A5043097129- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Cystic Fibrosis Research Advances
- Energy, Environment, Economic Growth
- Respiratory viral infections research
- Helicobacter pylori-related gastroenterology studies
- Environmental Impact and Sustainability
- Traditional Chinese Medicine Analysis
- Colorectal Cancer Screening and Detection
- Long-Term Effects of COVID-19
- Energy, Environment, and Transportation Policies
- Optical Wireless Communication Technologies
- Cancer Mechanisms and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Endoplasmic Reticulum Stress and Disease
- Efficiency Analysis Using DEA
First Affiliated Hospital of Henan University
2023-2024
BGI Group (China)
2017-2024
BGI Research
2023-2024
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2024
University of Science and Technology Beijing
2019-2022
Xi’an University of Posts and Telecommunications
2021
University of Chinese Academy of Sciences
2017-2020
China National GeneBank
2017-2019
The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences the microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported groups different age ethnicity. However, confounding factors such as anti-diabetic medication hamper identification changes disease development.We used a combination in-depth metagenomics metaproteomics analyses faecal samples...
Abstract Background The rumen microbiota provides essential services to its host and, through role in ruminant production, contributes human nutrition and food security. A thorough knowledge of the genetic potential microbes will provide opportunities for improving sustainability production systems. availability gene reference catalogs from gut microbiomes has advanced understanding health disease humans other mammals. In this work, we established a catalog prokaryote genes bovine rumen....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Coronavirus disease 2019 (COVID-19). However, the microbial composition tract and other infected tissues as well their possible pathogenic contributions to varying degrees severity in COVID-19 patients remain unclear. Between 27 January 26 February 2020, serial clinical specimens (sputum, nasal throat swab, anal swab feces) were collected from cohort hospitalized patients, including 8 mildly 15...
The oral cavity of each person is home to hundreds bacterial species. While taxa for diseases have been studied using culture-based characterization as well amplicon sequencing, metagenomic and genomic information remains scarce compared the fecal microbiome. Here, shotgun data 3346 samples together with 808 published samples, we obtain 56,213 metagenome-assembled genomes (MAGs), more than 64% 3589 species-level genome bins (SGBs) contain no publicly available genomes. resulting collection...
Abstract Background Shotgun metagenomic sequencing has improved our understanding of the human gut microbiota. Various DNA extraction methods have been compared to find protocols that robustly and most accurately reflect original microbial community structures. However, these recommendations can be further refined by considering time cost demands in dealing with samples from very large cohorts. Additionally, fungal performance so far little investigated. Results We 6 protocols, MagPure Fast...
Abstract The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in East Asia population, associated with development of T2D remain to be characterized. Liquid chromatography coupled tandem mass spectrometry was applied detect lipidome fasting plasma 293 Chinese individuals, including 114 patients, 81 prediabetic subjects, 98 individuals normal glucose tolerance (NGT). Both qualitative quantitative...
Abstract Context Cushing syndrome (CS) is a severe endocrine disease characterized by excessive secretion of cortisol with multiple metabolic disorders. While gut microbial dysbiosis plays vital role in disorders, the microbiota CS remains unclear. Objective The objective this work to examine alteration patients CS. Methods We performed shotgun metagenomic sequencing fecal samples from 78 and healthy controls matched for age body mass index. Furthermore, we verify degradation capacity...
Abstract Aims/hypothesis The use of oral glucose-lowering drugs, particularly those designed to target the gut ecosystem, is often observed in association with altered microbial composition or functional capacity individuals type 2 diabetes. microbiota, turn, plays crucial roles modulation drug efficacy. We aimed assess impacts acarbose and vildagliptin on human microbiota relationships between pre-treatment therapeutic responses. Methods This was a randomised, open-labelled, two-arm trial...
The administration of oral antidiabetic drugs (OADs) to patients with type 2 diabetes elicits distinct and shared changes in the gut microbiota, acarbose berberine exhibiting greater impacts on microbiota than metformin, vildagliptin, glipizide. baseline strongly associates treatment responses OADs. Type (T2D) is a chronic metabolic disorder characterized by hyperglycemia increased insulin resistance, closely associated microbial dysbiosis [1]. Oral (OADs), such as sulfonylureas,...
DATA REPORT article Front. Cell Dev. Biol., 17 May 2022Sec. Stem Research https://doi.org/10.3389/fcell.2022.878346
Summary Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Coronavirus disease 2019 (COVID-19). However, microbial composition the tract and other infected tissues, as well their possible pathogenic contributions to varying degrees severity in COVID-19 patients remain unclear. Method Between January 27 February 26, 2020, serial clinical specimens (sputum, nasal throat swab, anal swab feces) were collected from cohort hospitalized patients,...
In a high-power underwater wireless optical communication (UWOC) system, the bandwidth limitations of sources and high-sensitivity detectors multipath effect seawater channels can cause intersymbol interference, which seriously affects performance UWOC system. Based on attenuation characteristics time-domain broadening signals, dual-mode adaptive switching blind equalization algorithm is proposed; it combines variable step size constant-to-mode fractional spaced equalizer (FSE) decision...
Drawing on a perspective of technology heterogeneity, this study advances the analytical framework for evaluation environmental efficiency (EE) across diverse economies. To improve continuity and robustness estimation, we construct Hybrid Malmquist–Luenberger index under meta-frontier (MHML) technique to allow dynamic probe underlying sources inefficiency. Decomposition MHML into component factors change (EC), Best Practice Change (BPC) Technological Gap (TPC) allows an improved...
Abstract A decade of studies has established the importance gut microbiome in human health. In spite sex differences physiology, lifespan, and prevalence many age-associated diseases, age disparities microbiota have been little studied. Here we show age-related adult microbial composition functionality two community-based cohorts from Northern China Netherlands. Consistently, women harbour a more diverse stable community across broad ranges, whereas men exhibit variable strongly correlated...
Hepatocellular carcinoma (HCC) is one of the ten most common malignant tumors in world, and it a major problem world. Traditional Chinese medicine (TCM) has many advantages prevention treatment HCC, but its complicated mechanism action difficult to clarify, which limits research development. The continuous development bioinformation technology provides new methods opportunities for TCM. This study used modern network pharmacology bioinformatic explore possible molecular herbal compound...
Abstract Background The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences the microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported groups different age ethnicity. However, confounding factors such as anti-diabetic medication hamper identification changes disease development. Method We used a combination in-depth metagenomics metaproteomics...
Abstract Objective To screen cuproptosis-relatedlncRNAs and establish a prognostic model of cuproptosis-related lncRNAs in hepatocellular carcinoma (HCC). Methods Perl R languages were used to collate the HCC transcriptome clinical data downloaded from TCGA database. Cuproptosis-related obtained through co-expression analysis, total samples randomly divided into Train group Test group. Univariate Cox regression LASSO multivariate analysis analyze lncRNAs. The accuracy was verified by...