A5100413990- Reproductive tract infections research
- Gut microbiota and health
- Urinary Tract Infections Management
- Microbial infections and disease research
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Syphilis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Blood groups and transfusion
- Inflammatory Bowel Disease
- Antibiotic Use and Resistance
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Pelvic floor disorders treatments
- HIV, Drug Use, Sexual Risk
- Tuberculosis Research and Epidemiology
Dezhou University
2023
Qilu Hospital of Shandong University
2023
Zhejiang Chinese Medical University
2023
Foshan University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Massachusetts Institute of Technology
2021
BGI Group (China)
2019-2021
Peking University First Hospital
2019
Peking University
2019
Sixth Affiliated Hospital of Sun Yat-sen University
2017
Abstract The inflammatory intestinal disorder Crohn's disease (CD) has become a health challenge worldwide. gut microbiota closely interacts with the host immune system, but its functional impact in CD is unclear. Except for studies on small number of patients, analyses have used 16S rDNA amplicon sequencing. Here we employed metagenomic shotgun sequencing to provide detailed characterization compositional and features microbiota, comprising also unannotated bacteria, investigated modulation...
Vulvovaginal candidiasis (VVC) can alter the vaginal microbiome composition and structure, this may be correlated with its variable treatment efficacy. Integrated analysis of mycobiome bacteriome in VVC could facilitate accurate diagnosis infected patients further decipher characterized different types VVC. Our determined two common VVC, which were clustered into community state (CSTs) featured by Candida glabrata (CST I) albicans II). Subsequently, we compared CSTs other reproductive tract...
The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from cohort of 516 Chinese women reproductive age, as well cervical, fecal, salivary second 632 women. Factors such pregnancyhistory, delivery history, cesarean section, breastfeeding were all more important than menstrual cycle in shaping the microbiome, information would be necessary before trying to interpret differences between...
Healthcare associated infection (HAI) is known to increase the economic burden of patients while medical cost due MDRO HAI even higher. Three hundred eighty-one multidrug resistance organisms (MDROs) healthcare case-patients and three matched control-patients were identified between January December in 2015. The average total hospitalization case group was $6127.65 that control $2274.02. difference statistically significant (t = 21.07; P < 0.01). attributable $3853.63. direct costs...
Bovine respiratory disease (BRD), one of the most common and infectious diseases in beef industry, is associated with microbiome stressors transportation. The impacts bovine microbiota on health across different geographic locations sampling niches are poorly understood, resulting difficult identification BRD causes. In this study, we explored effects geography its function by re-analyzing published metagenomic datasets estimated main opportunistic pathogens that changed after results showed...
The gut microbiome has been the center of attention for human commensal studies. vaginal is also densely populated with bacteria, viruses and fungi, presence microorganisms beyond cervix increasingly reported in non-infectious conditions 1–3 . Due to over 90% sequences female reproductive tract samples 3,4 , metagenomic information very limited. 16S rRNA gene amplicon sequencing studies have identified community types microbiota, observed its dynamic changes due menstrual cycles sexual...
Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials new antibiotics compared other sites infection. However, accessibility oropharynx to topical therapeutics provides an opportunity intervention. Local...