A5045178606- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Gut microbiota and health
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Aquaculture disease management and microbiota
- Biochemical effects in animals
- Aquaculture Nutrition and Growth
- Nutrition, Genetics, and Disease
- Digestive system and related health
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Probiotics and Fermented Foods
Norwegian Institute of Marine Research
2018-2024
University of Copenhagen
2010-2017
Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity prostaglandin E2 (PGE2) are crucially involved in induction UCP1 expression inguinal white adipocytes, but not classic interscapular adipocytes. Cold-induced was repressed COX2 knockout (KO) mice by administration the COX inhibitor indomethacin wild-type mice. Indomethacin β-adrenergic...
Background Dietary interventions are critical in the prevention of metabolic diseases. Yet, effects fatty fish consumption on type 2 diabetes remain unclear. The aim this study was to investigate whether a diet containing farmed salmon prevents or contributes insulin resistance mice. Methodology/Principal Findings Adult male C57BL/6J mice were fed control (C), very high-fat without with Atlantic fillet (VHF and VHF/S, respectively), Western (WD WD/S, respectively). Other VHF reduced...
It is well known that the microbiota of high-fat (HF) diet-induced obese mice differs from lean mice, but to what extent, this difference reflects state or diet unclear. To dissociate changes in gut associated with high HF feeding those obesity, we took advantage different susceptibility C57BL/6JBomTac (BL6) and 129S6/SvEvTac (Sv129) obesity their responses inhibition cyclooxygenase (COX) activity, where COX activity BL6 prevents Sv129 accentuates obesity. Using HiSeq-based whole genome...
Studying host–microbiota interactions through the perspective of hologenome is gaining interest across all life sciences. Intestinal parasite infections are a huge burden on human and animal health; however, there few studies investigating role during infections. We address this gap in largest multi-omics fish microbiota study to date using natural cestode infection farmed Atlantic salmon. find clear association between infection, salmon lifetime growth, perturbation gut microbiota....
Female C57BL/6J mice were fed a regular low-fat diet or high-fat diets combined with either high low protein-to-sucrose ratios during their entire lifespan to examine the long-term effects on obesity development, gut microbiota, and survival. Intake of protein/sucrose ratio precipitated reduced survival relative diet. By contrast, intake attenuated lifelong weight gain adipose tissue expansion, was not significantly altered low-fat-fed mice. Our findings support notion that in response...
The notion that the obesogenic potential of high fat diets in rodents is attenuated when protein:carbohydrate ratio increased largely based on studies using casein or whey as protein source. We fed C57BL/6J mice fat-high casein, soy, cod, beef, chicken pork sources. Casein stood out most efficient preventing weight gain and accretion adipose mass. By contrast, chicken, to a lesser extent cod beef protein, had tissue mass relative mice. Decreasing with sources led accentuated accumulation....
Background Polyunsaturated n-3 fatty acids (n-3 PUFAs) are reported to protect against high fat diet-induced obesity and inflammation in adipose tissue. Here we aimed investigate if the amount of sucrose background diet influences ability PUFAs obesity, tissue glucose intolerance. Methodology/Principal Findings We fed C57BL/6J mice a protein- (casein) or sucrose-based supplemented with fish oil corn for 9 weeks. Irrespective acid source, diets rich became obese whereas protein remained lean....
Abstract Interactions between host and gut microbial communities are modulated by diets play pivotal roles in immunological homeostasis health. We show that exchanging the protein source a high fat, sugar, westernized diet from casein to whole-cell lysates of non-commensal bacterium Methylococcus capsulatus Bath is sufficient reverse western diet-induced changes microbiota state resembling lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) at thermoneutrality (T30 °C)....
Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes other obesity-related diseases. Here, we find adipose expression the small neutral amino acid transporter SLC7A10, also known as alanine-serine-cysteine transporter-1 (ASC-1), shows strong inverse correlates with visceral adiposity, resistance, adipocyte hypertrophy across multiple cohorts. Concordantly, loss Slc7a10 function in zebrafish...
Fish oil rich in n-3 polyunsaturated fatty acids is known to attenuate diet-induced obesity and adipose tissue inflammation rodents. Here we aimed investigate whether different carbohydrate sources modulated the antiobesity effects of fish oil. By feeding C57BL/6J mice isocaloric high-fat diets enriched with for 6 wk, show that increasing amounts sucrose dose-dependently increased energy efficiency white (WAT) mass. Mice receiving fructose had about 50% less WAT mass than fed a high diet...
Chronic low grade inflammation is closely linked to obesity-associated insulin resistance. To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and sensitivity, we fed obesity-prone male C57BL/6J mice high fat/high sucrose (HF/HS) diet or regular supplemented not with indomethacin (±INDO) for 7 weeks. Development obesity, resistance, glucose intolerance was monitored, effect on glucose-stimulated...
The tumor suppressor p53 (TRP53 in mice) is known for its involvement carcinogenesis, but work during recent years has underscored the importance of regulation whole body metabolism. A general notion that necessary efficient oxidative UCP1-dependent uncoupled respiration and increased oxidation glucose fatty acids brown or brown-like adipocytes, termed brite beige, relation to energy balance homeostasis been highlighted recently. classic interscapular adipose tissue central cold-induced...
Scope Omega‐6 ( n ‐6) PUFA‐rich diets are generally considered obesogenic in rodents. Here, we examined how long‐term intake of a high‐fat/high‐sucrose (HF/HS) diet based on safflower oil affected metabolism, inflammation, and gut microbiota composition. Methods results We fed male C57BL/6J mice HF/HS oil—rich ‐6 PUFAs—or low‐fat/low‐sucrose for 40 wk. Compared to the diet, safflower‐based only led moderate weight gain, while glucose intolerance developed at week 5 prior signs but concurrent...
Abstract Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion C20 fatty acids into various regulatory lipid mediators, cyclooxygenase activity has been implicated in browning white adipose tissues. We generated transgenic (TG) C57BL/6 mice expressing the Ptgs2 gene encoding cyclooxygenase-2 (COX-2) mature adipocytes. TG fed a high-fat diet displayed marginally lower weight gain with less hepatic steatosis slight improvement insulin sensitivity,...
BackgroundThe obesogenic potential of high-fat diets (HFD) in rodents is attenuated when the protein:carbohydrate ratio increased. However, it not known if intake an HFD irrespective and absence weight gain, affects glucose homeostasis gut microbiota.MethodsWe fed C57BL6/J mice 3 different HFDs with decreasing ratios for 8 weeks compared results to a LFD reference group. We analyzed microbiota composition by 16S rDNA amplicon sequencing intestinal gene expression real-time PCR. Whole body...
Antipsychotic drugs can negatively affect the metabolic status of patients, with olanzapine as one most potent drugs. While patients are often medicated for long time periods, experiments in rats typically run 1 to 12 weeks, showing olanzapine-related weight gain and increased plasma lipid levels, transcriptional upregulation lipogenic genes liver adipose tissue. It remains unknown whether will deteriorate time. To examine long-term effects, we administered intramuscular long-acting...
Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose (HF/HS) diet induce obesity then either maintained on HF/HS or shifted low-fat (LF) containing salmon entrecote. For each diet, half animals exercised voluntarily for 8 weeks. We determined body composition, glucose tolerance, insulin sensitivity hepatic triacylglycerol levels. The...
Low-fat diets and energy restriction are recommended to prevent obesity induce weight loss, but high-protein popular alternatives. However, the importance of protein source in prevention loss is unclear. The aim this study was investigate ability different animal sources or reverse by using lean obese C57BL/6J mice fed high-fat/high-protein low-fat with casein, cod pork as sources. Only casein-based diet completely prevented development when mice. In mice, ad libitum intake a modestly...
Alternative feed ingredients for farmed salmon are warranted due to increasing pressure on wild fish stocks. As locally blue mussels may represent an environmentally sustainable substitute with a lower carbon footprint, we aimed test the potential and safety of substituting meal mussel in Atlantic salmon. Salmon were fed diets which was partially replaced increments, accounting up 13.1 % ingredients. Fillets from subsequently used prepare obesity-promoting western 13-weeks mouse feeding...