A5075573276- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Tuberculosis Research and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Antibiotic Resistance in Bacteria
- Dental Health and Care Utilization
- Oral Health Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Clostridium difficile and Clostridium perfringens research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Pelvic floor disorders treatments
- Bariatric Surgery and Outcomes
- Healthcare Systems and Public Health
- Immune cells in cancer
- Microscopic Colitis
- Fatty Acid Research and Health
- Cancer therapeutics and mechanisms
- China's Ethnic Minorities and Relations
Baker Heart and Diabetes Institute
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
BGI Group (China)
2012-2024
BGI Research
2024
Twelfth Guangzhou City People's Hospital
2023-2024
The University of Melbourne
2020-2023
Shanghai First People's Hospital
2018
University of Hong Kong
2017
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes.We performed metagenome-wide association studies on samples 74 patients with CRC and 54 controls China, validated results in 16 24 Denmark. We further biomarkers two published cohorts France Austria. Finally, we employed targeted quantitative PCR (qPCR) assays to diagnostic of selected an independent Chinese cohort 47 109 controls.Besides confirming known associations Fusobacterium nucleatum...
Abstract The role of bacteria other than Helicobacter pylori (HP) in the stomach remains elusive. We characterized gastric microbiota individuals with different histological stages carcinogenesis and after receiving HP eradication therapy. Endoscopic biopsies were obtained from subjects gastritis, intestinal metaplasia (IM), cancer (GC) negative controls. Gastric was by Illumina MiSeq platform targeting 16 S rDNA. Apart dominant H. , we observed Proteobacteria including Haemophilus,...
Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the is regarded as highly dynamic. Here, we report significant human genomic associations with metagenome from more than 1915 individuals, for both tongue dorsum ( n = 2017) saliva 1915). We identified five genetic loci associated at study-wide significance p < 3.16 × 10 −11 ). Four were well...
Although recent studies have revealed the association between human microbiome especially gut microbiota and longevity, their causality remains unclear. Here, we assess causal relationships (gut oral microbiota) by leveraging bidirectional two-sample Mendelian randomization (MR) analyses based on genome-wide (GWAS) summary statistics of from 4D-SZ cohort longevity CLHLS cohort. We found that some disease-protected such as Coriobacteriaceae Oxalobacter well probiotic Lactobacillus amylovorus...
Abstract The incidence of young-onset colorectal cancer (yCRC) has been increasing in recent decades, but little is known about the gut microbiome these patients. Most studies have focused on old-onset CRC (oCRC), and it remains unclear whether signatures derived from old patients are valid young To address this, we assembled largest yCRC metagenomes to date two independent cohorts found that had limited association with age across adulthood. Differential analysis revealed well-known...
Abstract Co-evolution between humans and the microbial communities colonizing them has resulted in an intimate assembly of thousands species mutualistically living on their body impacting multiple aspects host physiology health. Several studies examining whether human genetic variation can affect gut microbiota suggest a complex combination environmental factors. Here, we leverage single large-scale population-based cohort 5,959 genotyped individuals with matched shotgun metagenomes, dietary...
To analyze the changing trend of incidence and prevalence pneumoconiosis globally, provide scientific basis for formulation health policy.
Abstract Bioactive metabolites are central to numerous pathways and disease pathophysiology, yet many bioactive still uncharacterized. Here, we quantified using untargeted LC-MS plasma metabolomics in two large cohorts (combined N≈9,300) utilized genome-wide association analysis Mendelian randomization uncover genetic loci with roles metabolism prioritize metabolite features for more in-depth characterization. We identified 118 associated levels of 2,319 distinct which replicated across...
Weight loss and increased physical activity may promote beneficial modulation of the metabolome, but limited evidence exists about how very low-level weight affects metabolome in previously non-obese active individuals. Following a period (21.1 ± 3.1 weeks) leading to substantial fat mass 52% (−7.9 1.5 kg) low body (12.7 4.1%), liquid chromatography-mass spectrometry-based metabolic signature 24 young, healthy, normal female physique athletes was investigated. We observed uniform increases...
To investigate the surgical strategy for chronic pancreatitis complicated with suspected malignant lesions in pancreatic head and pancreatolithiasis distal pancreas.
<h3>Background</h3> To characterize the microbiome in early-onset colorectal cancer (aged <50, EOCRC) and late-onset CRC ≥50, LOCRC) patients. <h3>Methods</h3> 460 patients (167 were recruited Guangzhou, deep shotgun metagenomic sequencing was applied to stool saliva samples. <i>De novo</i> genome assembly, binning, inStrain, StrainPhlAn MetaPhlAn analyses performed. Stool metagenomes from a Fudan study (Yang <i>et al.</i>, 2021) consisting of 50 EOCRC, LOCRC 100 age-matched controls also...
Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in a number body sites. Challenged by eating, drinking and dental hygiene on daily basis, the is regarded as highly dynamic. Here, we report significant human genomic associations with metagenome from more than 1,915 individuals, for both tongue dorsum saliva. We identified five genetic loci associated at study-wide significance ( p < 3.16 × 10 −11 ). Four were well replicated an...
Abstract Although recent studies have revealed the association between human microbiome especially gut microbiota and longevity, their causality remains unclear. Here, we assess causal relationships (oral microbiota) by leveraging bidirectional two-sample Mendelian randomization (MR) analyses based on genome-wide (GWAS) summary statistics of oral from 4D-SZ cohort longevity CLHLS cohort. We found that some disease-protected such as Coriobacteriaceae Oxalobacter well probiotic Lactobacillus...