A5043267458- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Bariatric Surgery and Outcomes
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Endoplasmic Reticulum Stress and Disease
- Sleep and Wakefulness Research
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
University of Bergen
2015-2025
Haukeland University Hospital
2016-2025
Instituto de Investigación Sanitaria de Santiago
2009-2023
Weatherford College
2023
Oslo University Hospital
2023
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017
Universidade de Santiago de Compostela
2009-2017
Centro de Investigación Biomédica en Red
2015-2017
Marqués de Valdecilla University Hospital
2017
Instituto de Investigación Marqués de Valdecilla
2017
GLP-1 receptor (GLP-1R) is widely located throughout the brain, but precise molecular mechanisms mediating actions of and its long-acting analogs on adipose tissue as well brain areas responsible for these interactions remain largely unknown. We found that central injection a clinically used GLP-1R agonist, liraglutide, in mice stimulates brown (BAT) thermogenesis adipocyte browning independent nutrient intake. The mechanism controlling hypothalamic ventromedial nucleus (VMH), activation...
Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous controlled studies in both humans and rodents have reported nicotine exerts marked anorectic action. The effects of on energy homeostasis been mostly pinpointed central nervous system, but molecular mechanisms controlling its action are still not fully understood. aim this study was investigate effect hypothalamic AMP-activated protein...
The canonical view about the effect of thyroid hormones (THs) on thermogenesis assumes that hypothalamus acts merely as a modulator sympathetic outflow brown adipose tissue (BAT). Recent data have challenged vision by demonstrating THs act ventromedial nucleus (VMH) to inhibit AMP-activated protein kinase (AMPK), which regulates thermogenic program in BAT, leading increased and weight loss. Current shown addition activation fat, browning white (WAT) might also be an important mechanism....
The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine clozapine. However, molecular mechanisms involved antipsychotic-induced hyperphagia remain unclear. Here, we investigate effect administration on regulation hypothalamic controlling food intake, namely neuropeptide expression AMP-activated protein kinase (AMPK)...
The chaperone GRP78/BiP (glucose-regulated protein 78 kDa/binding immunoglobulin protein) modulates folding in reply to cellular insults that lead endoplasmic reticulum (ER) stress. This study investigated the role of hypothalamic GRP78 on energy balance, with particular interest thermogenesis and browning white adipose tissue (WAT). For this purpose, we used diet-induced obese rats administered thapsigargin, by combining metabolic, histologic, physiologic, pharmacologic, thermographic,...
Abstract p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates cellular response stress. Deficiency or excess nutrients causes stress, we hypothesized that could be linked glucose maintenance. We show here upon starvation hepatic is stabilized by O -GlcNAcylation plays an essential role in physiological regulation homeostasis. More specifically, binds PCK1 promoter its transcriptional activation, thereby controlling production. Mice lacking...
There is limited long-term data comparing the outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) for severe obesity, both with respect to body weight, quality life (QOL) comorbidities. We aimed determine 7-year trajectories mass index (BMI), QOL, obesity-related comorbidities, biomarkers glucose lipid metabolism, early major complications after SG RYGB.Patients scheduled bariatric surgery at two Norwegian hospitals, preferentially performing either or RYGB, were included...
Nicotine, the main addictive component of tobacco, promotes body weight reduction in humans and rodents. Recent evidence has suggested that nicotine acts central nervous system to modulate energy balance. Specifically, modulates hypothalamic AMP-activated protein kinase decrease feeding increase brown adipose tissue thermogenesis through sympathetic system, leading loss. Of note, most this been obtained animal models fed with normal diet or low-fat (LFD). However, its effectiveness obese...
Compelling evidence has shown that, besides its putative effect on the regulation of gonadal axis, estradiol (E2) exerts a dichotomic hypothalamus to regulate food intake and energy expenditure. The anorectic E2 is mainly mediated by action arcuate nucleus (ARC), whereas effects brown adipose tissue (BAT) thermogenesis occur in ventromedial (VMH). Here, we demonstrate that central decreases hypothalamic ceramide levels endoplasmic reticulum (ER) stress. Pharmacological or genetic blockade...
Non-alcoholic fatty liver disease (NAFLD), and the progressive stage nonalcoholic steatohepatitis (NASH), is predominant cause of chronic globally. As part complex pathogenesis, natural killer (NK) cells have been implicated in development inflammation experimental murine models NASH. However, there a lack knowledge on how NK are affected humans with this disease. Here, we explored presence disease-specific changes within circulating tissue-resident cell populations, as well other major...
The etiology of schizophrenia is unknown, but neurodevelopmental disturbances, myelin- and oligodendrocyte abnormalities synaptic dysfunction have been suggested as pathophysiological factors in this severe psychiatric disorder. Cholesterol an essential component myelin has proved important for synapse formation. Recently, we demonstrated that the antipsychotic drugs clozapine haloperidol stimulate lipogenic gene expression cultured glioma cells through activation sterol regulatory...
Metabolic adverse effects such as weight gain and dyslipidaemia represent a major concern in treatment with several antipsychotic drugs, including olanzapine. It remains unclear whether metabolic side-effects fully depend on appetite-stimulating actions, or some dysmetabolic features induced by antipsychotics may arise through direct perturbation of pathways relevant peripheral tissues. Recent clinical preclinical studies indicate that could occur independently gain. Using rat model, we...
This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent prior weight gain. In the current study, we examined a single intraperitoneal injection clozapine or olanzapine induced metabolic adult outbred Sprague–Dawley rats. Serum lipid parameters were measured during time-course experiments up 48 h. Real-time quantitative PCR was used...