A5004173697- Gut microbiota and health
- Parasite Biology and Host Interactions
- Helminth infection and control
- Parasites and Host Interactions
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Congenital Anomalies and Fetal Surgery
- Urinary Tract Infections Management
- Molecular Biology Techniques and Applications
- Reproductive tract infections research
- Parasitic infections in humans and animals
- Malaria Research and Control
- Coleoptera: Cerambycidae studies
- Gout, Hyperuricemia, Uric Acid
- Environmental and Biological Research in Conflict Zones
- Colorectal Cancer Screening and Detection
- Venomous Animal Envenomation and Studies
- Plant Pathogens and Fungal Diseases
- Chemical synthesis and alkaloids
- Plant biochemistry and biosynthesis
- Coleoptera Taxonomy and Distribution
- Cholinesterase and Neurodegenerative Diseases
- Metabolomics and Mass Spectrometry Studies
China National GeneBank
2019-2024
BGI Group (China)
2019-2024
University of Copenhagen
2024
Abstract Background Shotgun metagenomic sequencing has improved our understanding of the human gut microbiota. Various DNA extraction methods have been compared to find protocols that robustly and most accurately reflect original microbial community structures. However, these recommendations can be further refined by considering time cost demands in dealing with samples from very large cohorts. Additionally, fungal performance so far little investigated. Results We 6 protocols, MagPure Fast...
Genome sequencing has been widely used in plant research to construct reference genomes and provide evolutionary insights. However, few species have had their whole genome sequenced, thus restraining the utility of these data. We collected 1,093 samples vascular growing Ruili Botanical Garden, located southwest China. Of these, we sequenced 761 voucher specimens stored Herbarium China National GeneBank.
More than a decade of gut microbiome studies have common goal improving human health. However, while most the disease focused on elderly or middle-aged, reference cohort for in young individuals has been lacking. It is also not clear what other omics data need to be measured better understand microbiome. Here, we present including 2183 adults with high-depth metagenomic shotgun sequencing fecal and data. In this multiomic cohort, observe number vitamins, hormones, amino acids, trace elements...
The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from cohort of 516 Chinese women reproductive age, as well cervical, fecal, salivary second 632 women. Factors such pregnancyhistory, delivery history, cesarean section, breastfeeding were all more important than menstrual cycle in shaping the microbiome, information would be necessary before trying to interpret differences between...
Background Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The in the human body release DNA to circulatory system, which can be biomarker for echinococcosis. Cell-free (cfDNA) widely used medical research and has been applied various clinical settings. As echinococcosis, several PCR-based tests had trialed detect cell-free plasma or serum, but sensitivity was about 20% 25%. Low of...
Abstract More than a decade of gut microbiome studies have common goal for human health. As most the disease sample elderly or middle-aged, reference cohort young individuals has been lacking. It is also not clear what other omics data need to be measured better understand microbiome. Here we present high-depth metagenomic shotgun sequencing fecal together with in 2,183 adults, and observe number vitamins, hormones, amino acids trace elements correlate cluster T cell receptors. Associations...
Gut microbiome influenced many aspects of host physiology and psychology. Vice versa, lifestyles factors such as exercise healthy diet are ways to shape the gut microbiota towards balance. We observed two distinct microbe groups characterized by physical fitness in a multi-omic cohort 2183 young subjects with metagenomics, national physique comprehensive test, lifestyle metabolome data. The panel bacterial taxa including Clostridium bolteae, Escherichia coli, Ruminococcus gnavus,...
Persistent infections of high-risk human papillomaviruses (HPVs) are the leading cause cervical cancers. We collected exfoliated cell samples from females in Changsha city, Hunan Province and obtained 338 viral genomes four major HPV types, including 16 (n = 82), 18 35), 52 121) 58 100). The lineage/sublineage distribution HPVs confirmed previous epidemiological reports, with predominant prevailing sublineage as A4 (50%), A1 (37%) A3 (13%) for HPV16, (83%) HPV18, B2 (86%) HPV52 (65%), (19%)...
The evolution of parasites is often directly affected by the host's environment. Studies on same in different hosts are great interest and highly relevant to our understanding divergence.Here we performed whole-genome sequencing Parascaris univalens from Equus (horses, zebras donkeys). Phylogenetic selection analyses were study divergence adaptability P. univalens.At genetic level, multiple lines evidence indicate that mainly separated into two clades (horse-derived zebra & donkey-derived)....
The evolution of parasites is often directly affected by the host’s environment or behavior. Studies on same in different hosts are extremely attractive and highly relevant to our understanding divergence speciation. Here we analyzed genetic variation Equus roundworm populations (horses, zebras donkeys), presented first molecular evidence roundworms (Parascaris univalens). At level, were mainly separated into two clades (Horse-derived Zebra & Donkey-derived). This began at 600-1500 years...
Most of the disease studies for gut microbiome have collected cases and control samples from elderly or middle-aged. Despite general interest in health, it is not known how microbial biomarkers metagenome-wide association (MWAS) would perform a cohort young individuals, who be largely free chronic diseases, as well medication. Here we analyze high-depth fecal metagenomic shotgun sequencing 2183 healthy adults with clinical parameters, diet, lifestyle, metabolite measurements. We provide...
Abstract The evolution of parasites is often directly affected by the host's environment or behavior. Studies on same in different hosts are extremely attractive and highly relevant to our understanding divergence speciation. Here we presented first molecular evidence Equus roundworms (horses, zebras donkeys). At genetic level, were mainly separated into two clades (Horse-derived Zebra & Donkey-derived). This began at 600–1500 years ago, which interestingly coincided with domestication...
Abstract Persistent infections of high-risk human papillomaviruses (HPVs) are the leading cause cervical cancers. We collected exfoliated cell samples from females in Changsha city, Hunan Province and obtained 358 viral genomes four major HPV types, including 16 (n=82), 18 (n=35), 52 (n=121) 58 (n=100). The lineage/sublineage distribution HPVs confirmed previous epidemiological reports, with predominant prevailing sublineage as A4 (50%), A1 (37%) A3 (13%) for HPV16, (83%) HPV18, B2 (86%)...
Abstract Background The evolution of parasites is often directly affected by the host's environment. Studies on same in different hosts are extremely attractive and highly relevant to our understanding divergence speciation. Methods Here we performed whole genome sequencing Parascaris univalens from Equus (horses, zebras donkeys). Phylogenetic selection analysis was study adaptability P. . Results At genetic level, multiple lines evidence support that were mainly separated into two clades...