A5100745507- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Nanoplatforms for cancer theranostics
- Particle Detector Development and Performance
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Quantum Chromodynamics and Particle Interactions
- Photoacoustic and Ultrasonic Imaging
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- X-ray Diffraction in Crystallography
- Gene expression and cancer classification
- Photodynamic Therapy Research Studies
- Mobile Ad Hoc Networks
- Click Chemistry and Applications
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Opportunistic and Delay-Tolerant Networks
- Brain Tumor Detection and Classification
- Osteoarthritis Treatment and Mechanisms
- Supramolecular Self-Assembly in Materials
- Crystallization and Solubility Studies
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Vehicle Dynamics and Control Systems
Nankai University
2024-2025
State Key Laboratory of Medicinal Chemical Biology
2024-2025
Wuhan University
2024
Ningbo Institute of Industrial Technology
2024
Chinese Academy of Sciences
2024
Anhui University
2023-2024
Affiliated Zhongshan Hospital of Dalian University
2023-2024
Tsinghua University
2024
NTT Basic Research Laboratories
2024
Linyi University
2021-2023
Abstract Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate with structures reconstruct the microenvironment fulfill satisfying repair effects. In this review article, we first discuss various strategies design construction of promote defect repair, especially including structural scaffold integration bioactive substances together application external stimuli....
The detection of biological molecules and their interactions is a significant component modern biomedical research. In current biosensor technologies, simultaneous limited to small number analytes by the spectral overlap signals. We have developed an NMR-based xenon that capitalizes on enhanced signal-to-noise, simplicity, chemical-shift sensitivity laser-polarized detect specific biomolecules at level tens nanomoles. present results using “functionalized” biotin-modified supramolecular cage...
With the rapid accumulation of our knowledge on diseases, disease-related genes and drug targets, network-based analysis plays an increasingly important role in systems biology, pharmacology translational science. The new release VisANT aims to provide functions facilitate convenient network therapies, drugs. improved understanding mechanisms complex diseases actions through analysis, novel methods (e.g., repositioning, multi-target combination therapy) can be designed. More specifically,...
Abstract Background Osteoarthritis (OA) is one of the most common rheumatic diseases which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients’ daily life. It was reported that non-coding RNAs play vital roles in OA. However, regulation mechanism ncRNA OA pathogenesis has not been fully elucidated. Methods The expression SNHG7, miR-34a-5p SYVN1 detected using qRT-PCR tissues, serum cells. protein SYVN1, PCNA, cleavage-caspase 3, beclin1 LC3 were measured...
Abstract The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be facilitated if motor axon degeneration could more readily visualized. Here we demonstrate that stimulated Raman scattering (SRS) microscopy used to sensitively monitor peripheral nerve in ALS mouse models autopsy materials. Three-dimensional imaging pre-symptomatic SOD1 data processing by a correlation-based algorithm revealed significant nerves detected coincidentally with the earliest detectable...
Abstract Increasing evidence has demonstrated that lactate and adenosine triphosphate (ATP) both play important roles in regulating abnormal metabolism the tumor microenvironment. Herein, an O 2 self‐supplying catalytic nanoagent, based on tannic acid (TA)–Fe(III) coordination complexes‐coated perfluorooctyl bromide (PFOB) nanodroplets with oxidases (LOX) loading (PFOB@TA–Fe(III)–LOX, PTFL), is designed for cascade metabolic‐chemodynamic therapy (CDT) by dual‐depletion of ATP hydroxyl • OH...
An orthogonal tryptophanyl–transfer RNA (tRNA) synthetase (TrpRS)-mutant opal suppressor tRNA Trp ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin{equation*}{\mathrm{mutRNA}}_{{\mathrm{UCA}}}^{{\mathrm{Trp}}}\end{equation*}\end{document} ) pair was generated for use in mammalian cells. The anticodon loop of the Bacillus...
We describe here the development of site-specific antibody-polymer conjugates (APCs) for selective delivery small interference RNAs (siRNAs) to target cells. APCs were synthesized in good yields by conjugating an aminooxy-derivatized cationic block copolymer anti-HER2 Fab or full-length IgG means genetically encoded p-acetyl phenylalanine (pAcF). The all showed binding affinity comparable that HER2 as their native counterparts and no significant cellular cytotoxicity. Mutant S202-pAcF...
Abstract Self‐assembly in living cells represents one versatile strategy for drug delivery; however, it suffers from the limited precision and efficiency. Inspired by viral traits, we here report a cascade targeting‐hydrolysis‐transformation (THT) assembly of glycosylated peptides holistically resembling infection efficient cargo delivery combined tumor therapy. We design peptide via incorporating β‐galactose‐serine residue into bola‐amphiphilic sequences. Co‐assembling with two counterparts...
The unnatural amino acid p-azidophenylalanine was genetically introduced into a phage-displayed peptide and mutant Z-domain protein. These azide-containing proteins were selectively efficiently modified by using fluorescein-derived phosphines the Staudinger ligation reaction (see picture). This work provides powerful new tool for selective modification of with variety synthetic agents. Supporting information this article is available on WWW under...
In light of the growing proportion older individuals in our society, timely diagnosis Alzheimer's disease has become a crucial aspect healthcare. this paper, we propose non-invasive and cost-effective detection method based on speech technology. The employs pre-trained language model conjunction with techniques such as prompt fine-tuning conditional learning, thereby enhancing accuracy efficiency process. To address issue limited computational resources, study efficient LORA to construct...
Protein carboxyl methyltransferase (PCMT) restores aspartate isomers in proteins and plays a critical role cancer prognosis. However, vivo detection of PCMT remains challenging. Here, we report the isomerization-regulated situ assembly peptides into supramolecular probes within living cells for bladder cancer. The peptide consists alternating hydrophobic hydrophilic residues contains an isoAsp residue as kinked site to prevent facial amphiphilicity peptide. Exposure converts Asp peptide,...
The construction of a sensitive strategy for in situ visualizing and dynamic tracing intracellular microRNA is great importance. Via the toehold-mediated strand displacement process, catalytic hairpin assembly (CHA) could offer several hundreds-fold signal amplifications. However, CHA may produce certain background interferences since exist normal cells. In this work, we constructed an endogenously sequentially activated amplification to provide amplified dual-color fluorescence imaging...
Photoacoustic (PA) imaging uses photon–phonon conversion for high-resolution tomography of biological tissues and functions. Exogenous contrast agents are often added to improve the image quality, but interference from endogenous molecules diminishes sensitivity specificity. We report a background-free PA technique based on active modulation signals via magnetic alignment Fe3O4@Au hybrid nanorods. Switching field direction creates enhanced deactivated modalities, enabling simple pixel...