A5010130989- RNA modifications and cancer
- Cancer-related gene regulation
- Trace Elements in Health
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Estrogen and related hormone effects
- Infectious Encephalopathies and Encephalitis
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- interferon and immune responses
- HVDC Systems and Fault Protection
- Heavy Metal Exposure and Toxicity
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Caveolin-1 and cellular processes
- Thyroid Disorders and Treatments
- Breast Lesions and Carcinomas
- Reproductive System and Pregnancy
- Testicular diseases and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Traditional Chinese Medicine Studies
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
Anhui University of Traditional Chinese Medicine
2007-2025
Inner Mongolia University
2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2009-2024
First Hospital of Jilin University
2017-2024
Jilin University
2017-2024
Sun Yat-sen University Cancer Center
2009-2024
Institute of Precision Mechanics
2024
Zhongshan People's Hospital
2024
Union Hospital
2008-2023
Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The transfer (tRNAs) the most heavily modified RNA species cells; however, little is known about functions of tRNA In this study, we uncovered that expression levels N7-methylguanosine (m7G) methyltransferase complex components methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) significantly elevated lung cancer samples negatively patient prognosis. Impaired m7G modification upon METTL1/WDR4...
Abstract Background N 7 ‐methylguanosine (m G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism m G tRNA hepatocellular carcinoma (HCC) remain poorly understood. Methods prognostic value expression level methyltransferase complex components methyltransferase‐like protein‐1 (METTL1) WD repeat domain 4 (WDR4) HCC were evaluated using clinical samples TCGA data. biological functions mechanisms progression studied...
Abstract Mis-regulated RNA modifications promote the processing and translation of oncogenic mRNAs to facilitate cancer progression, while molecular mechanisms remain unclear. Here we reveal that tRNA m 7 G methyltransferase complex proteins METTL1 WDR4 are significantly up-regulated in esophageal squamous cell carcinoma (ESCC) tissues associated with poor ESCC prognosis. In addition, progression via activity vitro vivo. Mechanistically, or knockdown leads decreased expression G-modified...
Interplay between innate and adaptive immune cells is important for the antitumor response. However, tumor microenvironment may turn suppressive, associated macrophages are playing a role in this transition. Here, we show that CD276, expressed on tumor-associated (TAM), play diminishing response against tumors. Using model of tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine BLCA male mice genetic ablation CD276 TAMs blocks efferocytosis enhances expression major histocompatibility...
Aberrant RNA modifications are frequently associated with cancers, while the underlying mechanisms and clinical significance remain poorly understood. Here, we find that ac4C acetyltransferase NAT10 is significantly upregulated in esophageal cancers (ESCAs) poor ESCA prognosis. In addition, using cell lines mouse models, confirm critical functions of promoting tumorigenesis progression vitro vivo. Mechanistically, depletion reduces abundance ac4C-modified tRNAs decreases translation...
Abstract Background The molecular mechanisms of the development and progression bladder cancer are poorly understood. objective this study was to analyze expression Bmi-1 protein its clinical significance in human cancer. Methods We examined mRNA by RT-PCR Western blot, respectively 14 paired cancers adjacent normal tissues. 137 specimens 30 tissue determined immunohistochemistry. Statistical analyses were applied test relationship between Bmi-1, clinicopathologic features prognosis. Results...
Lolium rigidum is an obligately cross-pollinated, genetically diverse species and economically important herbicide resistance-prone weed. Our previous work has demonstrated that recurrent selection of initially susceptible L. populations with low rates results in rapid resistance evolution. Here we report on the mechanisms endowing low-dose-selected diclofop-methyl rigidum. Results showed was not due to target-site ACCase mutations or overproduction, differential leaf uptake translocation....
Esophageal cancer is a lethal malignancy with high mortality rate, while the molecular mechanisms underlying esophageal pathogenesis are still poorly understood. Here, we found that N6-methyladenosine (m<sup>6</sup>A) methyltransferase-like 3 (METTL3) significantly upregulated in squamous cell carcinoma (ESCC) and associated poor patient prognosis. Depletion of METTL3 results decreased ESCC growth progression <i>in vitro</i> vivo</i>. We further established initiation models using...
The Pax7+ muscle stem cells (MuSCs) are essential for skeletal homeostasis and regeneration upon injury, while the molecular mechanisms underlying cell fate determination still not fully understood. N6-methyladenosine (m6A) RNA modification is catalyzed by METTL3 plays important functions in posttranscriptional gene expression regulation various biological processes. Here, we generated cell-specific conditional knockout mouse model revealed that significantly inhibits proliferation of blocks...
Macroautophagy/autophagy, a physiological process that is involved in tumorigenesis, regulated at genetic and epigenetic levels. Emerging reports suggest aberrant RNA modifications cause dysregulated autophagy affect while the role of regulation cancers remains unclear. In recent study, we describe new for tRNA m7G methyltransferase complex components METTL1 WDR4 as negative regulators MTORC1-mediated esophageal squamous cell carcinoma (ESCC). show abnormally high expression ESCC tissues,...
Mutations modification enzymes including the tRNA N
Background Brain-derived neurotropic factor (BDNF) was originally described in the nervous system but has been shown to be expressed ovary tissues recently, acting as a paracrine/autocrine regulator required for developments of follicles and oocytes. Although it is generally accepted that chronic stress impairs female reproduction decreases expression BDNF limbic structures central system, which contributes mood disorder. However, not known whether affects oocytes developments, nor ovary....
Abstract Background Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approaches, 5-year event-free survival (EFS) patients advanced NBL remains below 30%, emphasizing urgent necessary novel therapeutic strategies. Studies have shown that epigenetic disorders play an essential role pathogenesis of NBL. However, function mechanism...
Abstract Objectives To investigate the inhibitory effects of STM2457, which is a novel METTL3 (m 6 A writer) inhibitor, both as monotherapy and in combination with anlotinib, treatment oral squamous cell carcinoma (OSCC) vitro vivo. Materials Methods The efficacy STM2457 or plus anlotinib was evaluated using two OSCC lines by CCK8, transwell, colony formation, would‐healing, sphere cycle, apoptosis assays, nude mice tumor xenograft techniques. molecular mechanism study carried out western...
Introduction With the growing number of Chinese postgraduate students, enhancing their creativity has become a pressing issue in higher education. This meta-analysis aimed to investigate relationship between supervisor support and using sample students explore potential moderating variables. Method The study incorporated 62 primary studies involving 51,640 graduate students. Results results revealed that was significantly positively associated with creativity. Meta-regression subgroup...
Melatonin has been shown to have neuroprotective effects. This study is aimed at observing the effects of copper deposition on cognitive function in a toxic milk (TX) mouse model Wilson disease (WD), and investigating mechanisms action Gandou Bushen Decoction (GDBSD) melatonin synthesis pineal WD mice. A total 30 homozygous TX mice were randomly assigned 3 groups (n = 10 each group), including group, GDBSD dimercaptosuccinic acid (DMSA) group. DL included normal control (NC) The structure...
Chronic psychosocial stress negatively affects ovarian function. Ovarian follicular development is regulated by both pituitary-derived gonadotropins and intraovarian regulatory factors. To date, the suppressive effects of chronic on ovary have been observed to be manifested mainly as an inhibition gonadotropin release. It not clear whether there are any other mechanisms involved in this process. Growth differentiation factor 9 (GDF9) important, oocyte-specific paracrine regulator required...
Ribosome RNA (rRNA) accounts for more than 80% of the cell's total RNA, while physiological functions rRNA modifications are poorly understood. Mutations 18S m6A methyltransferase METTL5 cause intellectual disability, microcephaly, and facial dysmorphisms in patients, however, little is known about underlying mechanisms. In this study, we identified protein complex revealed that mainly interacts with binding proteins ribosome proteins. Functionally, found Mettl5 knockout mESCs leads to...
There are considerable evidence of reproductive impairment in male organisms with Wilson disease (WD). The purpose this study was to observe spermatogenesis, mitochondrial damage, apoptosis, and the level oxidative stress testes model TX mice, effect mechanism glutathione on testicular spermatogenesis.Mice were divided into a normal control group (control group), mice (WD penicillamine-treated (penicillamine group) glutathione-treated (glutathione group). Testicular coefficient,...