A5103232492- Social and Educational Sciences
- Education, Healthcare and Sociology Research
- Research in Social Sciences
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Language, Metaphor, and Cognition
- Building Energy and Comfort Optimization
- Teacher Education and Leadership Studies
- Esophageal Cancer Research and Treatment
- Housing, Finance, and Neoliberalism
- Family Support in Illness
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- European and International Law Studies
- Immune cells in cancer
- Epilepsy research and treatment
- Climate Change and Health Impacts
- Language, Discourse, Communication Strategies
- Electoral Systems and Political Participation
Haukeland University Hospital
2019-2022
There is limited long-term data comparing the outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) for severe obesity, both with respect to body weight, quality life (QOL) comorbidities. We aimed determine 7-year trajectories mass index (BMI), QOL, obesity-related comorbidities, biomarkers glucose lipid metabolism, early major complications after SG RYGB.Patients scheduled bariatric surgery at two Norwegian hospitals, preferentially performing either or RYGB, were included...
Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes other obesity-related diseases. Here, we find adipose expression the small neutral amino acid transporter SLC7A10, also known as alanine-serine-cysteine transporter-1 (ASC-1), shows strong inverse correlates with visceral adiposity, resistance, adipocyte hypertrophy across multiple cohorts. Concordantly, loss Slc7a10 function in zebrafish...
Abstract Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a transcriptome dataset tissue, we identified strong correlations for 56 genes mRNA, including targets TGF-β/SMAD signaling. Among the candidates, homeobox transcription factor PRRX1 showed particularly striking co-expression , validated across several different cohorts,...
Abstract The objective of this study was to compare the biochemical changes related glucose tolerance and lipid metabolism in non-diabetic patients shortly after vertical sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). Non-diabetic women men with morbid obesity were studied day before six days SG (N = 15) RYGB 16). Patients completed an oral test (OGTT; 75 g glucose) at both visits. similarly improved fasting homeostasis surgery, reduced insulin concentrations. OGTT revealed...
A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition white tissue believed to contribute pathogenesis metabolic diseases, but detailed characterization pro- and anti-inflammatory macrophages (ATMs) human obesity how they are distributed visceral- subcutaneous depots lacking. In this study, we performed surface proteome screening ATMs both subcutaneous- (SAT) visceral (VAT) evaluated their...
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Elucidation of mechanisms that govern lipid storage, oxidative stress and insulin resistance may lead to improved therapeutic options for type 2 diabetes other obesity-related diseases. Here, we find adipose expression the small neutral amino acid transporter SLC7A10, also known as alanine-serine-cysteine 1 (ASC-1), shows strong inverse correlates with visceral adiposity, adipocyte hypertrophy across multiple cohorts. Concordantly, loss Slc7a10 function in zebrafish <i>in...