Chao Lu

ORCID: 0000-0003-4650-459X
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About
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Research Areas
  • RNA modifications and cancer
  • Orthopaedic implants and arthroplasty
  • Gallbladder and Bile Duct Disorders
  • Orthopedic Infections and Treatments
  • Total Knee Arthroplasty Outcomes
  • Pancreatic and Hepatic Oncology Research
  • Pancreatitis Pathology and Treatment
  • Cancer-related molecular mechanisms research
  • Congenital Heart Disease Studies
  • RNA Research and Splicing
  • Spinal Fractures and Fixation Techniques
  • Organ Transplantation Techniques and Outcomes
  • Liver physiology and pathology
  • Cancer-related gene regulation
  • Neonatal Respiratory Health Research
  • Epigenetics and DNA Methylation
  • Congenital Diaphragmatic Hernia Studies
  • Pelvic and Acetabular Injuries
  • Viral-associated cancers and disorders
  • Metal Forming Simulation Techniques
  • Congenital limb and hand anomalies
  • Surgical Simulation and Training
  • Abdominal Surgery and Complications
  • Acute Kidney Injury Research
  • Osteoarthritis Treatment and Mechanisms

Anhui University of Science and Technology
2022-2025

Hangzhou Medical College
2017-2025

Zhejiang Provincial People's Hospital
2017-2025

Anhui Medical University
2022-2024

Guangdong Provincial People's Hospital
2019-2023

Guangdong Academy of Medical Sciences
2019-2023

Guangdong Provincial Hospital of Traditional Chinese Medicine
2019-2023

Second Hospital of Anhui Medical University
2022

Wangjing Hospital of China Academy of Chinese Medical Sciences
2020-2021

Southern Medical University
2009-2020

Gallstone disease (GSD) is a prevalent gastrointestinal disorder, few studies have examined the combined effects of dietary and lifestyle factors on GSD. This study aims to investigate relationship between oxidative balance score (OBS) GSD, explores potential mediating role stress. Cross-sectional data from 6,196 participants in NHANES 2017–2020 were analyzed. OBS, encompassing 16 4 factors, was assessed alongside GSD prevalence. Weighted multivariate logistic regression, restricted cubic...

10.1186/s12937-025-01073-0 article EN cc-by-nc-nd Nutrition Journal 2025-01-10

Mitochondrial metabolism plays a pivotal role in various cellular processes and fibrosis. However, the mechanism underlying mitochondrial metabolic function liver fibrosis remains poorly understood. In this study, we determined whether mediates using cells, animal models, clinical samples to elucidate potential effects of We report that AlkB Homolog 5 (ALKBH5) decreases membrane (MMP) oxygen consumption rate (OCR), suppresses fission hepatic stellate cell (HSC) proliferation migration...

10.1016/j.phrs.2022.106608 article EN cc-by-nc-nd Pharmacological Research 2022-12-21

Abstract Objectives Increasing evidence have demonstrated the N6-methyladenosine (m 6 A) plays critical roles in osteoarthritis (OA) progression, but role of m A OA has not been completely illuminated. Herein, we investigated function and underlying mechanism demethylase fat mass obesity-associated protein ( FTO ) progression. Materials methods The expression was detected mice cartilage tissues lipopolysaccharide (LPS)-stimulated chondrocytes. Gain-of-function assays used to evaluate injury...

10.1186/s13075-023-03035-5 article EN cc-by Arthritis Research & Therapy 2023-04-01

Laparoscopic radical antegrade modular pancreatosplenectomy (LRAMPS) is a validated surgical treatment for patients with left-sided pancreatic ductal adenocarcinoma (PDAC). In addition, laparoscopic distal pancreatectomy (LDPS) has purported benefits. However, there limited analysis comparing the results between LRAMPS and LDPS. Thus, this study aims to compare short-term long-term outcomes of who underwent LDPS PDAC treatment. Patients that or from 2015 2021 were retrospectively identified....

10.3389/fsurg.2022.981591 article EN cc-by Frontiers in Surgery 2022-09-01

Background: Despite improvements in neonatal cardiac surgery and postoperative care, hospitalized death for infants with low birth weight remains high. Objective: This study sought to identify predictors of outcomes low-birth-weight undergoing congenital heart establish nomograms predict intensive-care unit (ICU) stay. Methods: From June 2009 2018, a retrospective review 114 (≤2.5 kg) was conducted at Guangdong Provincial People’s Hospital. Purely surgical ligation patent ductus arteriosus...

10.2147/tcrm.s206147 article EN cc-by-nc Therapeutics and Clinical Risk Management 2019-07-01

To construct a dynamic knee joint finite element model based on CT image data and verify the validity of model. provide simulation basic for biomechanical research by further analysis.The healthy male was selected. With help Mimics 19.0 Hypermesh 12.0 software, high established following steps, including geometric reconstruction, reverse engineering, meshing material characterization. The flexion generated determining boundary conditions torque loading, themodel confirmed. changes...

10.12200/j.issn.1003-0034.2020.05.018 article EN PubMed 2020-05-25

OBJECTIVE To study mechanism of improvement stress concentration on patellofemoral joint by stiletto needle releasing lateral patellar retinaculum guided the theory Jinshugu() and based finite element model knee joint. to elucidate biomechanical changing trajectory reducing pressure. METHODS CT data from a normal male (aged 29, heighted 171 cm, weighted 58 kg) was selected. Starting with construction three-dimensional using software, complete tendonand bone structures were established...

10.12200/j.issn.1003-0034.2021.02.006 article EN Zhongguo gushang 2021-02-01
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