A5100347418- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- RNA Research and Splicing
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- HIV/AIDS drug development and treatment
- Medical Research and Treatments
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Natural Compounds in Disease Treatment
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- Educational Reforms and Innovations
- Genetics and Neurodevelopmental Disorders
- Corporate Finance and Governance
- Autophagy in Disease and Therapy
Chinese Academy of Agricultural Sciences
2022-2025
Institute of Crop Sciences
2022-2025
Tongde Hospital of Zhejiang Province
2017-2024
Anhui University of Traditional Chinese Medicine
2024
Guilin Medical University
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Shandong Women’s University
2020-2024
Wuhan University of Science and Technology
2020-2023
BGI Genomics
2021-2023
Abstract Opiates exacerbate human immunodeficiency virus type 1 (HIV‐1) Tat 1‐72 ‐induced release of key proinflammatory cytokines by astrocytes, which may accelerate HIV neuropathogenesis in opiate abusers. The monocyte chemoattractant protein‐1 (MCP‐1, also known as CCL2), particular, is potentiated opiate–HIV interactions vitro. Although MCP‐1 draws monocytes/macrophages to sites CNS infection, and activated monocytes/microglia factors that can damage bystander neurons, the role...
Significance DOT1L is a histone methyltransferase that catalyzes H3K79 methylation, chromatin modification correlated with active transcription. Inhibition of DOT1L’s catalytic activity has been studied for cancer therapy; however, the mechanisms underlying its function in development and pathogenesis remain elusive. To understand catalytic-dependent catalytic-independent functions DOT1L, we generated dead null embryonic stem cells found but not activity, required establishing proper...
Transfer RNA-derived RNA fragments (tRFs) belong to non-coding RNAs (ncRNAs) discovered in most carcinomas. Although some articles have demonstrated the characteristics of tRFs gastric carcinoma (GC), underlying mechanisms still need be elucidated. Meanwhile, it was reported that MAPK pathway momentous GC progression. Thus we focused on investigating whether tRF-Glu-TTC-027 could act as a key role progression with regulation pathway. We collected data tRNA-derived expression profile from six...
Mitochondrial metabolism plays a pivotal role in various cellular processes and fibrosis. However, the mechanism underlying mitochondrial metabolic function liver fibrosis remains poorly understood. In this study, we determined whether mediates using cells, animal models, clinical samples to elucidate potential effects of We report that AlkB Homolog 5 (ALKBH5) decreases membrane (MMP) oxygen consumption rate (OCR), suppresses fission hepatic stellate cell (HSC) proliferation migration...
Background Non-coding RNAs (ncRNAs), including small nucleolar (snoRNAs), are widely involved in the physiological and pathological processes of human beings. While up to date, although considerable progress has been achieved ncRNA-related pathogenesis non-small cell lung cancer (NSCLC), underlying mechanisms biological significance snoRNAs NSCLC still need be further clarified. Methods Quantitative real-time polymerase chain reaction or RNAscope was performed verify expression Small...
pre-mRNA processing factor 3 (PRPF3) is an RNA binding protein in a core component of the exon junction complex.Abnormal PRPF3 expression potentially associated with carcinogenesis.However, biological role hepatocellular carcinoma (HCC) remains to be determined.We analyzed via multiple gene databases and identified its genetic alterations functional networks using cBioPortal.Co-expressed genes regulators were LinkedOmics.The correlations between cancer immune infiltrates investigated Tumor...
Piwi-interacting RNAs (piRNAs/piRs) are small non-coding that play important roles in stablizing genome through silencing transposable genetic elements. The piR-651 was reported to be dysregulated several human solid cancer tissues, such as gastric and lung cancers. However, the role of piRNA-651 carcinogenesis breast has not been defined. We found highly expressed tissues cell lines. Overexpression facilitated proliferation invasion, restrained apoptosis percentage arrested cells G0/G1...
Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing on the prognosis, upstream regulation mechanism, and immunological roles of across diverse tumor types. In this study, we found was elevated human pan-cancer analysis, high expression correlated with poor prognosis. addition, markedly associated mutation burden (TMB), microsatellite instability (MSI), immune cell infiltration, drug sensitivities. Finally, showed...
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HIV subtypes convey important epidemiological information and possibly influence the rate of disease progression. In this study, progression in patients infected with CRF01_AE, CRF07_BC, subtype B was compared largest molecular epidemiology study ever done China. A national data set pol sequences assembled by pooling from public databases Beijing laboratory network. Logistic regression used to assess factors associated risk AIDS at diagnosis ([AIDSAD], defined as a CD4 count < 200 cells/µL)...
Abstract Epigenetic modifications of histones are associated with development and pathogenesis disease. Existing approaches cannot provide insights into long-range interactions represent the average chromatin state. Here we describe BIND&MODIFY, a method using long-read sequencing for profiling histone transcription factors on individual DNA fibers. We use recombinant fused protein A-M.EcoGII to tether methyltransferase M.EcoGII binding sites label neighboring regions by methylation....
The booming of the digital economy has sped up development several industries. Through transformation, companies are continuously enhancing their capacity to adjust external economic environment, which affects every facet business. However, there is a scarcity comprehensive analysis research on hotspots, trends and opportunities consequences Enterprise Digital Transformation (EDT). Therefore, this study uses CiteSpace visually analyze knowledge network based sample 817 publications from 2018...
RNA m6A methylation installed by methyltransferases plays a crucial role in regulating plant growth and development environmental stress responses. However, the underlying molecular mechanisms of involved seed germination responses are largely unknown. In present study, we surveyed global rice under salt control (no stress) using an osmta1 mutant its wild type. The knockout OsMTA1 resulted decreased level delayed germination, together with increased oxidative damage osmta1-1 mutant,...
It is well established that the proto-oncogene, <i>bcl-2</i>, can prevent apoptosis induced by a variety of factors. Regarding mechanism which BCL-2 prevents cell death, one theory suggests it acts protecting cells from oxidative stress. In lens system, stress-induced implicated in cataractogenesis. To explore possibility anti-apoptotic gene therapy development for cataract prevention and also to further test anti-oxidative stress action, we have introduced human <i>bcl-2</i> into an...
Lung cancer has one of the highest mortalities any worldwide. Triptolide (TP) is a promising tumor suppressor extracted from Chinese herb Tripterygium wilfordii. Our previous proteomics analysis revealed that TP significantly interfered with ribosome biogenesis pathway; however, underlying molecular mechanism remains poorly understood. The aim present study was to determine TP's anticancer effect by investigating association between ribosomal stress and p53 activation. It found induces...
Triptolide (TP) is a diterpenoid triepoxide extracted from the traditional Chinese medical herb Tripterygium wilfordii that exerts prominent broad-spectrum anticancer activity to repress proliferation and induce cancer cell apoptosis through various molecular pathways. We previously observed TP inhibits progression of A549 cells pancreatic (PNCA-1) in vitro. However, complex mechanism underlying not well understood.To explore mechanisms by which induces lung apoptosis, we investigated...
Histone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones stable manner, ensuring the accurate and efficient execution of DNA replication, repair transcription. Retinoblastoma binding protein (RBBP)4 RBBP7 represent crucial pair histone chaperones, which not only govern molecular behavior H3 H4, but also participate functions several complexes, such as polycomb repressive complex 2 nucleosome remodeling deacetylase, thereby regulating...
<em>Mycoplasma pneumoniae</em> (MP) is a common pathogen that can cause respiratory infections. MP pneumonia (MPP) leads to numerous complications, including lung injury and even death. The present study aimed investigate the protective effects of Baicalin treatment on infection‑induced molecular mechanism underlying these effects. Briefly, after mice were infected intranasally by treated with (80 mg/kg), serum levels MP‑immunoglobulin M (IgM) detected ELISA. expression C‑reactive protein...
Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease of unknown etiology. The epigenetic regulation N6-methyladenosine (m6A) modification in immunity emerging. However, few studies have focused on SLE and m6A immune regulation. In this study, we aimed to explore potential integrated model SLE. models were constructed based RNA-seq data A consensus clustering algorithm was applied reveal the m6A-immune signature using principal component analysis (PCA). Univariate...