A5100320098- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Glutathione Transferases and Polymorphisms
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Perovskite Materials and Applications
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Organic Electronics and Photovoltaics
- Cancer therapeutics and mechanisms
- Conducting polymers and applications
- Virus-based gene therapy research
University of Chicago
2018-2025
Tsinghua University
2015-2024
Southeast University
2024
Capital Normal University
2022-2024
Rutgers, The State University of New Jersey
2023
Shandong University
2023
Capital Medical University
2023
Chinese Academy of Agricultural Sciences
2022
Nanjing Medical University
2022
Chinese University of Hong Kong
2022
Abstract Organic‐inorganic hybrid perovskites have emerged as highly promising candidates for photovoltaic applications, owing to the exceptional optoelectronic properties and low cost. Nonetheless, performance stability of solar cells suffer from defect states perovskite films aroused by non‐optically active phases non‐centralized crystal orientation. Herein, a versatile organic molecule, Hydantoin, modulate crystallization perovskite, is developed. Benefiting diverse functional groups,...
Abstract The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be facilitated if motor axon degeneration could more readily visualized. Here we demonstrate that stimulated Raman scattering (SRS) microscopy used to sensitively monitor peripheral nerve in ALS mouse models autopsy materials. Three-dimensional imaging pre-symptomatic SOD1 data processing by a correlation-based algorithm revealed significant nerves detected coincidentally with the earliest detectable...
Abstract Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, circRNAs, have been found to promote or inhibit by acting on receptors, signal transducers transcriptional effectors. The identification these regulators their underlying molecular mechanisms provides important implications for how target this therapeutically. review, we...
Cell membrane chromatography (CMC) is an ideal method for screening potential active components acting on target cell membranes from a complex system, such as herbal medicines. But due to the decay and falling-off of membranes, CMC column suffers short life span low reproducibility. This has greatly limited application this model, especially when materials are hard obtain. To solve problem, novel type (3-aminopropyl)triethoxysilane (APTES)-decorated silica gel was employed. The decorated...
Immune tolerance contributes to resistance conventional cancer therapies such as radiation. Radiotherapy induces immunogenic cell death, releasing a burst of tumor antigens, but this appears insufficient stimulate an effective antitumor immune response. Radiation also increases infiltration cytotoxic T lymphocytes (CTLs), their effector function is short lived. Although CTL exhaustion may be at fault, combining checkpoint blockade with radiation restore in most patients. An alternative model...
Introduction Altered Immunoglobulin G (IgG) N-glycosylation is associated with aging, inflammation, and diseases status, while its effect on esophageal squamous cell carcinoma (ESCC) remains unknown. As far as we know, this the first study to explore validate association of IgG carcinogenesis progression ESCC, providing innovative biomarkers for predictive identification targeted prevention ESCC. Methods In total, 496 individuals ESCC (n=114), precancerosis (n=187) controls (n=195) from...
Cellular senescence has recently been recognized as a hallmark of cancer, reflecting its association with aging and inflammation, role response to deregulated proliferation oncogenic stress, induction by cancer therapies such radiation, chemotherapy, targeted agents. While therapy-induced (TIS) linked resistance, recurrence, metastasis normal tissue toxicity, TIS the potential enhance therapy stimulate anti-tumor immunity. In this review, we examine Jekyll Hyde nature senescent cells (SnCs),...
Background: The ability of radiotherapy (RT) to drive anti-tumor immunity is limited by adaptive resistance. While RT induces inflammation and recruits activated tumor-infiltrating lymphocytes (TILs), including cytotoxic T (CTLs), the resulting radiation- IFNγ-dependent PD-L1 expression restores an immunosuppressed tumor microenvironment. Unleashing effective response may require precise sequencing checkpoint blockade immunotherapy (CBI) block signaling before it can mediate its suppressive...
The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part 40 years. All known D1-selective are catecholamines that bring about receptor desensitization and undergo rapid metabolism, thus limiting their utility as a therapeutic chronic illness such schizophrenia Parkinson's disease. Our high-throughput screening efforts on yielded single non-catecholamine hit PF-4211 (6) was developed into series potent agonist leads high oral...
The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism advanced cancer is often ascribed to answering a higher demand for intermediates required rapid tumor cell growth. Instead, recent discoveries have pointed an alternative role metabolites as cofactors chromatin modifiers other protein posttranslational modification enzymes cells. Beyond epigenetic mechanisms regulating gene expression, many also modulate DNA repair, raising the question...
OLA1, an Obg-family GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translational control, but its physiological functions remain obscure. Here we report that mouse embryos lacking OLA1 have stunted growth, delayed development leading to immature organs—especially lungs—at birth, and frequent perinatal lethality. Proliferation of primary Ola1−/− embryonic fibroblasts (MEFs) is impaired due defective cell cycle progression, associated with reduced cyclins D1 E1,...
The binding of DNA-dependent protein kinase catalytic subunit (DNA-PKcs, also known as PRKDC) to Ku proteins at DNA double-strand breaks (DSBs) has long been considered essential for non-homologous end joining (NHEJ) repair, providing a rationale use DNA-PKcs inhibitors cancer therapeutics. Given lagging clinical translation, we reexamined mechanisms and observed instead that DSB repair can proceed independently DNA-PKcs. While radiation-induced DSBs was blocked in cells expressing shRNAs...
Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) expressed in ∼90% of cancer cells where it confers the capacity limitless proliferation. Along with its established role telomere lengthening, also serves noncanonical extra-telomeric roles oncogenic signaling, resistance to apoptosis, enhanced DNA damage response. We report new class natural-product-inspired covalent...
Uracil misincorporation during DNA replication is a major cell toxic event, of which cancer cells overcome by activating the dUTPase enzyme. The DUT gene only known in human. Despite reports on common upregulations cancers, role human hepatocellular carcinoma (HCC) remains largely undetermined. In this study, we investigated mechanism underlying biology HCC and tumor susceptibility to drug targeting dUTPase. Overexpression was found 42% tumors correlated with advanced stage HCC. Knockout...
Human degenerative disc disease (DDD) is characterized by progressive loss of human nucleus pulposus (HNP) cells and extracellular matrix, in which the massive deposition are secreted HNP cells. Cell therapy to supplement degenerated discs has been thought be a promising strategy treat DDD. However, obtaining large quality fully functional severely hampered limited proliferation capacity vitro. Previous studies have used lipofectamine or recombinant adeno-associated viral (rAAV) vectors...
Expression of telomerase reverse transcriptase (TERT) is a hallmark cancer, maintaining telomere length and integrity to enable replicative immortality. However, TERT also serves multiple enzyme-dependent -independent functions support cell growth survival, including enhanced DNA damage response. Agents that inhibit activity prevent elongation but may fail limit other mediate cancer therapy resistance. Thus, we applied structure-based design, modular synthesis, biochemical assays toward...
Expression of telomerase reverse transcriptase (TERT) is a hallmark cancer, maintaining telomere length and integrity to enable replicative immortality. However, TERT also serves multiple enzyme-dependent -independent functions support cell growth survival, including enhanced DNA damage response. Agents that inhibit activity prevent elongation but may fail limit other mediate cancer therapy resistance. Thus, we applied structure-based design, modular synthesis, biochemical assays toward...
Expression of telomerase reverse transcriptase (TERT) is a hallmark cancer, maintaining telomere length and integrity to enable replicative immortality. However, TERT also serves multiple enzyme-dependent -independent functions support cell growth survival, including enhanced DNA damage response. Agents that inhibit activity prevent elongation but may fail limit other mediate cancer therapy resistance. Thus, we applied structure-based design, modular synthesis, biochemical assays toward...
Abstract Freshwater scarcity threatens human survival, particularly in extreme environments like deserts, oceans, and space. Compatible atmospheric water harvesting undrinkable purification offer an affordable approach to solving freshwater these environments. Nonetheless, developing composite sorbent attain efficient remains challenging. Hence, a portable hybrid hygroscopic powder (HLC powder) consisting of hydroxypropyl chitosan, dibenzaldehyde‐functional poly(ethylene glycol), lithium...