A5037857781- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- HVDC Systems and Fault Protection
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Bone and Joint Diseases
- Cancer-related Molecular Pathways
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Abstract Background Metastasis is the main cause of mortality in cervical cancer (CC). Circular RNAs (circRNAs) have been demonstrated to play a crucial role carcinoma biology. However, expression and function circRNAs metastasis are still unclear. Methods In present study, we identified circRNA with an N6-methyladenosine (m6A) modification, circCCDC134, whose was increased CC tissues by circRNA-Seq qPCR. CircCCDC134 upregulation fine-tuned ALKBH5-mediated m6A which enhanced its stability...
Abstract Background Most patients with ovarian cancer (OC) treated platinum-based chemotherapy have a dismal prognosis owing to drug resistance. However, the regulatory mechanisms of circular RNA (circRNA) and p53 ubiquitination are unknown in platinum-resistant OC. We aimed identify circRNAs associated OC develop novel treatment strategy. Methods Platinum-resistant were screened through circRNA sequencing validated using quantitative reverse-transcription PCR cells tissues. The...
Background: The mechanism by which infiltrating CD8+ T lymphocytes in the tumour microenvironment influence survival of patients with ovarian cancer (OC) remains unclear. Methods: To identify biomarkers to optimise OC treatment, 13 immune-cell-line-associated datasets, RNA sequencing data, and clinical data from GEO, TCGA, ICGC were collected. Gene expression was assessed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) immunohistochemistry (IHC) staining....
Primary thyroid lymphoma (PTL) is a rare malignancy, and the literature limited to small case series reports. This study aimed assess epidemiologic characteristics, survival, prognostic factors of patients with PTL.We analyzed 2215 PTL from Surveillance, Epidemiology, End Results database medical records, between 1983 2015, as training cohort. We enrolled 105 Cancer Hospital, Chinese Academy Medical Sciences, for external validation The nomograms predicting 1-, 5-, 10-year overall survival...
Background: Palliative chemotherapy has been the mainstay treatment for patients with recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC). However, little is known about efficacy and toxicity of nimotuzumab (NTZ) – a monoclonal antibody drug targeting epidermal growth factor receptor plus (CT) versus CT alone these patients. Methods: The database at Cancer Hospital Chinese Academy Medical Sciences was queried diagnosed NPC who received without NTZ between 2004 2018. Treatment...
Globally, the incidence of cervical cancer (CC) is highest among all tumors female reproductive system. Numerous studies have shown that expression level microRNA (miRNA) highly correlated with cancer. This study aimed to establish a molecular prognostic model CC based on miRNAs in order provide more individualized treatment patients.Human tissues were selected from Cancer Hospital (Chinese Academy Medical Sciences and Peking Union College) for miRNA gene sequencing. transcriptome clinical...
Abstract Some patients with endometrial cancer (EC) suffer from limited survival benefits after immunotherapy, suggesting that there may be a specific pattern associated immunotherapy. Immune-related genes were extracted The Cancer Genome Atlas databases. We analyzed the differences among immune subtypes (ISs) in distribution of tumor mutational burden, chemotherapy-induced response markers, checkpoint-related genes, and chemotherapy. applied dimensionality reduction defined landscape EC....
<h3>Background</h3> Patients with rheumatoid arthritis (RA) are associated an increased risk of periarticular and generalized bone loss. A 3D high resolution peripheral quantitative computed tomography (HR-pQCT) system has been developed to perform in vivo human measurements geometry, volumetric mineral density (vBMD) microarchitecture on skeletal sites such as the radius tibia. HR-pQCT also holds great potential measure morphological, densitometric microstructural changes bones RA....
<h3>Background</h3> Generalized bone loss at axial and peripheral is a common feature of rheumatoid arthritis (RA) one the determinants fracture risk. The relationship between decreased areal mineral density (aBMD) less clear in RA than postmenopausal osteoporosis. High-resolution quantitative computed tomography (HR-pQCT) an vivo imaging technique capable assessing volumetric BMD (vBMD) microarchitecture cortical trebecular distal radius. <h3>Objectives</h3> To assess density, strength...
Background: Advanced head and neck cancer (HNC) is a malignancy with poor prognosis. Due to the impact of tumour heterogeneity, different individuals experience efficacies immunotherapy. Therefore, it important understand potential benefit population for immunotherapy.Methods: Baseline blood samples were collected from 26 patients advanced HNC receiving immunotherapy at Cancer Hospital Chinese Academy Medical Sciences, along 50 healthy control samples. To identify copy number variations...