A5072108506- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Liver Diseases and Immunity
- Heat shock proteins research
- Musculoskeletal pain and rehabilitation
- Immunotherapy and Immune Responses
- Anesthesia and Pain Management
- Liver Disease Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Hepatitis C virus research
- Advanced MRI Techniques and Applications
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- Cerebrovascular and Carotid Artery Diseases
- Monoclonal and Polyclonal Antibodies Research
- thermodynamics and calorimetric analyses
- Viral Infections and Vectors
- Medical Imaging Techniques and Applications
- Myofascial pain diagnosis and treatment
- MRI in cancer diagnosis
Philipps University of Marburg
1996-2024
Karolinska University Hospital
2018-2023
Karolinska Institutet
2018-2023
Stockholm University
2013
University Children's Hospital Tübingen
2011
Essen University Hospital
2007
Klinikum Saarbrücken
2007
Vienna Biocenter
2006
University Hospital Leipzig
2005
Leipzig University
2004
The proper segregation of sister chromatids in mitosis depends on bipolar attachment all chromosomes to the mitotic spindle. We have identified small molecule Hesperadin as an inhibitor chromosome alignment and segregation. Our data imply that causes this phenotype by inhibiting function kinase Aurora B. Mammalian cells treated with enter anaphase presence numerous monooriented chromosomes, many which may both kinetochores attached one spindle pole (syntelic attachment). also arrested taxol...
Treatment with nucleos(t)ide analogues (NA) suppresses hepatitis B virus (HBV) DNA but rarely leads to functional cure of chronic (CHB). Following NA cessation, some e antigen (HBeAg)-negative CHB patients experience s (HBsAg) loss. Cellular immune responses, including natural killer (NK) cell explaining virological events following treatment cessation remain elusive. In a single-center prospective trial, 15 HBeAg-negative on long-term underwent structured and were studied longitudinally....
Non-alcoholic fatty liver disease (NAFLD), and the progressive stage nonalcoholic steatohepatitis (NASH), is predominant cause of chronic globally. As part complex pathogenesis, natural killer (NK) cells have been implicated in development inflammation experimental murine models NASH. However, there a lack knowledge on how NK are affected humans with this disease. Here, we explored presence disease-specific changes within circulating tissue-resident cell populations, as well other major...
Despite animal models showing that natural killer (NK) cells are important players in the early defense against many viral infections, NK cell response is poorly understood humans. Here we analyze phenotype, temporal dynamics, regulation and trafficking of a patient cohort with acute dengue virus infection. robustly activated proliferate during first week after symptom debut. Increased IL-18 levels plasma induced skin blisters DENV-infected patients, as well concomitant signaling downstream...
Bile ducts from patients with PSC are enriched in neutrophils and biliary-resident CD8 + T cells differ composition liver tissue.
Abstract Primary sclerosing cholangitis (PSC) is a severe chronic liver disease of the small and large bile ducts. The pathogenesis unknown but strong immune cell component has been suggested. Mucosal‐associated invariant T (MAIT) cells are abundant in human localize around Yet, role MAIT PSC remains unclear. Here, we performed detailed characterization circulation assessed their presence ducts patients as well non‐PSC controls. We observed dramatic reduction levels patients....
Abstract Background and Aims Cholangiocarcinoma (CCA) is a malignancy arising from biliary epithelial cells of intra‐ extrahepatic bile ducts with dismal prognosis few nonsurgical treatments available. Despite recent success in the immunotherapy‐based treatment many tumor types, this has not been successfully translated to CCA. Mucosal‐associated invariant T (MAIT) are cytotoxic innate‐like highly enriched human liver, where they located close proximity epithelium. Here, we aimed...
Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) after sensing viral/bacterial RNA or DNA by toll-like receptor (TLR) 7 TLR9, respectively. However, aberrant pDCs activation can cause adverse effects on the host and contributes to pathogenesis of IFN-related autoimmune diseases. Here, we show that heparin interacts with human pDCs-specific blood cell antigen 2 (BDCA-2) but not related lectins such as DCIR dectin-2. Importantly, BDCA-2–heparin interaction depends...
The menstrual cycle is regulated by a complex interplay between endometrial epithelial cells, endothelial immune and sex hormones. To communicate, cells secrete cytokines that have multiple diverse effects on recipient cells. Knowledge of how these interact in the uterus insufficient. Menstrual blood easily accessible provides source to study physiology. This aimed determine cytokine profile plasma investigate differences profiles peripheral plasma. Several previous studies indicate an...
We studied 210 unselected patients with acute myeloid leukaemia (AML) for MLL abnormalities. Twenty‐seven (13%) rearranged genes were identified by means of Southern blot analysis. An MLL–AF6 fusion transcript was detected in six a reverse transcriptase polymerase chain reaction (RT‐PCR) the translocation. Sequence analysis showed exon 7 as well 6 (two patients) or 5 (four to AF6 2. In only three could t(6;11) also be cytogenetic and/or fluorescence situ hybridization (FISH) The ‐positive...
There seems to be a correlation between early gut microbiota composition and postnatal immune development. Alteration in the microbial life has been associated with mediated diseases, such as autoimmunity allergy. We have previously observed associations presence of lactobacilli Staphylococcus (S.) aureus early-life microbiota, cytokine responses allergy development children. Consistent objective understand how bacteria modulate response intestinal epithelial cell (IEC) lines cells, we...
Background & Aims Chronic inflammation surrounding bile ducts contributes to the disease pathogenesis of most cholangiopathies. Poor efficacy immunosuppression in these conditions suggests biliary-specific pathological principles. Here we perform biliary niche specific functional interpretation a causal mutation (CD100 K849T) primary sclerosing cholangitis (PSC) understand related pathogenic mechanisms. Methods Biopsies explanted livers and endoscopy-guided sampling were used assess CD100...