A5012053345- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- Immune cells in cancer
- Viral gastroenteritis research and epidemiology
- Chromosomal and Genetic Variations
- Molecular Biology Techniques and Applications
- Fungal and yeast genetics research
- Colorectal Cancer Screening and Detection
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Viral-associated cancers and disorders
- SARS-CoV-2 and COVID-19 Research
- Eating Disorders and Behaviors
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
Nottingham Trent University
2019-2024
Scotland's Rural College
2022-2023
University of the People
2023
Nankai University
2022
Qilu Normal University
2022
Chinese University of Hong Kong
2014-2019
Chinese University of Hong Kong, Shenzhen
2014-2019
University of Hong Kong
2015-2016
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes.We performed metagenome-wide association studies on samples 74 patients with CRC and 54 controls China, validated results in 16 24 Denmark. We further biomarkers two published cohorts France Austria. Finally, we employed targeted quantitative PCR (qPCR) assays to diagnostic of selected an independent Chinese cohort 47 109 controls.Besides confirming known associations Fusobacterium nucleatum...
Objective There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial markers diagnosing Design This study included 1012 subjects (274 CRC, 353 adenoma and 385 controls) from two independent Asian groups. Candidate were by metagenomics validated targeted quantitative PCR. Results Metagenomic analysis ‘ m3 ’ Lachnoclostridium sp., Fusobacterium nucleatum ( Fn ) Clostridium hathewayi Ch to be significantly enriched in...
Detecting microRNA (miRNA) in stool is a novel approach for colorectal cancer (CRC) screening. This study aimed to identify stool-based miRNA as noninvasive biomarkers detection of CRC and adenoma.A expression array covering 667 human miRNAs was performed on five pairs two advanced adenoma tissues. The most upregulated were validated 40 tissues, 16 424 samples, including 104 CRCs, 169 adenomas, 42 inflammatory bowel diseases (IBD), 109 healthy controls. levels followed-up after removal...
Abstract Somatic TP53 mutations and 17p deletions with genomic loss of occur in 37% to 46% acute myeloid leukemia (AML) adverse-risk cytogenetics correlate primary induction failure, high risk relapse, dismal prognosis. Herein, we aimed characterize the immune landscape TP53-mutated AML determine whether abnormalities identify a patient subgroup that may benefit from immunotherapy flotetuzumab, an investigational CD123 × CD3 bispecific dual-affinity retargeting antibody (DART) molecule. The...
The detection of microRNA (miRNA) dysregulation in stool is a novel approach for the diagnosis colorectal carcinoma (CRC). aim this study to investigate use miR-221 and miR-18a samples as non-invasive biomarkers CRC diagnosis. A miRNA expression array containing 667 miRNAs was performed identify tissues. We focused on miR-18a, two significantly upregulated which were subsequently verified 40 pairs tissues 595 (198 CRCs, 199 polyps 198 normal controls). array. levels also higher tumours...
This cross-sectional study aimed at measuring the correlation and association between serum levels of cortisol, inflammatory cytokines, depression to measure detection accuracy cortisol in samples. In total, 89 male participants were recruited into this from June 15, 2017, September 31, 2017. The Hamilton Depression Rating Scale, Beck Anxiety Inventory, Pittsburgh Sleep Quality Index used investigate mental health status participants. Serum concentrations cytokines determined. concentration,...
Background. Immune exhaustion and senescence are dominant dysfunctional states of effector T cells major hurdles for the success cancer immunotherapy. In current study, we characterized how acute myeloid leukemia (AML) promotes generation senescent-like CD8+ whether they have prognostic relevance.
Detection of microRNA (miRNA) aberrations in human faeces is a new approach for colorectal cancer (CRC) screening. The aim this study was to characterise miR-20a as non-invasive biomarker diagnosis CRC.miR-20a expression significantly higher the 40 CRC tumours compared their respective adjacent normal tissues (P = 0.0065). Levels were also faecal samples from patients < 0.0001). area under receiver operating characteristic (AUROC) curve 0.73, with sensitivity 55% and specificity 82%...
With the unprecedented rapid growth rate (up to 2.75 cm/day), velvet antler is an invaluable model for identification of potent factors and signaling networks extremely fast growing tissues, mainly cartilage. Antler center (AGC) locates in its tip consists five tissue layers: reserve mesenchyme (RM), precartilage (PC), transition zone (TZ), cartilage (CA) mineralized (MC). The aim this study was investigate transcription dynamics AGC using RNA-seq technology.Five layers were collected from...
In December 2019, the world awoke to a new betacoronavirus strain named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Betacoronavirus consists of A, B, C and D subgroups. Both SARS-CoV SARS-CoV-2 belong subgroup B. present study, we divided B into SARS1 SARS2 classes by six key insertions deletions (InDels) in genomes, identified recently detected strains RmYN02 as recombinant across classes, which has potential generate with similar risk SARS-CoV-2. By analyzing genomic...
Significance Although the three Akt isoforms share mechanisms of activation and exhibit overlaps in their downstream signaling pathways, significant differences are now being uncovered. Here, we show that among isoforms, Akt3 preferably phosphorylates p47 phox activates NADPH oxidase, resulting robust induction reactive oxygen species (ROS). Akt3-induced ROS activate DNA damage response upregulate p53 expression. Consequently, proliferation rate Akt3-expressing cells is reduced, an effect...
Decoding pancreatic ductal adenocarcinoma heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in progression.
Fecal microbiota transplantation (FMT) is highly effective in recurrent
To compare persistence and outcomes of non-vitamin K antagonist oral anticoagulants (NOACs) versus warfarin in Chinese patients with non-valvular atrial fibrillation (AF).Given the unpredictable response costliness NOACs, more research is needed to clarify which drug enjoys better outcomes, helping provide personalised care for patients.A prospective cohort study.Chinese taking NOACs or from March 2016-April 2018 were followed up by telephone outpatient visit at 3, 6 months half a year...
In the present study, we applied our 'precise annotation' to mitochondrial (mt) genomes of human, chimpanzee, rhesus macaque and mouse using 5' 3' end small RNAs. Our new annotations updated previous annotations. particular, led two important novel findings: (1) identification five Conserved Sequence Blocks (CSB1, CSB2, CSB3, LSP HSP) in control regions; (2) annotation Transcription Initiation Termination Sites. Based on these annotations, proposed a model mt transcription which can account...
Currently, methylotrophic yeasts (e.g., Pichia pastoris, Ogataea polymorpha, and Candida boindii) are subjects of intense genomics studies in basic research industrial applications. In the genus Ogataea, most is focused on three O. polymorpha strains-CBS4732, NCYC495, DL-1. However, relationship between CBS4732, DL-1 remains unclear, as genomic differences them have not be exactly determined without their high-quality complete genomes. As a nutritionally deficient mutant derived from strain...