A5003733937- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- HVDC Systems and Fault Protection
- Cancer Immunotherapy and Biomarkers
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Mechanisms of cancer metastasis
- Educational Innovations and Challenges
- Educational Technology and Pedagogy
- Melanoma and MAPK Pathways
- Neurogenetic and Muscular Disorders Research
- PI3K/AKT/mTOR signaling in cancer
- ATP Synthase and ATPases Research
- Viral-associated cancers and disorders
University of Florida Health
2023-2025
Heilongjiang University of Technology
2025
Kunming Institute of Zoology
2020-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2020-2024
University of Florida
2024
International Peace Maternity & Child Health Hospital
2023
Shanghai Jiao Tong University
2023
Suizhou Central Hospital
2023
Kunming Medical University
2022
Non-small cell lung cancer (NSCLC) is the most common type of human cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play important roles in NSCLC, limiting efficacies achieved.Bioinformatics methods were used identify differential long non-coding RNA expression NSCLC. Real-time RT-PCR experiments examine pattern lncRNA PKMYT1AR, miR-485-5p. Both vitro vivo functional assays performed investigate role...
Purpose: Lung cancer is the leading cause of related deaths worldwide.We have previously identified many differentially expressed genes (DEGs) from large scale pan-cancer dataset using Cross-Value Association Analysis (CVAA) method.Here we focus on Progestin and AdipoQ Receptor 4 (PAQR4), a member progestin adipoQ receptor (PAQR) family localized in Golgi apparatus, to determine their clinical role mechanism development non-small cell lung (NSCLC).Methods: The protein expression profile...
Lung adenocarcinoma (LUAD) is the most common type of lung cancer, accounting for approximately 85% pulmonary malignancies. Emerging evidence has demonstrated that ferroptosis plays a central role in both immunities as well tumor proliferation. However, clinical significance, immunological function, and upstream modulatory mechanism ferroptosis-related genes LUAD remain unclear. Here, we utilized various bioinformatics data to identify differentially expressed (DEGs) prognosis-related (FRGs)...
Gliomas are the most aggressive type of malignant brain tumors.Recent studies have demonstrated that existence glioma stem cells (GSCs) is critical for recurrence, metastasis, and chemo-or radio-therapy resistance.Temozolomide (TMZ) has been used as an initial therapy gliomas.However, overall survival time still limiting due to lack effective targets treatment options.Therefore, identifying novel biomarkers gliomas, especially GSCs, important improve clinical outcome in future.In this study,...
LncRNA plays a pivotal role in the stemness and drug resistance of lung cancer. Here, we found that lncRNA-AC026356.1 was upregulated stem spheres chemo-resistant cancer cells. Our fish assay also shows AC026356.1 predominantly located cytoplasm cells does not have protein-coding potential. Silencing significantly inhibited proliferation migration but increased apoptosis A549-cisplatin (DDP) Additionally, IGF2BP2 positively regulated stem-like Further mechanistic investigation revealed...
Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing on the prognosis, upstream regulation mechanism, and immunological roles of across diverse tumor types. In this study, we found was elevated human pan-cancer analysis, high expression correlated with poor prognosis. addition, markedly associated mutation burden (TMB), microsatellite instability (MSI), immune cell infiltration, drug sensitivities. Finally, showed...
Abstract The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in tissues and cell lines due to hypermethylation its promoter region, show patients with CM expressing high levels MrgprF exhibit an improved clinical outcome. We demonstrate forced expression inhibits tumor proliferation, migration, xenograft growth, metastasis. On the contrary, knockdown promotes proliferation...
Striatin-interacting protein 2 (STRIP2), also called Fam40b, has been reported to regulate tumor cell growth. But the role of STRIP2 in lung adenocarcinoma (LUAD) not discovered clearly. Thus, aim our study is explore function and underlying mechanism LUAD. Expression was determined using Cancer Genome Atlas (TCGA), GTEx, Ualcan, Human Protein Altas databases. The Correlation survival detected by PrognoScan Kaplan-Meier plotter Besides, correlation between expression immune infiltration as...
Lung cancer is the most common with high mortality. Increasing evidence has demonstrated that nonstructural maintenance of chromosomes condensin I complex subunit G (NCAPG) plays a crucial role in progression human cancers. However, biological function and underlying mechanism NCAPG non-small cell lung (NSCLC) are still unclear. Here, we utilized diverse public databases to analyze expression pan-cancer. We found was highly expressed various cancers, especially NSCLC. significantly...
Abstract N4‐acetylcytidine (ac4C) modification is a crucial RNA widely present in eukaryotic RNA. Previous studies have demonstrated that ac4C plays pivotal role viral infections. Despite numerous highlighting the strong correlation between and cancer progression, its detailed roles molecular mechanisms normal physiological processes progression remain incompletely understood. This review first outlines key regulatory enzyme mediating modification, N‐acetyltransferase 10 (NAT10), including...
Under the new liberal arts context, improving writing ability and comprehensive quality has become an important goal in development of higher education. Traditional educational models often focus on transmission knowledge individual disciplines while neglecting integration students' overall qualities. With rise education concept, interdisciplinary collaboration, integration, competency-driven teaching methods have gradually core reform. This study aims to explore how, from perspective, can...
A growing number of studies have focused on investigating microRNAs as crucial regulators in the progression multiple cancer types. Nevertheless, biological effects and immunological role miR-125b-5p non-small cell lung (lung adenocarcinoma, LUAD) not been determined. The present study aimed to examine function proliferation outcomes LUAD patients. We utilized diverse public databases analysis expression, prognosis, diagnostic value, immune cancer. growth curve, colony formation, flow...
We revealed that SNX20 was up-regulated in LGG, and its higher expression associated with adverse clinical outcomes poor characteristics, including WHO grade, IDH mutation, 1p/19q codeletion, primary therapy outcome. The results of the Cox regression analysis an independent factor for prognosis low-grade glioma. Meanwhile, we also established a nomogram based on to predict 1-, 3-, or 5-year survival LGG patients. Furthermore, found DNA hypomethylation overexpression LGG. In addition,...
Gliomas account for 75% of all primary malignant brain tumors in adults and result high mortality. Accumulated evidence has declared the minichromosome maintenance protein complex (MCM) gene family plays a critical role modulating cell cycle DNA replication stress. However, biological function clinic characterization nine MCM members low-grade glioma are not yet clarified. In this study, we utilized diverse public databases, including The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA),...
Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in initiation progression various cancers. LncRNA-AC099850.3 a novel lncRNA that abnormally expressed diverse cancer types including LUAD. However, clinical significance, prognostic value, diagnostic immune role, potential biological function AC099850.3 LUAD remain elusive. In this study, we found was highly...
MiRNA-30a-5p is a microRNA found to be decreased in various human cancers, including lung adenocarcinoma (LUAD). However, the molecular mechanisms of miRNA-30a-5p involve progression LUAD remains unclear. In this study, we that expression was significantly cells lines, tissues, and peripheral blood serum. Besides, patients with exhibit worse clinical outcomes compared higher expression, associated advanced outcomes. Receiver operating characteristic (ROC) curve analysis showed an area under...
Platelet-activating factor acetylhydrolase 1B3 (PAFAH1B3) plays a critical role in cancer initiation, metastasis, and progression; however, it remains unknown how PAFAH1B3 impacts diagnosis prognosis or regulates the immune response to different types of cancer. In this study, was elevated human pan-cancer, correlated with greater pathology poor prognosis, particular for non-small cell lung (NSCLC) liver hepatocellular carcinoma (LIHC). addition, expression positively associated tumor...
Background: Low grade glioma is one of the most common lethal cancers in human nervous system. Emerging evidence has demonstrated that homeobox A cluster (HOXA) gene family plays a critical role transcriptional regulation as well cancer initiation and progression. However, expression, biological functions upstream regulatory mechanism 11 HOXAs low are not yet clear. Methods: In this study, we utilized various public databases bioinformatics analyzed, including TCGA, CGGA, Rembrandt, HPA,...