A5079180838- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Gut microbiota and health
- Aquaculture disease management and microbiota
- Reproductive biology and impacts on aquatic species
- Diet and metabolism studies
- Nutritional Studies and Diet
- Fish Ecology and Management Studies
- Hormonal Regulation and Hypertension
- Pediatric health and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Peroxisome Proliferator-Activated Receptors
- Asthma and respiratory diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Odor and Emission Control Technologies
- Underground infrastructure and sustainability
- Metabolism, Diabetes, and Cancer
- Water Treatment and Disinfection
- Neonatal Respiratory Health Research
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Microbial infections and disease research
- Lipid metabolism and disorders
- Building materials and conservation
- Respiratory and Cough-Related Research
Statens Serum Institut
2018-2024
University of Copenhagen
2012-2023
Fish Physiology and Genomics Institute
2012-2018
University of Southern Denmark
2002-2017
BioInnovation Institute
2015
Institut de Génomique Fonctionnelle
2009
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes.We performed metagenome-wide association studies on samples 74 patients with CRC and 54 controls China, validated results in 16 24 Denmark. We further biomarkers two published cohorts France Austria. Finally, we employed targeted quantitative PCR (qPCR) assays to diagnostic of selected an independent Chinese cohort 47 109 controls.Besides confirming known associations Fusobacterium nucleatum...
The gut is inhabited by a densely populated ecosystem, the microbiota, that established at birth. However, succession which different bacteria are incorporated into microbiota still relatively unknown. Here, we analyze from 471 Swedish children followed birth to 5 years of age, collecting samples after 4 and 12 months 3 age as well their mothers using 16S rRNA gene profiling. We also compare an adult population. Genera follow colonization patterns during establishment where...
The intestinal microbiota is vital for shaping the local environment as well host immunity and metabolism. At same time, epidemiological experimental evidence suggest an important role parasitic worm infections in maintaining inflammatory regulatory balance of immune system. In line with this, prevalence persistent inversely correlated incidence immune-associated diseases, prompting use controlled parasite therapeutic purposes. Despite impact infection on microbiota, potential downstream...
Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets in fiber than subjects a low P/B ratio. Therefore, the aim of present study was examine potential differences dietary loss responses between participants and P/B. Eighty overweight were randomized (52 completed) 500 kcal/d energy deficit diet macronutrient composition 30 percentage (E%) fat, 52 E% carbohydrate 18 protein either (≈1500 mg calcium/day) or ( ≤...
BackgroundAsthmatic patients have higher microbiome diversity and an altered composition, with more Proteobacteria less Bacteroidetes compared healthy control subjects. Studies comparing airway inflammation the are sparse, especially in subjects not receiving anti-inflammatory treatment.ObjectiveWe sought to describe relationship between patterns of steroid-free asthma subjects.MethodsBronchoalveolar lavage fluid was collected from 23 nonsmoking 10 Bacterial DNA extracted subjected Illumina...
Abstract Understanding the evolutionary relationships between a host and its intestinal resident bacteria can transform how we understand adaptive phenotypic traits. The interplay hosts their inevitably affects environment and, thereby, living conditions of both microbiota. Thereby this co-existence likely influences fitness host. Whether leads to co-diversification in animals is largely unexplored, mainly due complexity microbial communities often low selection. We present gut metagenome...
Based on real-time RT-PCR, analysis of transcripts selected ion-regulatory proteins (Na(+), K(+)-ATPase alpha1a and alpha1b subunit, Na(+), K(+), 2Cl(-) cotransporter, cystic fibrosis transmembrane conductance regulator (CFTR), H(+)-ATPase B-subunit), the regulatory role cortisol associated receptor signaling pathway (glucocorticoid (GR) versus mineralocorticoid (MR)) was investigated in salmon gill. Using a gill organ culture technique, effect with without addition specific hormone...
SUMMARY The ability to reverse the net direction of gill ion transport in response a salinity change is critical for euryhaline teleosts and involves complex cellular molecular remodelling epithelium. present study aimed clarify localisation exact quantitative inter-relationship Na+,K+–ATPase α- andβ-subunit transcripts Atlantic salmon during change. combined expression level all α-isoforms increased by 100% after freshwater (FW) seawater (SW) transfer. α1aand α1b isoforms were both range...
The acyl-CoA-binding protein (ACBP) is a 10-kDa intracellular that specifically binds acyl-CoA esters with high affinity and structurally functionally conserved from yeast to mammals. In vitro studies indicate ACBP may regulate the availability of for various metabolic regulatory purposes. particularly abundant in cells level lipogenesis de novo fatty acid synthesis significantly induced during adipocyte differentiation. However, molecular mechanisms underlying regulation expression...
In euryhaline teleosts, permeability changes in gill epithelia are essential during acclimation to changed salinity. This study examined expression patterns of branchial tight junction proteins called claudins, which important determinants ion selectivity and general epithelia. We identified Atlantic salmon genes belonging the claudin family by screening expressed sequence tag libraries available at NCBI, classification was performed with aid maximum likelihood analysis. libraries, five...
The salmonid corticosteroid receptors (CRs), glucocorticoid 1 and 2 (GR1 GR2) the mineralocorticoid receptor (MR) share a high degree of homology with regard to structure, ligand- DNA response element-binding, cellular co-localization. Typically, these nuclear hormone homodimerize confer transcriptional activation target genes, but few studies using mammalian suggest some heterodimerization. We observed that trout MR confers several fold lower activity compared GRs. This made us question...
Female C57BL/6J mice were fed a regular low-fat diet or high-fat diets combined with either high low protein-to-sucrose ratios during their entire lifespan to examine the long-term effects on obesity development, gut microbiota, and survival. Intake of protein/sucrose ratio precipitated reduced survival relative diet. By contrast, intake attenuated lifelong weight gain adipose tissue expansion, was not significantly altered low-fat-fed mice. Our findings support notion that in response...
Cortisol and glucocorticoid receptors (GRs) play an important role in fish osmoregulation, whereas the involvement of mineralocorticoid receptor (MR) its putative ligand 11-deoxycorticosterone (DOC) is poorly investigated. In this study, we assessed implication DOC MR rainbow trout ( Oncorhynchus mykiss ) osmoregulation during hypo- hypersaline acclimation parallel with cortisol–GR system. A RIA for was developed to measure plasma levels, a MR-specific antibody localize protein gill,...
Scope The impact of dietary protein types on the gut microbiome is scarcely studied. aim present study therefore to examine effects lean‐seafood and non‐seafood proteins composition activity elucidate potential associations cardiovascular disease (CVD) risk factors. Methods A crossover intervention in which 20 healthy subjects consumed two diets that varied source was conducted. 1 H NMR spectroscopy 16S rDNA sequencing analyses were applied characterize fecal metabolites microbiota...
The role of cortisol as the only corticosteroid in fish osmoregulation has recently been challenged with discovery a mineralocorticoid-like hormone, 11-deoxycorticosterone (DOC), and necessitates new studies endocrinology fish. Using an vitro gill explant incubation approach, DOC-mediated regulation selected osmoregulatory target genes was investigated compared that two euryhaline teleosts, Mozambique tilapia ( Oreochromis mossambicus ) striped bass Morone saxatilis ). effects were tested...
The aim of this study was to examine the effect exercise training and dietary supplementation resveratrol on composition gut microbiota test hypothesis that can prevent high-fat diet (HFD)-induced changes in microbiota. Mice fed a HFD supplemented with (4 g/kg food) were protected against diet-induced obesity, while trained HFD-fed animals (running average 50 km/week) not. Dietary induced predominantly low-abundant bacteria, high-abundant bacteria as analyzed by ADONIS Weighted UniFrac...
During weight loss, dairy calcium is proposed to accelerate and fat-mass loss through increased fecal fat excretion. The primary objective was investigate if a high-dairy energy-restricted diet superior low in terms of changes body weight, composition, excretion over 24 weeks. Secondary objectives included energy excretion, resting expenditure, blood pressure, lipid metabolism, gut microbiota. In randomized, parallel-arm intervention study, 11 men 69 women (body mass index, 30.6 ± 0.3 kg/m2;...