A5101710942- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Adipose Tissue and Metabolism
- Cardiovascular Health and Disease Prevention
- Nitric Oxide and Endothelin Effects
- Congenital Heart Disease Studies
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- interferon and immune responses
- Cardiac electrophysiology and arrhythmias
- Vascular anomalies and interventions
- Heart Rate Variability and Autonomic Control
- Rheumatoid Arthritis Research and Therapies
- Birth, Development, and Health
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Systemic Lupus Erythematosus Research
- Blood Pressure and Hypertension Studies
- Mitochondrial Function and Pathology
- Viral Infections and Immunology Research
- Signaling Pathways in Disease
- Ultrasound Imaging and Elastography
Khanh Hoa General Hospital
2021-2024
Ho Chi Minh City Medicine and Pharmacy University
2022-2024
Houston Methodist
2009-2024
Laboratoire Traitement et Communication de l’Information
2024
Nottingham Trent University
2024
Baylor College of Medicine
2003-2023
Viet Duc Hospital
2021
Ark Medical Center
2021
Martin Luther King, Jr. Multi-Service Ambulatory Care Center
2014
Baylor University
2005
Abstract Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with enhanced inflammatory response. However, whether signaling causally linked to AF pathogenesis in obesity remains elusive. We recently demonstrated that the constitutive activation ‘NACHT, LRR, and PYD Domains-containing Protein 3’ (NLRP3) inflammasome promotes susceptibility. In this study, we hypothesized NLRP3 a key driver obesity-induced AF. Methods results Western blotting was...
Anatomic and functional changes after either a permanent left anterior descending coronary artery occlusion (PO) or 2 h of followed by reperfusion (OR) in C57BL/6 mice were examined compared with those sham-operated mice. Both interventions generated infarcts comprising 30% the ventricle (LV) measured at 24 equivalent suppression LV ejection velocity filling Doppler ultrasound 1 wk. Serial follow-up revealed that ventricular returned to levels controls OR group wk remained there; contrast,...
The mouse is a common model for transgenic manipulation, however, their small size has made hemodynamic study difficult. A noninvasive 10-MHz pulsed Doppler probe was used to measure aortic and mitral flow velocities in anesthetized, intact mice the effects of aging hypethyroidism (induced by thyroxine) one systolic diastolic cardiac function. In 10 hyperthyroid peak velocity (PAV, an index function) 34% higher than control (108 +/- 2 vs. 80 3 cm/s, P < 0.05). ratio early late filling...
Mice are used with increasing frequency as models of human cardiovascular diseases, but significant gaps exist in our knowledge vascular function the aging mouse. We determined aortic input impedance spectra, pulse wave velocity, and augmentation index adult (8-mo-old) old (29-mo-old) mice to determine whether arterial stiffening occurred age it does humans. Pressure blood velocity signals measured simultaneously from same location ascending aorta were spectra (0–10 harmonics). The first...
Decoding pancreatic ductal adenocarcinoma heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in progression.
Impaired cardiac diastolic function occurs with aging in many species and may be difficult to measure noninvasively. In humans, left atrial (LA) volume is a robust of chronic as the LA exposed increased ventricular filling pressures. We hypothesized that would useful indicator mice. Further, we asked whether pressures were propagated backwards affecting pulmonary arteries (PAs) right ventricle (RV). measured LA, PA, RV infundibulum dimensions echocardiography used mouse-specific Doppler...
We have developed a high-frequency, high-resolution Doppler spectrum analyzer (DSPW) and compared its performance against an adapted clinical Medasonics (MSA) zero-crossing interval histogram (ZCIH) used previously by us to evaluate cardiovascular physiology in mice. The aortic velocity (means +/- SE: 92.7 2.5 versus 82.2 1.8 cm/s) acceleration (8194 319 5178 191 cm/s2) determined the DSPW were significantly higher those MSA. Aortic ejection time was shorter (48.3 0.9 64.6 ms) isovolumic...
Viral-myocarditis is an important cause of heart failure for which no specific treatment available. We previously showed the neuropeptide substance P (SP) associated with pathogenesis murine myocarditis caused by encephalomyocarditis virus (EMCV). The current studies determined if pharmacological inhibition SP-signaling via its high affinity receptor, NK1R and downstream G-protein, Ras homolog gene family, member-A (RhoA), will be beneficial in viral-myocarditis. Aprepitant (1.2 mg/kg), a...
Microsatellite instability and allelic deletions of tumor suppressor genes have been observed frequently in tumors. Molecular pathogenesis the development dysplasia carcinoma ulcerative colitis is still unclear. In order to detect microsatellite alterations colitis, we analyzed loss heterozygosity (LOH) (MI) on chromosomes 3, 6, 7, 12, gene loci, including p53, APC, p16, chronically inflamed, non-dysplastic epithelium after microdissection. Twelve 13 (92%) cases showed LOH and/or MI at one...
The present methodology teaches the investigator how to measure and use LAV as a surrogate of chronic elevations in Left Ventricular diastolic pressure through echocardiography, well obtain measurements Aorta PA diameter mice. Mice older than 10 d age can be analyzed using technique. technique is composed 3 main steps: set-up, image acquisition, analysis. set-up step consists getting mouse anesthetized with 1% isoflurane, shaving it, taping it supine position heated EKG board where...
The maximum value of the first derivative invasively measured left ventricular (LV) pressure (+ dP/dtmax or P') is often used to quantify LV contractility, which in mice limited a single terminal study. Thus, determination P' mouse longitudinal/serial studies requires group at each desired time point resulting "pseudo" serial measurements. Alternatively, noninvasive surrogate for will allow repeated measurements on same mice, thereby minimizing physiological variability and requiring fewer...
Abstract We showed images of classic Blalock–Taussig–Thomas shunt in a 35-year-old male patient with tetralogy Fallot who underwent palliative surgery 1992. It is rare image echocardiography our modern life.
Abstract Cardiovascular dysfunctions are associated with advanced age. By 2050, the number of people older than 65 will triple. With this increased individuals, it becomes crucial to understand how different organs respond aging and if processes between men women. If so, then we need sex-specific approaches extend patients’ healthspan lifespan through effective management treatment strategies. We others have found distinct cellular responses in cardiac mice. In study, examined correlation...
A ductus arteriosus aneurysm is a rare congenital lesion with localized saccular or tubular dilation of the arteriosus. This usually appears in all ages. Some case reports suggest most common age diagnosis less than 2 months. We reported an asymptomatic neonates. Echocardiography at days revealed connected to pulmonary artery. Computed tomography angiogram showed thrombus end. It resolved spontaneously six months life without serious complications.
Takotsubo cardiomyopathy (TTC) is a reversible form of myocardial injury characterized by transient systolic and diastolic dysfunction secondary to regional left ventricle (LV) wall motion abnormalities. We present case rare variant TTC, termed reverse TTC (rTTC), involving basal hypokinesis with apical hyperkinesis accounting for less than 5% identified cases TTC. Our patient 49-year-old Hispanic female who presented evaluation dyspnea. She was diagnosed acute asthma exacerbation. The...
Abstract Many studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation response myocardial injury and improve outcomes. While the echocardiography standard parameters of left ventricular (LV) ejection fraction, fractional shortening, end-diastolic diameter, others, are used assess cardiac function, their dependency on loading conditions somewhat limit utility completely reflecting contractile function global...