A5067939855- Zebrafish Biomedical Research Applications
- Virtual Reality Applications and Impacts
- Face recognition and analysis
- Erythrocyte Function and Pathophysiology
- Autism Spectrum Disorder Research
- Child Development and Digital Technology
- Interactive and Immersive Displays
- Emotion and Mood Recognition
- Fish Ecology and Management Studies
- Media Influence and Health
- Physiological and biochemical adaptations
- CRISPR and Genetic Engineering
- Neuroscience and Neuropharmacology Research
- Augmented Reality Applications
- Radiative Heat Transfer Studies
- Visual and Cognitive Learning Processes
- Hippo pathway signaling and YAP/TAZ
- Action Observation and Synchronization
- Motor Control and Adaptation
- Human Motion and Animation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intelligent Tutoring Systems and Adaptive Learning
- Hand Gesture Recognition Systems
- Innovative Human-Technology Interaction
- Hydrogen's biological and therapeutic effects
Institute of Software
2016-2025
Chinese Academy of Sciences
2016-2025
Center for Excellence in Brain Science and Intelligence Technology
2018-2024
University of Electronic Science and Technology of China
2024
University of Chinese Academy of Sciences
2018-2023
Ningde Normal University
2009-2023
Lanzhou University
2021-2022
First Hospital of Lanzhou University
2021-2022
State Key Laboratory of Computer Science
2020
Children's Hospital of Fudan University
2015-2017
Blood flow is known to regulate cerebrovascular development through acting on vascular endothelial cells (ECs). As an indispensable component of the neurovascular unit, brain pericytes physically couple with ECs and play vital roles in blood-brain barrier integrity maintenance coupling. However, it remains unclear whether blood affects pericyte development. Using vivo time-lapse imaging larval zebrafish, we monitored developmental dynamics found that they proliferate expand their population...
How general anesthesia causes loss of consciousness has been a mystery for decades. It is generally thought that arousal-related brain nuclei, including the locus coeruleus (LC), are involved. Here, by monitoring locomotion behaviors and neural activities, we developed larval zebrafish model studying induced propofol etomidate, two commonly used intravenous anesthetics. Local lesion LC neurons via two-photon laser-based ablation or genetic depletion norepinephrine (NE; neuromodulator...
In light of the growing proportion older individuals in our society, timely diagnosis Alzheimer's disease has become a crucial aspect healthcare. this paper, we propose non-invasive and cost-effective detection method based on speech technology. The employs pre-trained language model conjunction with techniques such as prompt fine-tuning conditional learning, thereby enhancing accuracy efficiency process. To address issue limited computational resources, study efficient LORA to construct...
Human computer interaction is one of the core technologies virtual reality, which has an important significance on promoting widely use reality and improving user experience. Due to development various sensors hardwares, human technology in made remarkable progress. This paper firstly introduces paradigm then makes a summary about main research contents trends augmented technologies, including 3D interaction, hand gesture handheld devices speech haptic multimodal interaction. Finally,...
Recent work introduced the notion of 'emotional challenge' promising for understanding more unique and diverse player experiences (PX). Although emotional challenge has immediately attracted HCI researchers' attention, concept not been experimentally explored, especially in virtual reality (VR), one latest gaming environments. We conducted two experiments to investigate how affects PX when separately from or jointly with conventional VR PC conditions. found that relatively exclusive induced...
SHANK3 is a scaffolding protein that binds to various synaptic proteins at the postsynaptic density (PSD) of excitatory glutamatergic synapses. not only strongly implicated in autism spectrum disorders (ASD) but also plays critical role human Phelan-McDermid syndrome (22q13.3 deletion syndrome). Accumulated experimental evidence demonstrates zebrafish model system useful for studying functions ASD-related gene during early development. However, many basic features shank3 transcript...
Challenge is the core element of digital games. The wide spectrum physical, cognitive, and emotional challenge experiences provided by modern games can be evaluated subjectively using a questionnaire, CORGIS, which allows for post hoc evaluation overall experience that occurred during game play. Measuring this dynamically objectively, however, would allow more holistic view moment-to-moment players. This study, therefore, explored potential detecting perceived from physiological signals. For...
Abstract Cre/loxP system is a powerful tool to manipulate the genome. Transgenic animals expressing Cre recombinase in specific tissues or cells have been widely used for conditional gene targeting, lineage tracing, and other genetic analyses. In zebrafish, transgenic line with stable expression of cell subtypes has not generated its functional activity remains be defined. Here we report establishment fish Tg ( zlmo2:Cre ), which specifically expresses primitive hematopoietic progenitors...
In order to use mathematical methods study how cognitive reappraisal strategies affect the output state of emotions, Gross's strategy is transformed into a quantitative parameter which proposed describe general perception emotional events on basis emotion regulation. According regulation model, Finite State Machine (FSM) model used for describing process transition and Likert 5 grading scale introduced level an individual's according participant's self-evaluation. The experimental results...
Most intervention methods used for social skills training in children with autism are dedicated to high-functioning (HFA). However, extensive neurological and developmental disorders of low-functioning (LFA) have hampered their adoption. In this study, we observed interviewed LFA, teachers, from a local educational institution, better understand the children's needs barriers. Then, aim aiding activities, illustrate design process SqueeBall, an interactive playground equipment. We evaluated...
Modeling the endpoint uncertainty of moving target selection with crossing is essential to understand factors such as speed-accuracy trade-off and interaction efficiency in crossing-based user interfaces dynamic contents. However, there have been few studies looking into this research topic HCI field. This paper presents a Quaternary-Gaussian model quantitatively measure selection. To validate model, we conducted an experiment discrete tasks on five factors, i.e., initial distance, size,...
Abstract The circadian clock orchestrates a wide variety of physiological and behavioral processes, enabling animals to adapt daily environmental changes, particularly the day-night cycle. However, clock’s role in developmental processes remains unclear. Here, we employ vivo long-term time-lapse imaging retinotectal synapses optic tectum larval zebrafish reveal that synaptogenesis, fundamental process for neural circuit formation, exhibits rhythm. This rhythmicity arises primarily from...
The blossoming semi-automated vehicles allow drivers to engage in various non-driving-related tasks, which may stimulate diverse emotions, thus affecting takeover safety. Though the effects of emotion on behavior have recently been examined, how effectively obtain and utilize drivers' emotions for predicting remains largely unexplored. We propose EmoTake, a deep learning-empowered system that explores emotional physical states predict readiness, reaction time, quality. key enabler is neural...