A5043956788- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Radiation Detection and Scintillator Technologies
- Photoacoustic and Ultrasonic Imaging
- Breast Cancer Treatment Studies
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Atomic and Subatomic Physics Research
- bioluminescence and chemiluminescence research
- Radiation Effects in Electronics
- Cutaneous Melanoma Detection and Management
- Advanced Biosensing Techniques and Applications
- Brain Metastases and Treatment
- Cell Image Analysis Techniques
- Digital Radiography and Breast Imaging
- Management of metastatic bone disease
- Advances in Oncology and Radiotherapy
- Peptidase Inhibition and Analysis
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
Massachusetts General Hospital
2023-2024
University of Wisconsin–Madison
2023
Harvard University
2023
Dartmouth College
2018-2022
Imaging Cherenkov emission during radiation therapy cancer treatments can provide a real-time, non-contact sampling of the entire dose field. The emitted signal generated is proportional to deposited dose, however, it affected by attenuation from intrinsic tissue optical properties patient, which in breast, ranges primarily adipose fibroglandular tissue. Patients being treated with whole-breast X-ray radiotherapy (n = 13) were imaged for 108 total fractions, establish correction factors...
Imaging Cherenkov emission during radiotherapy permits real-time visualization of external beam delivery on superficial tissue. This signal is linear with absorbed dose in homogeneous media, indicating potential for quantitative dosimetry. In humans, the inherent heterogeneity tissue optical properties (primarily from blood and skin pigment) distorts linearity between detected dose. We examine to correct vasculature using spatial frequency domain imaging (SFDI) map large fields view....
. Clinical outcomes after proton therapy have shown some variability that is not fully understood. Different approaches been suggested to explain the biological outcome, but none has yet provided a comprehensive and satisfactory rationale for observed toxicities. The relatively recent transition from passive scattering (PS) pencil beam scanning (PBS) treatments significantly increased voxel-wise dose rate in therapy. In addition, distribution no longer uniform along cross section of target...
Imaging Cherenkov light during radiotherapy allows the visualization and recording of frame-by-frame relative maps dose being delivered to tissue at each control point used throughout treatment, providing one most complete real-time means treatment quality assurance. In non-turbid media, intensity is linear with surface deposited, however emission from patient well-known be reduced by absorbing components such as hemoglobin, fat, water, melanin, diffused scattering tissue. Earlier studies...
Significance: Optical imaging of Cherenkov emission during radiation therapy could be used to verify dose delivery in real-time if a more comprehensive quantitative understanding the factors affecting intensity developed. Aim: This study aims explore change diffuse with x-ray beam energy from irradiated tissue, both theoretically and experimentally. Approach: Derivation emitted signal was achieved using diffusion theory, experimental studies 6 18 MV x-rays were performed tissue phantoms...
Significance: The Cherenkov emission spectrum overlaps with that of ambient room light sources. Choice lighting devices dramatically affects the efficient detection during patient treatment. Aim: To determine optimal sources allowing imaging in normally lit radiotherapy treatment delivery rooms. Approach: A variety commercial and long-pass (LP) filters were surveyed for spectral band separation from red to near-infrared emitted by tissue. Their effects on signal-to-noise ratio (SNR),...
. To commission a proton, double-scattering FLASH beamline by maximizing efficiency and field size, enabling higher-linear energy transfer radiotherapy to cells small animals using spread-out Bragg peak (SOBP) treatment configuration. We further aim provide configuration guide for the design of future proton (DS) beamlines.
Tissue optical properties attenuate a substantial percentage of the light being detected during real-time Cherenkov acquisition, which distortsthe signal linearity previously observed with absorbed dose in homogeneous media. This hinders progression toward establishing quantitative dosimetry using imaging vivo. By spectrally weighting effective attenuation (μ<sub>eff</sub>) maps generated by multi-wavelength Spatial Frequency Domain Imaging (SFDI), it became possible to more successfully...
Cherenkov light emission from tissue undergoing radiation therapy is a complex function of the dose deposition and reduced by optical attenuation tissue. A diffusion theory based integral remitted presented, using assumption that only photons first 8 mm are able to appreciably escape surface. This depth restriction falls within linear build-up region for both electron photon beams used in radiotherapy. The resulting expression fluence formulated here indicates outgoing intensity dependent...
Abstract Cherenkov radiation (CR) is produced from all high energy sources and part of the dose delivery process in tissue. As such, CR a direct indicator recent years ability to image measure has provided number ways help with radiotherapy dosimetry tracking. This review provides an overview fundamental physical principles production transport tissue, along applications imaging that have seen significant development past few years.
Cherenkov light is emitted in response to therapeutic x-ray beam delivery for the treatment of breast cancer, and serves as a passive, non-contact approach measuring optical signal that intrinsically linear with dose. However, intensity attenuated due absorbers tissue (blood, pigment, radiodensity, etc.). If correction this attenuation were possible, then absolute dose imaging would be feasible. In study, planning CT scan was spatially sampled over area emitting Cherenkov, corrected for,...