A5063269762- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Laser Applications in Dentistry and Medicine
- RNA Research and Splicing
- Exercise and Physiological Responses
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Medical and Biological Ozone Research
- DNA and Nucleic Acid Chemistry
- Atrial Fibrillation Management and Outcomes
- Corrosion Behavior and Inhibition
- Extracellular vesicles in disease
- Power Transformer Diagnostics and Insulation
- Hydrogen's biological and therapeutic effects
- Glaucoma and retinal disorders
- Big Data Technologies and Applications
- Aquatic Ecosystems and Phytoplankton Dynamics
Kunming Medical University
2021-2025
First People's Hospital of Yunnan Province
2019-2025
Kunming University of Science and Technology
2019-2025
Hebei Medical University
2023-2024
Fujian Medical University
2024
Affiliated Eye Hospital of Wenzhou Medical College
2022
Wenzhou Medical University
2022
Second Affiliated Hospital of Kunming Medical College
2022
Hebei General Hospital
2022
National Clinical Research Center for Digestive Diseases
2022
BackgroundMyocardial ischemia/reperfusion injury (MI/RI) can lead to impaired cardiac function. Quercetin (Que) has a positive effect and improves MI/RI. Sirtuin-3 (Sirt3) is deacetylase that ameliorates oxidative stress associated with This study aimed investigate the molecular mechanism by which Que protects function against MI/RI through Sirt3 signaling pathway.MethodsWe conducted experiments constructing hypoxia/reoxygenation (H/R) cardiomyocytes rat models. H9C2 cells were transfected...
Lung adenocarcinoma (LUAD) is a common type of lung cancer and one the leading causes death worldwide. Long non-coding RNAs (lncRNAs) play crucial role in tumors. The purpose this study was to explore expression lncRNAs associated with RNA methylation modification their prognostic value LUAD. sequencing clinical data were downloaded from Cancer Genome Atlas dataset, messenger annotated by Ensemble. related regulators (RMlncRNAs) filtered Pearson correlation analysis between differentially...
The single-nucleotide polymorphism SLC39A6 rs1050631 is strongly implicated in esophageal squamous cell carcinoma, leading us to question whether it may also play a role gastric adenocarcima (GA).We genotyped the 512 patients who underwent GA resection. All study subjects lived an area of China with high incidence. Genotypes were examined for possible correlation survival and recurrence. potential involvement cancer was explored clinical samples culture studies.Multivariable analysis showed...
Gliomas account for 75% of all primary malignant brain tumors in adults and result high mortality. Accumulated evidence has declared the minichromosome maintenance protein complex (MCM) gene family plays a critical role modulating cell cycle DNA replication stress. However, biological function clinic characterization nine MCM members low-grade glioma are not yet clarified. In this study, we utilized diverse public databases, including The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA),...
Previous studies indicated that microRNA-125b (miR-125b) has an important role in the progression of Ewing's sarcoma (ES).The purpose current study was to examine expression changes miR-125b serum ES patients and evaluate if level could serve as a new biomarker for ES.This performed on who underwent surgical resection at our hospital between 2005 2013 after initial diagnosis ES.We measured levels 63 with 126 healthy control using real-time quantitative reverse transcriptase-PCR (qRT-PCR)...
Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in initiation progression various cancers. LncRNA-AC099850.3 a novel lncRNA that abnormally expressed diverse cancer types including LUAD. However, clinical significance, prognostic value, diagnostic immune role, potential biological function AC099850.3 LUAD remain elusive. In this study, we found was highly...
Abstract Background HER2-targeted therapies have improved the outcomes of HER2-positive gastric cancer (GC), yet resistance remains a challenge. We sought to explore effects reversible and irreversible HER2 tyrosine kinase inhibitors (TKIs) alone or in combination with HER2-targeting antibody drug conjugate trastuzumab deruxtecan (T-Dxd). Methods The HER2-TKIs on downstream signaling were evaluated via Western blotting. Proteasomal co-immunoprecipitation assays performed role proteasomal...
This paper focuses on the relationship between software quality standards and assurance. According to engineering international standard ISO/IEC 25000 series localization process in China, how ensure by technology management is explored. It pointed out that needs be guaranteed standard, assessment test mechanism.
Purpose: To compare the diagnostic power of strip meniscometry (SM), Schirmer test (ST), and tear meniscus (TM) in mild dry eye disease (DED) to evaluate association with DED-related parameters. Methods: Forty left eyes DED 40 control participants were investigated. All underwent a comprehensive ocular surface examination, including Ocular Surface Disease Index (OSDI), fluorescein film break-up time (FTBUT), staining grades, meiboscores, volume examinations, SM, ST, height (TMH),...
A novel extrinsic Fabry–Perot interferometric (EFPI) ultrasonic sensor is developed that can detect signals of partial discharge (PD) in high-voltage electrical equipment under different temperature and pressure conditions. The unique structure the able to balance difference between two sides quartz diaphragm driven by density insulating medium, inner surface end face optical fiber are coated, thus considerably improving sensitivity. Experiments performed on at temperatures measurement...
Coronary artery bypass graft (CABG) is one of the primary methods treating coronary heart disease (CHD); however, vein restenosis a major limiting factor effectiveness CABG. Emerging evidence has indicated that miR‑423 associated with vascular diseases. Additionally, upregulation disintegrin and metalloproteinase thrombospondin motifs‑7 (ADAMTS‑7) contributes to neointima formation by promoting proliferation migration smooth muscle cells inhibiting endothelial cells. The aim present study...
Lung cancer is the leading cause of cancer-related death worldwide. Therapies for lung have relatively poor outcomes and need to be improved. immune cell infiltration associated RNA (LCIIAR) a long noncoding (lncRNA), which overexpressed in human cancers. However, clinical significance functional role LCIIAR Adenocarcinoma remain unclear. Here, we identified novel non-coding (ENSG00000256802), termed (lung lncRNA), up-regulated tissue lines. We show that increase expression correlated with...
It has been widely demonstrated that long non-coding RNA H19 (lncRNA H19) plays an important role in the progression of various human cancers. However, associations common genetic variations with recurrence and survival gastric adenocarcinoma this lncRNA remain largely unknown.The rs2839698 single nucleotide polymorphism (SNP) was genotyped tissue samples from 441 patients T3 who had surgical operations between 2004 to 2009, relationships different genotypes after surgery alone (n = 156) or...
RYR2 mutation is clinically frequent in non-small cell lung cancer (NSCLC) with its function being elusive. We downloaded squamous carcinoma and adenocarcinoma samples from the TCGA database, split into mutant group (n = 337) wild 634), established Kaplan-Meier curves. The results showed that lived longer than (p 0.027). Weighted gene co-expression network analysis (WGCNA) of differentially expressed genes (DEGs) yielded prognosis-related genes. Five mRNAs 10 lncRNAs were selected to build...
Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it leading cause of cancer-related deaths worldwide. NCAPG2 (non-SMC condensin II complex subunit G2) has been shown to be upregulated in various human cancers. Nevertheless, underlying biological function potential mechanisms driving progression LUAD remain unclear. In this study, we investigated role found that expression tissues was significantly higher than adjacent normal tissues. Kaplan-Meier survival analysis...
This article is based on the ecological security of Hadoop cluster.Combined with practical application Kerberos authentication system in cluster, we propose a multi node HA (High Available) configuration Kerberos, realize Master-Master-Slave design mode and increase redundant nodes storage.Based characteristics dual Master, set timed tasks, execute scripts time, carry out data dump Master nodes, prevent single failure, avoid failure system.We use Slave to one way backup storage from...
The present study investigated the expression and function of long noncoding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) related to gastric cancer (GC), based on previous results from a microarray analysis.Real-time quantitative polymerase chain reaction (qPCR) was used verify AFAP1-AS1 in 97 fresh GC tissues paired non-GC tissues, as well six different cell lines (BGC-823, SGC-7901, MGC-803, AGS, MKN-45, MKN-28). levels were subsequently correlated with...