A5055763559- Gut microbiota and health
- Oral microbiology and periodontitis research
- Reproductive tract infections research
- Genomics and Phylogenetic Studies
- Urinary Tract Infections Management
- Probiotics and Fermented Foods
- Oral Health Pathology and Treatment
- Diet and metabolism studies
- Salivary Gland Disorders and Functions
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Diet, Metabolism, and Disease
- Food Security and Health in Diverse Populations
- Metabolomics and Mass Spectrometry Studies
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Rheumatoid Arthritis Research and Therapies
- Pelvic floor disorders treatments
- Birth, Development, and Health
- HIV/AIDS oral health manifestations
- Mycobacterium research and diagnosis
- Microbial Community Ecology and Physiology
- Cervical Cancer and HPV Research
Chongqing Emergency Medical Center
2024
Chongqing University
2024
Chinese University of Hong Kong
2024
Hong Kong Jockey Club
2024
BGI Group (China)
2018-2023
Qingdao University
2020
Qingdao Municipal Hospital
2020
China National GeneBank
2018
Abstract Evaluating metagenomic software is key for optimizing metagenome interpretation and focus of the Initiative Critical Assessment Metagenome Interpretation (CAMI). The CAMI II challenge engaged community to assess methods on realistic complex datasets with long- short-read sequences, created computationally from around 1,700 new known genomes, as well 600 plasmids viruses. Here we analyze 5,002 results by 76 program versions. Substantial improvements were seen in assembly, some due...
Early treatment is key for optimizing the therapeutic success of drugs, and current initiating that blocks progression bone destruction during pre-arthritic stages remains unsatisfactory. The microbial disorder in rheumatoid arthritis (RA) patients significantly reversed with effective treatment. Modulating aberrant gut microbiomes into a healthy state potential approach preventing damage. By using metagenomic shotgun sequencing metagenome-wide association study, we assessed effect...
Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the is regarded as highly dynamic. Here, we report significant human genomic associations with metagenome from more than 1915 individuals, for both tongue dorsum ( n = 2017) saliva 1915). We identified five genetic loci associated at study-wide significance p < 3.16 × 10 −11 ). Four were well...
The oral cavity of each person is home to hundreds bacterial species. While taxa for diseases have been studied using culture-based characterization as well amplicon sequencing, metagenomic and genomic information remains scarce compared the fecal microbiome. Here, shotgun data 3346 samples together with 808 published samples, we obtain 56,213 metagenome-assembled genomes (MAGs), more than 64% 3589 species-level genome bins (SGBs) contain no publicly available genomes. resulting collection...
Abstract Background Laboratory rats such as the Sprague-Dawley (SD) are an important model for biomedical studies in relation to human physiological or pathogenic processes. Here we report first catalog of microbial genes fecal samples from rats. Findings The was established using 98 49 SD rats, divided 7 experimental groups, and collected at different time points 30 days apart. gene comprises 5,130,167 non-redundant with average length 750 bp, among which 64.6% 26.7% were annotated phylum...
The oral microbiome has been implicated in a growing number of diseases; however, determinants the and their roles remain elusive. Here, we investigated (saliva tongue dorsum) metagenome, whole genome, other omics data total 4,478 individuals demonstrated that composition its major contributing host factors significantly differed between sexes. We thus conducted sex-stratified metagenome-genome-wide-association study (M-GWAS) identified 11 differential genetic associations with...
Abstract Compelling evidence supports a link between early‐life gut microbiota and the metabolic outcomes in later life. Using an antibiotic exposure model BALB/c mice, we investigated life‐course impact of prenatal and/or postnatal exposures on microbiome offspring development dysfunction‐associated steatotic liver disease (MASLD). Compared to alone, more profoundly affected succession, which led aggravated endotoxemia dysfunctions. This was primarily resulted from overblooming...
The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from cohort of 516 Chinese women reproductive age, as well cervical, fecal, salivary second 632 women. Factors such pregnancyhistory, delivery history, cesarean section, breastfeeding were all more important than menstrual cycle in shaping the microbiome, information would be necessary before trying to interpret differences between...
By a survey of metagenome-wide association studies (MWAS), we found robust depletion Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection bacteria isolated from healthy Chinese individuals, selected B. R. intestinalis, longum, bacterium related to F. tested the effects these Apoe/- atherosclerosis mouse model. We show that administration three bacterial species...
Meningoencephalitis, an infectious disease affecting the nervous system, is primarily caused by a variety of pathogens. Non-tuberculous mycobacteria (NTM) have emerged as leading causative agent infections worldwide, but central system resulting from NTM are infrequent in individuals with functioning immune systems. This case report highlights diagnosis and treatment 26-year-old female patient who developed headaches 2 months post double eyelid surgery was subsequently diagnosed...
ABSTRACT The oral cavity of each person is home for hundreds bacterial species. While taxa diseases have been well studied using culture-based as amplicon sequencing methods, metagenomic and genomic information remain scarce compared to the fecal microbiome. Here we provide shotgun data 3346 metagenomics samples, together with 808 published assemble 56,213 metagenome-assembled genomes (MAGs). 64% 3,589 species-level genome bins contained no publicly available genomes, others only a handful....
Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in a number body sites. Challenged by eating, drinking and dental hygiene on daily basis, the is regarded as highly dynamic. Here, we report significant human genomic associations with metagenome from more than 1,915 individuals, for both tongue dorsum saliva. We identified five genetic loci associated at study-wide significance ( p < 3.16 × 10 −11 ). Four were well replicated an...