A5007449495- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Childhood Cancer Survivors' Quality of Life
- Protein Degradation and Inhibitors
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Bone and Joint Diseases
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Cancer survivorship and care
- Hemoglobinopathies and Related Disorders
- Protease and Inhibitor Mechanisms
TU Dresden
2015-2024
University Hospital Carl Gustav Carus
2014-2023
Medical University of Vienna
2023
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2012-2022
Klinik und Poliklinik für Augenheilkunde am Universitätsklinikum Carl Gustav Carus
2022
Erasmus MC Cancer Institute
2022
Sheba Medical Center
2022
Helios Kliniken
2021
Nationales Centrum für Tumorerkrankungen Dresden
2019
German Cancer Research Center
2013-2018
Owing to the more recent positive results with anti-CD33 immunotoxin gemtuzumab ozogamicin, therapy against acute myeloid leukemias (AMLs) targeting CD33 holds many promises. Here, and CD123 expression on AML blasts was studied by flow cytometry in a cohort of 319 patients detailed information French-American-British/World Health Organization (FAB/WHO) classification, cytogenetics molecular aberrations. AMLs 87.8% express would therefore be targetable therapies. Additionally, 9.4% without...
The current European LeukemiaNet (ELN) recommendations for acute myeloid leukemia (AML) propose a new risk reporting system, integrating molecular and cytogenetic factors subdividing the large heterogenous group of intermediate-risk patients into intermediate-I (IR-I) intermediate-II (IR-II). We assessed prognostic value classification in cohort patients.Complete data were available 1,557 1,862 treated AML96 trial. Patients assigned to proposed genetic groups from ELN recommendations,...
Purpose Identifying true therapeutic progress in patients with acute myeloid leukemia (AML) requires a comparison of treatment strategies and results on the basis uniform patient selection. To foster comparability across five clinical studies, we introduced common standard arm combined general upfront randomization performed prospective analyses adjustment for differences prognostic baseline characteristics. Patients Methods Whereas studies' own regimens differed chemotherapies, risk...
PURPOSE Nucleophosmin 1 ( NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) the fms-related tyrosine kinase 3 gene FLT3) is absent FLT3-ITD neg ) or present low allelic ratio ). The 2017 European LeukemiaNet guidelines assume this true regardless of accompanying cytogenetic abnormalities. We investigated validity assumption. METHODS analyzed associations between karyotype and outcome intensively treated...
A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ definition unbalanced aberrations as well number single aberrations. aim this study on 3526 AML was to redefine validate a cutoff for complexity regard adverse prognosis. Our demonstrated (1) pure...
Abstract The evaluation of bone marrow morphology by experienced hematopathologists is essential in the diagnosis acute myeloid leukemia (AML); however, it suffers from a lack standardization and inter-observer variability. Deep learning (DL) can process medical image data provides data-driven class predictions. Here, we apply multi-step DL approach to automatically segment cells images, distinguish between AML samples healthy controls with an area under receiver operating characteristic...
Background. Immune exhaustion and senescence are dominant dysfunctional states of effector T cells major hurdles for the success cancer immunotherapy. In current study, we characterized how acute myeloid leukemia (AML) promotes generation senescent-like CD8+ whether they have prognostic relevance.
Abstract Background Acute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being major cause death. Despite lower death rates reported from clinical trials, patient registry data suggest an early rate 20%, especially for elderly frail patients. Therefore, reliable diagnosis required as treatment with differentiation-inducing agents leads cure in the majority However, commonly relies on cytomorphology genetic confirmation...
Importance The ideal postremission strategy in intermediate-risk acute myeloid leukemia (AML) first complete remission (CR) has been a matter of debate. Objective To explore the optimal therapy for patients with AML after remission. Design, Settings, and Participants This investigator-initiated, open-label, 2-armed, phase 3 randomized clinical trial assessed at 16 hospitals Germany from February 2, 2011, until July 1, 2018. Key eligibility criteria included cytogenetically defined according...
Abstract Despite recent refinements in the diagnostic and prognostic assessment of CEBPA mutations AML, several questions remain open, i.e. implications different types basic region leucin zipper (bZIP) mutations, role co-mutations allelic state. Using pooled primary data analysis on 1010 -mutant adult AML patients, a comparison was performed taking into account type mutation (bZIP: either typical in-frame insertion/deletion (InDel) (bZIP InDel ), frameshift or nonsense inducing...
Individual differences in fear and fearlessness have been investigated at their extremes relation to markedly different forms of psychopathology--anxiety disorders psychopathy, respectively. A documented neural substrate fear-related traits is defensive reactivity as reflected aversive startle potentiation (ASP).The current study extended prior work by characterizing, a sample adult twins from the community (n = 2511), phenotypic etiologic structure self-report measures known be associated...
To assess the optimal cumulative dose of cytarabine for treatment young adults with acute myeloid leukemia (AML) within a prospective multicenter trial.Between 1996 and 2003, 933 patients (median age, 47 years; range 15 to 60 years) untreated AML were randomly assigned at diagnosis receive first consolidation therapy either intermediate-dose 12 g/m² (I-MAC) or high-dose 36 (H-MAC) combined mitoxantrone. Autologous hematopoietic stem-cell transplantation (10 g/m²) offered as second...
Abstract Acute graft-versus-host disease (aGvHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Steroid-resistant aGvHD is associated with poor outcome, no commonly accepted salvage therapy available for its treatment. Here, we report 58 adult patients treated mesenchymal stromal cells (MSCs) as steroid-refractory aGvHD. Third-party MSCs expanded in platelet lysate-containing medium were transfused at median dose 0.99 × 106 per kg...