A5101688680- Salivary Gland Disorders and Functions
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Genetic Associations and Epidemiology
- Bone Metabolism and Diseases
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Vasculitis and related conditions
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- RNA Interference and Gene Delivery
- Connective tissue disorders research
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
Deyang Stomatological Hospital
2022-2024
Weatherford College
2021-2022
Fuyang City People's Hospital
2022
China National GeneBank
2017-2019
Translational Research Institute
2018
Queensland University of Technology
2018
Chongqing Medical University
2011
The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences the microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported groups different age ethnicity. However, confounding factors such as anti-diabetic medication hamper identification changes disease development.We used a combination in-depth metagenomics metaproteomics analyses faecal samples...
Generalised high bone mass (HBM), associated with features of a mild skeletal dysplasia, has prevalence 0.18% in UK DXA-scanned adult population. We hypothesized that the genetic component extreme HBM includes contributions from common variants small effect and rarer large effect, both enriched an phenotype cohort. performed genome-wide association study (GWAS) adults either or low BMD. Adults included individuals unexplained (n = 240) BMD Z-scores ≥+3.2, females Anglo-Australasian...
Abstract The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in East Asia population, associated with development of T2D remain to be characterized. Liquid chromatography coupled tandem mass spectrometry was applied detect lipidome fasting plasma 293 Chinese individuals, including 114 patients, 81 prediabetic subjects, 98 individuals normal glucose tolerance (NGT). Both qualitative quantitative...
The purpose was to identify transactivation DNA-binding protein–related genes in salivary gland injury primary Sjögren syndrome (pSS) southwest China. We downloaded the datasets of GSE7451, GSE23117, and GSE40611. In order screen candidate genes, 2 kinds machine learning algorithms were used. collected blood from 28 patients 20 controls verify expression using quantitative real-time polymerase chain reaction. receiver operating characteristic curve used evaluate diagnostic efficiency....
Primary Sjögren's syndrome (pSS) is known as autoimmune disease characterized by damage to endocrine glands, such the salivary and lacrimal glands. This study aimed identify potential biomarkers for pSS using integrated bioinformatics analysis explore relationship between differentially expressed genes (DEGs) immune infiltration. Three datasets (GSE7451, GSE23117, GSE40611) from gene expression omnibus database were integrated. All processed in R (version 4.0.3). A total of 16 cells 13...
This study aimed to identify copper-induced death genes in primary Sjögren's syndrome (pSS) and explore immune infiltration, risk drug prediction models for salivary glands (SGs) damage. The 3 datasets, including GSE40611, GSE23117, GSE7451 from the Gene Expression Omnibus database were downloaded. datasets processed using affy R (version 4.0.3). In cells, strongly expressed "activated" dendritic cells (aDCs), macrophages regulatory T (Treg). functions, major histocompatibility complex (MHC)...
Abstract Background The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences the microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported groups different age ethnicity. However, confounding factors such as anti-diabetic medication hamper identification changes disease development. Method We used a combination in-depth metagenomics metaproteomics...
The aim of this study was to retrospectively investigate the clinical significance anti-rods and rings (anti-RR) antibodies in nonhepatitis virus infection patients from Southwest China.Anti-RR were determined by indirect immunofluorescence assay a group 19,935 individuals with antinuclear test January 2017 December 2019. laboratory data collected. Finally, 66 samples anti-RR (0.33%) detected.In Wilcoxon rank sum test, gamma glutamyl transferase (Z = -3.364, P .001), alpha-l-fucosidase (AFU)...
Rheumatoid arthritis (RA) is a disease complicated with inflammatory synovitis, which seriously affects the life quality of patients. Early diagnosis important for prognosis RA. Here, we aimed to develop and assess model early RA in southwest China. A nomogram including 44 patients an was developed. Variables were filtered by least absolute contraction selection operator multiple logistic regression. The efficiency clinical application range evaluated. This showed that rheumatoid factor,...
Abstract Background: Primary Sojgren's syndrome (pSS) is known as autoimmune disease of endocrine system. This study aimed to identify potential biomarkers for pSS using integrated bioinformatics analysis and explore the relationship between differentially expressed genes (DEGs) immune infiltration. Methods: Three datasets (GSE7451, GSE23117 GSE40611) from Gene Expression Omnibus (GEO) database were integrated. All processed by affy in R (version 4.0.3). Results: A total 16 cells 13...