A5101492796- RNA modifications and cancer
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Herpesvirus Infections and Treatments
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Biochemical and Structural Characterization
- RNA Research and Splicing
- Patient Satisfaction in Healthcare
- Genetic and phenotypic traits in livestock
- Ferroptosis and cancer prognosis
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Pneumonia and Respiratory Infections
- MicroRNA in disease regulation
- Antibiotic Use and Resistance
- Advanced biosensing and bioanalysis techniques
Nanchang University
2022
Shantou University
2020-2021
Affiliated Eye Hospital of Wenzhou Medical College
2021
Wenzhou Medical University
2021
Yue Bei People's Hospital
2020-2021
Fourth People's Hospital of Liaocheng
2020
Xian Yang Central Hospital
2020
Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery.
Micro-RNAs are involved in the occurrence and development of hepatocellular carcinoma (HCC) as potential therapeutic targets for HCC. In this study, we found that miR-27a-3p was highly expressed HCC, which associated with lower survival rates HCC patients. vivo vitro functional experiments confirmed over-expression or knock-down could significantly affect proliferation ability HCCLM3 Huh-7, two cell lines. Ubiquitin-specific protease 46 (USP46) key target gene via RNA-seq, quantitative...
This study aimed to investigate the effect of long-chain non-coding SOX21-AS1 on proliferation and migration breast cancer (BC) cells through PI3K/AKT signaling pathway.Eighty-eight BC adjacent tissues were collected, normal epithelial purchased. LncRNA expression in was detected by RT-PCR. miR-NC, si-SOX21-AS1, Sh-SOX21-AS1 transfected into cells. The pathway interfered with L740Y-P (activator pathway) LY294002 (inhibitor tested qRT-PCR, levels p-PI3K, p-AKT, N-cadherin, E-cadherin,...
Abstract Background Inappropriate prescribing of antibiotics for acute respiratory infections at the primary care level represents major source antibiotic misuse in healthcare, and is a driver antimicrobial resistance worldwide. In this study we will develop, pilot evaluate effectiveness comprehensive stewardship programme China’s hospitals to reduce inappropriate among all ages. Methods We use parallel-group, cluster-randomised, controlled, superiority trial with blinded outcome evaluation...
Autophagy is a process of engulfing one’s own cytoplasmic proteins or organelles and coating them into vesicles, fusing with lysosomes to form autophagic lysosomes, degrading the contents it encapsulates. Increasing studies have shown that autophagy disorders are closely related occurrence tumors. However, prognostic role genes in cervical cancer still unclear. In this study, we constructed risk signatures autophagy-related (ARGs) predict prognosis cancer. The expression profiles clinical...
Proteins play key roles in most biological processes, and protein dysfunction can cause various diseases. Over the past few decades, tremendous development has occurred therapeutic market due to high specificity, low side effects, risk of proteins. Currently, all drugs on are based extracellular targeting; more than 70% intracellular targets remain un-druggable. Efficient delivery cytosolic proteins is significance for drugs, advanced biotechnology molecular cell biology. Herein, we...