A5082958935- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Maritime Ports and Logistics
- Energetic Materials and Combustion
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Thermal and Kinetic Analysis
- Global trade and economics
- Rocket and propulsion systems research
- Cancer-related molecular mechanisms research
- Maritime Transport Emissions and Efficiency
- Power Systems and Renewable Energy
- Economic Zones and Regional Development
- Crystallography and molecular interactions
- Law, logistics, and international trade
- Nanoparticle-Based Drug Delivery
- Fullerene Chemistry and Applications
- Berberine and alkaloids research
- Graphene research and applications
- Cancer, Hypoxia, and Metabolism
- Carbon Nanotubes in Composites
- Circular RNAs in diseases
- Alkaloids: synthesis and pharmacology
- Organometallic Complex Synthesis and Catalysis
Beijing Tongren Hospital
2024-2025
Capital Medical University
2024-2025
Nanchang University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Central South University
2024
University of Illinois Chicago
2022-2024
Fudan University
2009-2024
Copenhagen Business School
2016-2024
Weihai Maternal and Child Health Hospital
2024
Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved various human cancers evolved rapidly Tibetans six Tibetan domestic mammals compared to reciprocal lowlanders. Furthermore, m6A modified mRNA binding protein YTHDF1, one of evolutionary positively selected for high-altitude adaptation is amplified cancers, including non-small cell lung cancer (NSCLC). We show YTHDF1 deficiency inhibits NSCLC proliferation xenograft tumor...
Abstract Chinese goldthread ( Coptis chinensis Franch.), a member of the Ranunculales, represents an important early-diverging eudicot lineage with diverse medicinal applications. Here, we present high-quality chromosome-scale genome assembly and annotation C. . Phylogenetic comparative genomic analyses reveal phylogenetic placement this species identify single round ancient whole-genome duplication (WGD) shared by Ranunculaceae. We characterize genes involved in biosynthesis...
Mitochondria are high dynamic organelles with frequent fission and fusion. Here, we found hypoxia stimulated Drp1 expression, mitochondrial migration in metastatic MDA-MB‑231 cells, but not non-metastatic MCF-7 cells. Inhibition of Drp1-dependent by Mdivi-1 or silencing attenuated hypoxia-induced On the other hand, cisplatin induced significant apoptosis also efficiently prevented cisplatin-induced MMP decrease, ROS production Our data suggest that only regulates breast cancer facilitates...
Non-small cell lung cancer (NSCLC) is the most common type of human cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play important roles in NSCLC, limiting efficacies achieved.Bioinformatics methods were used identify differential long non-coding RNA expression NSCLC. Real-time RT-PCR experiments examine pattern lncRNA PKMYT1AR, miR-485-5p. Both vitro vivo functional assays performed investigate role...
Abstract Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs dogs at both high low altitudes, including 73 generated this study, to disentangle mechanisms underlying local adaptation of mammals. Although molecular convergence is comparatively rare DNA sequence level, found convergent signature positive selection gene particularly...
Because of the lack specific targets, highly aggressive triple negative breast cancer (TNBC) is unable to benefit from endocrine therapy or conventional targeting therapy. Even worse, current diagnostic and therapeutic approaches have limited value for TNBC. Therefore, developing TNBC-specific theranostic probes accurate diagnosis further selective will build a powerful toolbox TNBC management. In this contribution, we developed sequential strategy enhance specificity theranostics. system,...
Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin biguanide drug that exerts strong effects on multiple diseases. This study aims to evaluate the protective effect of metformin against retinal I/R its underlying mechanism. induced reduction retina thickness cell number ganglion layer, alleviated I/R-induced injury. Both simulated (SIR) R28 cells down-regulated...
Abstract Tertiary lymphoid structures (TLSs) have been associated with favorable immunotherapy responses and prognosis in various cancers. Despite their significance, quantification using multiplex immunohistochemistry (mIHC) staining of T B lymphocytes remains labor-intensive, limiting its clinical utility. To address this challenge, we curated a dataset from matched mIHC H&E whole-slide images (WSIs) developed deep learning model for automated segmentation TLSs. The achieved Dice...
The synergistic effect of combination treatment with COX-2 inhibitors and chemotherapy may be another promising therapy regimen in the future colorectal cancer. Curcumin, a major yellow pigment turmeric which is used widely all over world, inhibits growth human colon cancer cell line HT-29 significantly specifically expression protein. However, worldwide exposure populations to curcumin raised question whether this agent would enhance or inhibit effects chemotherapy. In report, we evaluated...
Abstract Colon cancer (CC) is one of the major malignancies worldwide, whose pathogenesis complex and requires accumulated alteration multiple genes signaling pathways. Condensins are multi-protein complexes that play pivotal roles in chromosome assembly segregation during mitosis, meiosis even tumorigenesis. Using tissue microarrays by immunohistochemistry hematoxylin–eosin staining, we found non-SMC condensin I subunit H (NCAPH) colon cancerous tissues was higher than all corresponding...
Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned a concentration of 0.1 μg/mL dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation Wnt signaling pathway differentiation but did not affect neuroblastoma cells.
Purpose: Lung cancer is the leading cause of related deaths worldwide.We have previously identified many differentially expressed genes (DEGs) from large scale pan-cancer dataset using Cross-Value Association Analysis (CVAA) method.Here we focus on Progestin and AdipoQ Receptor 4 (PAQR4), a member progestin adipoQ receptor (PAQR) family localized in Golgi apparatus, to determine their clinical role mechanism development non-small cell lung (NSCLC).Methods: The protein expression profile...
Early detection of drug-induced acute kidney injury (AKI) is crucial for effective treatment and prevention further injury. It remains challenging, however, because the lack activatable indicators with multimodality imaging capability that could increase accuracy diagnosis by mutual verification. Herein, we report an probe, FDOCl-22, enabled dual-modality early-stage AKI. FDOCl-22 was completely soluble in water highly sensitive to hypochlorous acid (HOCl). Dramatic increases both...
China is a land with abundant wind resources. According to the latest official release of national energy resource assessment results, 50-m-high potential amounts about 2,580 GW, which 2,380 GW onshore and 200 offshore in 5-25-m range water depth. The areas suitable for developing large-scale power include Northeast, Northwest, North China, as well coastal provinces Jiangsu Shandong, where accounts 80% whole country, shown Figure 1. (This article does not contain data information Hong Kong...
Glioblastoma multiform (GBM) is a highly aggressive primary brain tumor. Exosomes derived from glioma cells under hypoxic microenvironment play an important role in tumor biology including metastasis, angiogenesis and chemoresistance. However, the underlying mechanisms remain to be elucidated. In this study, we aimed explore of connexin 43 on exosomal uptake hypoxia. U251 were exposed 3% oxygen achieve hypoxia, expression levels HIF-1α Cx43, involved colony formation proliferation assessed....