A5007390110- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Electrocatalysts for Energy Conversion
- Probiotics and Fermented Foods
- Fuel Cells and Related Materials
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Oral microbiology and periodontitis research
- Pregnancy and preeclampsia studies
- HER2/EGFR in Cancer Research
- Electrochemical Analysis and Applications
- Advanced battery technologies research
- Spectroscopy Techniques in Biomedical and Chemical Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Photoacoustic and Ultrasonic Imaging
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Nanoplatforms for cancer theranostics
- Diet and metabolism studies
- Ovarian cancer diagnosis and treatment
University of Hong Kong
2024-2025
University of Chinese Academy of Sciences
2020-2025
Fujian Institute of Research on the Structure of Matter
2025
Chinese Academy of Sciences
2025
Fuzhou University
2025
Chinese University of Hong Kong
2025
South China University of Technology
2020-2024
Avera Health
2015-2024
Binzhou University
2022-2024
Binzhou Medical University
2022-2024
Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the is regarded as highly dynamic. Here, we report significant human genomic associations with metagenome from more than 1915 individuals, for both tongue dorsum ( n = 2017) saliva 1915). We identified five genetic loci associated at study-wide significance p < 3.16 × 10 −11 ). Four were well...
Exploiting a pure culture strategy to investigate the composition of human gut microbiota, two novel anaerobes, designated strains AF52-21T and CM04-06T, were isolated from faeces healthy Chinese donors characterized using polyphasic approach. The observed be gram-negative, non-motile, rod-shaped. Both grew optimally at 37 °C pH 7.0. Phylogenetic analysis based on 16S rRNA gene sequences revealed that clustered with species genus Faecalibacterium most closely related prausnitzii ATCC 27768T...
Electrochemical reduction of oxygen plays a critical role in emerging electrochemical energy technologies. Multiple electron transfer processes, involving adsorption and activation O2 generation protons from water molecules, cause the sluggish kinetics reaction (ORR). Herein, double-active-site catalyst Fe3 C nanoparticles coupled to paulownia wood-derived N-doped carbon (Fe3 C@NPW) is fabricated via an active-site-uniting strategy. One site on contributes activating while another...
Culture-independent metagenomic studies have revolutionized our understanding of the gut microbiota. However, lack full genomes from cultured species is still a limitation for in-depth Here we present substantially expanded version Cultivated Genome Reference (CGR), termed CGR2, providing 3324 high-quality draft isolates selected large-scale cultivation bacterial fecal samples healthy Chinese individuals. The CGR2 classifies 527 (179 previously unidentified species) 8 phyla, and uncovers...
Abstract Utilizing supported single atoms as catalysts presents an opportunity to reduce the usage of critical raw materials such platinum, which are essential for electrochemical reactions hydrogen oxidation reaction (HOR). Herein, we describe synthesis a Pt electrocatalyst inside single‐walled carbon nanotubes (SWCNTs) via redox reaction. Characterizations electron microscopy, X‐ray photoelectron and absorption spectroscopy show single‐atom nature Pt. The behavior sample oxygen was...
Na + /K -ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three out and two K into cells. Additionally, participates Ca 2+ -signaling transduction neurotransmitter release coordinating ion concentration gradient membrane. works synergistically with multiple channels membrane to form dynamic network homeostatic regulation affects cellular communication regulating chemical signals balance among...
Raman spectroscopy is a powerful non-destructive technique for qualitatively and quantitatively characterizing materials.However, noise often obscures interesting peaks due to the inherently weak signal, especially in biological samples.In this study, we develop method based on spectral reconstruction recover spectra with low signalto-noise ratio (SNR).The synthesis of narrow-band measurements from low-SNR eliminates effect by integrating signal along wavenumber dimension, which followed...
Inconsistent findings linking placental histologic chorioamnionitis (HCA) and preterm delivery may result from variations in HCA definition, population studied, exclusion criteria. This analysis the 1998–2004 Pregnancy Outcomes Community Health Study (five Michigan communities) includes first 1,053 subcohort women (239 preterm, 814 term) with completed assessments. Multiple definitions were constructed by 1) varying polymorphonuclear leukocytes/high-powered field thresholds placenta...
Summary Infection of hepatitis B virus ( HBV ) occurs in ~10% infants ‐infected mothers with positive e antigen HB eAg) after immunoprophylaxis. We aimed to evaluate the safety and efficacy telbivudine used during late pregnancy for preventing mother‐to‐child transmission . conducted a multicenter prospective cohort study 5 hospitals from 2012 2014, which enrolled singleton pregnant women eAg. By their choice, were divided into therapy (telbivudine 600 mg/day, gestation 28‐32 weeks 3‐4...
The effect of doping Cr on the electrocatalytic activity Co2P supported carbon black (CrxCo2-xP/CB) for hydrogen evolution reaction (HER) and oxygen (OER) in alkaline solution was investigated. A beneficial improvement performance toward HER OER discovered. For at -200 mV overpotential, turnover frequency (TOF) increases almost 6-fold from 0.26 to 1.52 electron siteCo-1 s-1 when Co2P/CB has a small amount added form Cr0.2Co1.8P/CB. Similarly, we estimate an increase 0.205 0.585 1.6 V same...
While extensive literature shows Pt alloy catalysts are a more active substitute for pure at 0.9 V, high activity is also needed current densities if they to be adopted fuel cell application. We use newly developed electrochemical technique compare the performance of range with initial composition Pt4–xCox/C different particle sizes (∼0.65 V vs RHE) as well typical ∼0.9 RHE. Moving from 0.65 were found increase by up 80-fold Pt/C catalysts, this factor decreasing amount Co in PtCo increases....
Abstract The oral cavity harbors highly diverse communities of microorganisms. However, the number isolated species and high-quality genomes is limited. Here we present a Cultivated Oral Bacteria Genome Reference (COGR), comprising 1089 based on large-scale aerobic anaerobic cultivation human bacteria from dental plaques, tongue, saliva. COGR covers five phyla contains 195 species-level clusters which 95 include 315 representing with no taxonomic annotation. microbiota differs markedly...
In this study, oral supplementation of stachyose significantly improved HFD-induced MetS symptom, including overweight, hyperlipidemia, hepatic steatosis and system-wide inflammation. The subsequent analysis revealed that supplement enhanced the integrity intestinal epithelial barrier effectively reversed gut microbiota dysbiosis, as evidenced by improvements in microbial gene richness, composition, functional characteristics. abundance butyrate-producing strains, such Bacteroides faecis,...
Studies with circulating ribonucleic acid (RNA) not only provide new targets for cancer detection, but also open up the possibility of noninvasive gene expression profiling cancer. In this paper, we developed a surface-enhanced Raman scattering (SERS), platform detection and differentiation serum RNAs colorectal A novel three-dimensional (3-D), Ag nanofilm formed by dry MgSO4 aggregated silver nanoparticles, NP, as SERS-active substrate was presented to effectively enhance RNA signals. SERS...
ABSTRACT The Ebola virus (EBOV) surface glycoprotein (GP 1,2 ) mediates host cell attachment and fusion is the primary target for neutralizing antibodies. Expression of GP at high levels disrupts normal physiology, EBOV uses an RNA-editing mechanism to regulate expression gene. In this study, we demonstrate that impair production release virus-like particles (VLPs) as well infectivity -pseudotyped viruses. We further show effect mediated through two mechanisms. First, reduce synthesis other...
Abstract Background Nowadays, a positive HBV carrier status is common among pregnant women, especially in endemic areas (such as China), little known about the impact of maternal infection on risk adverse pregnancy outcomes. Pregnant women with often develop obstetric complications, such pregnancy-induced hypertension (PIH) syndrome, postpartum hemorrhage, and gestational diabetes mellitus (GDM), their infants exhibit neonatal complications. Methods This study undertook retrospective cohort...
The thin-film rotating disk electrode (TF-RDE) is a well-developed, conventional ex situ electrochemical method that limited by poor mass transport in the dissolved phase and hence can only measure kinetic response for Pt-based catalysts narrow overpotential range. Thus, applicability of TF-RDE results assessing how perform fuel cells has been questioned. To address this problem, we use floating (FE) technique, which facilitate high-mass to catalyst layer composed an ultralow loading (1-15...
Ovarian cancers rank first in both aggressiveness and dismal prognosis among gynecological neoplasms. The poor outcome is explained by the fact that most patients present with late-stage disease progress through line of treatment. neoplasms, especially epithelial ovarian cancers, are diagnosed at advanced/metastatic stages, often a high angiogenesis index, one hallmarks rapid progression as resistance to anti-angiogenic therapy develops. Despite therapy, metastatic aggressive cancer...
By a survey of metagenome-wide association studies (MWAS), we found robust depletion Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection bacteria isolated from healthy Chinese individuals, selected B. R. intestinalis, longum, bacterium related to F. tested the effects these Apoe/- atherosclerosis mouse model. We show that administration three bacterial species...
Abstract The Illumina HiSeq platform has been a commonly used option for bacterial genome sequencing. Now the BGI DNA nanoball (DNB) nanoarrays may provide an alternative sequencing of genomes. To explore impact platforms on assembly, quality assessment, sequence alignment, functional annotation, mutation detection, and metagenome mapping, we compared assemblies based cultured species using 2000 BGISEQ-500 platforms. In addition, simulated reads were to evaluate insert size assembly. Genome...