Huanzi Zhong
A5100724501- Gut microbiota and health
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Microbial Community Ecology and Physiology
- Metabolomics and Mass Spectrometry Studies
- Pediatric health and respiratory diseases
- Colorectal Cancer Screening and Detection
- Bacteriophages and microbial interactions
- Food Security and Health in Diverse Populations
- Dietary Effects on Health
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Pancreatitis Pathology and Treatment
- Insect symbiosis and bacterial influences
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Probiotics and Fermented Foods
- Cystic Fibrosis Research Advances
BGI Group (China)
2015-2024
BGI Research
2023-2024
BGI Genomics
2024
University of Copenhagen
2017-2022
China National GeneBank
2016-2021
Ministry of Natural Resources
2010-2019
Fujian Institute of Oceanography
2010-2019
Tianjin Medical University Cancer Institute and Hospital
2017
Guangxi University for Nationalities
2016
Xiamen University
2010
The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of microbiome in relation diseases have not systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic disease (ACVD) 187 healthy controls. ACVD deviates status by increased abundance Enterobacteriaceae Streptococcus spp. and, functionally, potential for metabolism or transport several molecules important...
Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond vagina has been a matter of debate. Here we systematically sample microbiota within 110 women age, examine nature colonisation by 16S rRNA gene amplicon sequencing cultivation. We find cervical canal, uterus, fallopian tubes peritoneal fluid, differing from that vagina. The results reflect...
Abstract Background More extensive use of metagenomic shotgun sequencing in microbiome research relies on the development high-throughput, cost-effective sequencing. Here we present a comprehensive evaluation performance new high-throughput platform BGISEQ-500 for and compare its with that 2 Illumina platforms. Findings Using fecal samples from 20 healthy individuals, evaluated intra-platform reproducibility setup comprising 8 library replicates replicates. Cross-platform consistency was by...
Abstract Antidiabetic medication may modulate the gut microbiota and thereby alter plasma faecal bile acid (BA) composition, which improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases ratio between primary BAs secondary levels of unconjugated in treatment-naive type 2 diabetes (T2D) patients, beneficially affect metabolism. Acarbose relative abundances Lactobacillus Bifidobacterium depletes Bacteroides , changing abundance microbial genes involved...
Abstract Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering microbiota like oral intake of probiotics or berberine (BBR), bacteriostatic agent, merit metabolic homoeostasis. We hence conducted randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patients from 20 centres in China. Four-hundred-nine eligible participants were enroled, randomly assigned (1:1:1:1) and completed 12-week treatment either BBR-alone,...
A gluten-free diet (GFD) is the most commonly adopted special worldwide. It an effective treatment for coeliac disease and also often followed by individuals to alleviate gastrointestinal complaints. known there important link between gut microbiome, but it largely unknown how a switch GFD affects human microbiome. We studied changes in microbiomes of 21 healthy volunteers who four weeks. collected nine stool samples from each participant: one at baseline, during period, when they returned...
Background Insect midgut microbiota is important in host nutrition, development and immune response. Recent studies indicate possible links between insect gut resistance to biological chemical toxins. Studies of this phenomenon symbionts general have been hampered by difficulties culture-based approach. In the present study, DNA sequencing was used examine diamondback moth (DBM), Plutella xylostella (L.), a destructive pest that attacks cruciferous crops worldwide. Its ability develop many...
The gut microbiota evolves from birth and is in early life influenced by events such as mode, type of infant feeding, maternal antibiotics use. However, we still have a gap our understanding development older children, to what extent pre-school lifestyle modulate the composition microbiota, how this impinges on whole body metabolic regulation school-age children. Taking advantage KOALA Birth Cohort Study, long-term prospective cohort Netherlands with extensive collection high-quality host...
The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences the microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported groups different age ethnicity. However, confounding factors such as anti-diabetic medication hamper identification changes disease development.We used a combination in-depth metagenomics metaproteomics analyses faecal samples...
Abstract Background COVID-19 (coronavirus disease 2019) has caused a major epidemic worldwide; however, much is yet to be known about the epidemiology and evolution of virus partly due scarcity full-length SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) genomes reported. One reason that challenges underneath sequencing directly from clinical samples have not been completely tackled, i.e., with low viral load often results in insufficient reads for analyses. Methods We applied...
Since early February 2021, the causative agent of COVID-19, SARS-CoV-2, has infected over 104 million people with more than 2 deaths according to official reports. The key understanding biology and virus-host interactions SARS-CoV-2 requires knowledge mutation evolution this virus at both inter- intra-host levels. However, despite quite a few polymorphic sites identified among populations, variant spectra their evolutionary dynamics remain mostly unknown.Using high-throughput sequencing...
Herbivore specialists adapt to feed on a specific group of host plants by evolving various mechanisms respond plant defences. Insects also possess complex gut microbiotas but their potential role in adaptation is poorly understood. Our previous study the genome diamondback moth, Plutella xylostella, revealed an intrinsic capacity detoxify defence compounds, which important factor its success as pest. Here we expand that work with complete taxonomic and functional profile P. xylostella...
Abstract Background The rumen microbiota provides essential services to its host and, through role in ruminant production, contributes human nutrition and food security. A thorough knowledge of the genetic potential microbes will provide opportunities for improving sustainability production systems. availability gene reference catalogs from gut microbiomes has advanced understanding health disease humans other mammals. In this work, we established a catalog prokaryote genes bovine rumen....
Non-fasting lipidemia (nFL), mainly contributed by postprandial (PL), has recently been recognized as an important cardiovascular disease (CVD) risk fasting (FL). PL serves a common feature of dyslipidemia in Type 2 Diabetes (T2D), albeit effective therapies targeting on were limited. In this study, we aimed to evaluate whether the therapy combining probiotics (Prob) and berberine (BBR), proven antidiabetic hypolipidemic regimen via altering gut microbiome, could effectively reduce T2D...
Abstract The gut microbiome has been established as a key environmental factor to health. Genetic influences on the have reported, yet, doubts remain significance of genetic associations. Here, we provide shotgun data for whole genome and metagenome from Chinese cohort, identifying no <20% contribution microbiota. Using common variants-, rare copy number variations-based association analyses, identified abundant signals associated with especially in metabolic, neurological, immunological...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Coronavirus disease 2019 (COVID-19). However, the microbial composition tract and other infected tissues as well their possible pathogenic contributions to varying degrees severity in COVID-19 patients remain unclear. Between 27 January 26 February 2020, serial clinical specimens (sputum, nasal throat swab, anal swab feces) were collected from cohort hospitalized patients, including 8 mildly 15...