A5022220588- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Chinese history and philosophy
- Immune cells in cancer
- Translation Studies and Practices
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Photodynamic Therapy Research Studies
- Pancreatic and Hepatic Oncology Research
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- earthquake and tectonic studies
- 3D Printing in Biomedical Research
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Tuberculosis Research and Epidemiology
Southern Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Army Medical University
2012-2024
Zhejiang Provincial People's Hospital
2018-2024
Hangzhou Medical College
2018-2024
Peking Union Medical College Hospital
2024
Peking University
2022-2024
Peking University Cancer Hospital
2022-2024
Daping Hospital
2012-2024
Beijing Radiation Center
2024
Abstract Background Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Recent evidence suggests that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and chemoresistance. However, regulatory mechanism lncRNAs resistance is not well established to date. In this research, we identified differentially expressed lncRNA investigated its role cancer. Methods LncRNA microarray qRT-PCR...
Reactive oxygen species (ROS) are crucial molecules in cancer therapy. Unfortunately, the therapeutic efficiency of ROS is unsatisfactory clinic, primarily due to their rigorous production conditions. By taking advantage intrinsic acidity and overproduction H2O2 tumor environment, we have reported an nanoreactor based on core–shell-structured iron carbide (Fe5C2@Fe3O4) nanoparticles (NPs) through catalysis Fenton reaction. These NPs able release ferrous ions acidic environments...
In recent years, with the emergence of various kinds drug-resistant bacteria, existing antibiotics have become inefficient in killing these and formation biofilms has further weakened therapeutic effect. More problematically, massive use abuse caused severe side effects. Thus, development ultra-efficient safe antibacterial systems is urgently needed. Herein, a photodynamic therapy (PDT)-driven CO-controlled delivery system (Ce6&CO@FADP) developed for synergistic ablation biofilms....
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in inflammatory response. However, the of AhR IL-10 production by macrophages currently unknown. In this study, we investigated LPS-induced expression from AhR-KO mice and AhR-overexpressing RAW264.7 cells. was highly expressed after LPS stimulation through NF-κB pathway. Loss resulted reduced macrophages. Moreover, elevated Maximal dependent on non-genomic pathway closely related to Src STAT3. Furthermore,...
Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis.Herein, we identified the role of miR-148a cell proliferation.miR-148a knockdown inhibited proliferation lines.Conversely, overexpression promoted cycle progression.p27, a key inhibitor cycle, was verified as target miR-148a, indicating might downregulate p27 expression promote proliferation.Moreover, confirmed frequently dramatically downregulated advanced tissues,...
Hepatocellular carcinoma (HCC) is a common malignant tumor with limited treatment options. Conventional antitumor therapy combined traditional Chinese medicine (TCM) to limit progression has gradually become the focus of complementary and alternative therapies for HCC treatment. The Fuzheng Jiedu Xiaoji formulation (FZJDXJ) alleviates clinical symptoms patients inhibits progression, but its curative effect still requires extensive research mechanistic analysis.To explore effectiveness FZJDXJ...
Abstract Skin wound macrophages are key regulators of skin repair and their dysfunction causes chronic, non-healing wounds. Peroxisome proliferator-activated receptor gamma (PPAR γ ) regulates pleiotropic functions macrophages, but its contribution in healing is poorly defined. We observed that macrophage PPAR expression was upregulated during healing. Furthermore, deficiency ( PPARγ- knock out (KO)) mice exhibited impaired with reduced collagen deposition, angiogenesis granulation...
Tea catechins, such as (-)-epigallocatechin-3-O-gallate (EGCG), have been shown to effectively enhance immune activity and prevent cancer, although the underlying mechanism is unclear. Green tea catechins are instead converted catechin metabolites in intestine. Here, we show that these green CD4(+) T cell well natural killer (NK) activity. Our data suggest absence of a 4'-hydroxyl on this phenyl group (B ring) important for effect In particular, 5-(3',5'-dihydroxyphenyl)-γ-valerolactone...
The long non-coding RNA (lncRNA) has recently been shown to be important regulators involved in the progression of various human cancers. Small nucleolar host gene 6 (SNHG6) is a identified cancer-related lncRNA. However, clinical significance and biological function SNHG6 breast cancer (BC) are still unclear. In present study, we found that was highly expressed BC tissues cell lines, which associated with poorer clinicopathologic features. Knockdown inhibited proliferation, migration...
Long noncoding RNAs (lncRNAs) play vital roles in the development and progression of hepatocellular carcinoma (HCC). The recent study finds a strong correlation between lncRNA small nucleolar RNA host gene 7 (SNHG7) HCC metastasis. However, molecular mechanism by which SNHG7 regulates has not been investigated. In this study, we found that was highly expressed tissues compared to non-tumor tissues. Data from public databases consistently indicated up-regulated expression HCC. Furthermore,...
A proposed strategy to overcome multidrug resistance (MDR) of anticancer drugs in chemotherapy is disable the efflux function P-glycoprotein (P-gp). In this study, based on ring-merging and fragment-growing strategies, 105 novel benzo five-membered heterocycle derivatives were designed, synthesized, screened. Exploration structure-activity relationship (SAR) led identification d7 with low cytotoxicity promising reversal activity doxorubicin MCF-7/ADR cells. Furthermore, mechanism studies...
Glioblastoma (GBM) is the most aggressive and malignant glioma. Currently, a few modern surgical medical therapeutic strategies are applied for GBM, but prognosis of GBM patients remains poor, average median survival time only 14.6 months. In this study, we first found that levels miR-320a were decreased in both glioma cells. patients, elevated expression was associated with better prognosis. addition, insulin-like growth factor-1 receptor (IGF-1R) identified as key direct target miR-320a....