naked eye. Such include tissue perfusion molecular phenotypic information about disease being resected. Conventional fluorescence-guided surgery relies on long, microsecond scale laser pulses excite fluorescent probes. However, this technique only provides two-dimensional information; crucial depth information,...
SignificanceProtoporphyrin IX (PpIX) delayed fluorescence (DF) is inversely related to the oxygen present in tissues and has potential as a novel biomarker for surgical guidance real-time tissue metabolism assessment. Despite unique promise of this technique, its successful clinical translation limited by low intensity emitted.AimWe developed systematic study ways increase PpIX DF signal through acquisition sampling changes, allowing optimized imaging at video rates.ApproachTo accomplish...
Abstract Background The interest in ultra‐high dose rate (UHDR) radiation therapy (RT) has grown due to its potential spare normal tissue. However, clinical application is hindered by dosimetry challenges, as current irradiators and dosimeters are not designed for UHDR's high fluence. To ensure safe treatment accurate delivery, real‐time quantification methods essential. Purpose We propose a novel scintillation imaging system vivo, pulse‐by‐pulse surface monitoring during delivery with...