A5100414129- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Retinal and Optic Conditions
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Immune cells in cancer
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Vestibular and auditory disorders
- Geochemistry and Geologic Mapping
- Ocular Diseases and Behçet’s Syndrome
- Neurobiology and Insect Physiology Research
- Image Processing and 3D Reconstruction
- Alzheimer's disease research and treatments
- Image and Object Detection Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical measurement and interference techniques
- Anesthesia and Neurotoxicity Research
- Ophthalmology and Eye Disorders
- Neurological Disorders and Treatments
- Acupuncture Treatment Research Studies
Dalian Medical University
2023-2025
First Affiliated Hospital of Dalian Medical University
2023-2025
Chinese Academy of Sciences
2001-2024
Lanzhou University Second Hospital
2023-2024
Shanghai Jiao Tong University
2018-2024
Xi'an Jiaotong University
2022-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Shandong Institute of Automation
2023-2024
Zhengzhou University of Industrial Technology
2024
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic search, we identified ALDH2 deficiency in stroke-prone spontaneously hypertensive rats (SHR-SP) compared with (SHR). We concluded the causative role of neuronal injury overexpression or activation conferred neuroprotection by clearing 4-HNE vitro studies. Further, ALDH2-knockdown revealed absence neuroprotective effects PKCε....
Transient sexual experiences can have long-lasting effects on behavioral decisions, but the neural coding that accounts for this change is unclear. We found ejaculation experience selectively activated estrogen receptor 2 (Esr2)-expressing neurons in bed nucleus of stria terminalis (BNST)-BNSTEsr2-and led to persistent decreases firing threshold days, during which time mice displayed satiety. Inhibition hyperexcited BNSTEsr2 elicited fast mating recovery satiated both sexes. In males, such...
The accumulation of large datasets and increasing data availability have led to the emergence data-driven paleontological studies, which reveal an unprecedented picture evolutionary history. However, fast-growing quantity complication modalities make processing laborious inconsistent, while also lacking clear benchmarks evaluate collection generation, performances different methods on similar tasks. Recently, artificial intelligence (AI) has become widely practiced across scientific...
In the study of circadian rhythms, it has been a puzzle how limited number clock genes can control diverse aspects physiology. Here we investigate gene expression genome-wide using larval zebrafish as model system. We made use spatial atlas to in various tissues and cell types. Comparison data between mouse revealed nearly anti-phase relationship allowed us detect novel evolutionarily conserved vertebrates. identified three groups with distinct responses light entrainment: fast light-induced...
Abstract: Eucommia ulmoides Oliv. is a famous traditional Chinese medicine which exhibits anti-oxidative stress ability and neuro-protective effects. Aucubin the predominant component of Our present study intended to investigate aucubin’s potential protective effects on neurons against epilepsy in hippocampus by establishing lithium-pilocarpine induced status epilepticus (SE) rat model vivo. (at low dose high 5[Formula: see text]mg/kg 10[Formula: text]mg/kg, respectively) was administered...
The characteristics and role of NOD-like receptor (NLR) signaling pathway in high-grade gliomas were still unclear. This study aimed to reveal the association NLR with clinical heterogeneity glioblastoma (GBM) patients, explore hub genes occurrence development GBM. Transcriptomic data from 496 GBM patients complete prognostic information obtained TCGA, GEO, CGGA databases. Using NMF clustering algorithm expression profiles genes, these classified into different subtypes. activity immune...
It has been shown that activated microglia in brain releasing proinflammatory cytokines (PICs) contribute to the progression of cardiovascular diseases. In this study, we tested hypothesis microglial activation hypothalamic paraventricular nucleus (PVN), induced by high-salt diet, increases oxidative stress via PICs and promotes sympathoexcitation development hypertension.High-salt diet was given male Dahl salt-sensitive rats induce hypertension. Those were bilaterally implanted with cannula...
Integration of muscle, connective tissue and skeletal patterning during development is essential for proper functioning the musculoskeletal system. How this integration achieved poorly understood. There ample evidence suggesting that pattern programmed autonomously, whereas muscle is, most part, non-cell-autonomously. Connective tissues depend upon both their survival development. Here, we employed a novel approach to dissect coordination mouse limb Using conditional gain- loss-of-function...
Microglia are the primary immune cells in brain. Under pathological conditions, they become activated and participate scavenging, inflammation tissue repair response to brain injury. While function underlying mechanism of microglia have been intensively studied past decades, physiological functions resting remain largely underestimated. In our recent work, by simultaneously monitoring both motility microglial processes activity surrounding neurons intact zebrafish optic tectum, we examined...
Oleoylethanolamide (OEA) has been demonstrated to be a feasible protectant in ischemic stroke. However, the mechanism for OEA-afforded neuroprotection remains elusive. The present study aimed investigate neuroprotective effects of OEA on peroxisome proliferator-activated receptor α (PPARα)-mediated microglia M2 polarization after cerebral ischemia. Transient middle artery occlusion (tMCAO) was induced 1 h wild-type (WT) or PPARα-knock-out (KO) mice. Mouse small glioma cells (BV2) and primary...
Recently, deep learning has reached significant advancements in various image-related tasks, particularly medical sciences. Deep neural networks have been used to facilitate diagnosing images generated from observation techniques including CT (computed tomography) scans. As a non-destructive 3D imaging technique, scan also widely paleontological research, which provides the solid foundation for taxon identification, comparative anatomy, functional morphology, etc. However, labeling and...
Abstract Background Microglia are highly motile phagocytic cells in the healthy brain with surveillance and clearance functions. Although microglia have been shown to engulf cellular debris following insult, less is known about their function absence of injury. Propofol can inhibit microglial activity, including phagocytosis. Milk fat globule epidermal growth factor 8 (MFG-E8), as a regulator microglia, plays an essential role process. However, whether MFG-E8 affects alteration phagocytosis...
Abstract The circadian clock orchestrates a wide variety of physiological and behavioral processes, enabling animals to adapt daily environmental changes, particularly the day-night cycle. However, clock’s role in developmental processes remains unclear. Here, we employ vivo long-term time-lapse imaging retinotectal synapses optic tectum larval zebrafish reveal that synaptogenesis, fundamental process for neural circuit formation, exhibits rhythm. This rhythmicity arises primarily from...
Abstract Background The milk fat globule membrane (MFGM) contains various bioactive components which have been shown to maintain gut barrier integrity. This study aimed evaluate the protective effects of MFGM on intestinal function and its possible mechanisms in a rat model short bowel syndrome (SBS). Materials Methods Five‐week‐old male Sprague‐Dawley rats were divided into 3 groups (n = 8 per group), consisting Sham group submitted massive small‐bowel resection then supplemented with...
Clinical research reveals that colon plays an important role in mitigating the effects of short-bowel syndrome (SBS). Previously, we showed milk fat globule membrane (MFGM) had protective on gut barrier integrity rat SBS model. Here, used same model to investigate enteral MFGM supplementation microbiota and colonic-mucus-barrier function its related mechanisms.We randomly divided 24 male Sprague-Dawley rats into 3 groups: Sham, (rats with massive small-bowel resection), SBS+MFGM (SBS...
The three-dimensional (3D) genome organization plays a critical role in the regulation of gene expression eukaryotic organisms. In unicellular malaria parasite Plasmodium falciparum, high-order chromosome has emerged as an important epigenetic pathway mediating expression, particularly for virulence genes, but related architectural factors and underlying mechanism remain elusive. Herein, we have identified high-mobility-group protein HMGB1 factor maintenance P. falciparum Genome-wide...