A5065476950- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Anorectal Disease Treatments and Outcomes
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Machine Learning in Bioinformatics
- Peroxisome Proliferator-Activated Receptors
- Machine Learning and Algorithms
- Colorectal and Anal Carcinomas
- Protein Structure and Dynamics
- Bioinformatics and Genomic Networks
- Immune Response and Inflammation
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Glaucoma and retinal disorders
- Genomics and Phylogenetic Studies
- Inflammasome and immune disorders
- Inflammation biomarkers and pathways
- Machine Learning in Healthcare
- Educational Technology and Assessment
- Immune Cell Function and Interaction
- Frailty in Older Adults
First Affiliated Hospital of Xiamen University
2024
Northwestern University
2017-2024
Xiamen Medical College
2018-2024
Cohort (United Kingdom)
2023
Air Force Engineering University
2021
Boston University
2018
Erasmus MC
2018
Institute for Neurodegenerative Disorders
2018
The University of Texas Health Science Center at San Antonio
2018
Framingham Heart Study
2018
To determine if measures of adipokines and other blood lipids differentiate between normal controls persons with Alzheimer's disease (AD), we examined levels leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated l
Transient receptor potential (TRP) channels are involved in the development and progression of tumors. However, their role colorectal cancer (CRC) remains unclear, this study aims to investigate TRP-related genes CRC.
Abstract The association between anal fistula patients and colorectal cancer, as well the potential pathophysiological mechanisms, remains unclear. To explore relationship cancer its mechanisms. Analysis of GEO TCGA databases. Disease‐related genes were also referenced from Coremine Medical, GeneCard OMIM. Core hub identified through protein–protein interaction analysis by intersecting differentially expressed datasets with disease data. On one hand, a prognostic model was developed using...
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated for their biomedical applications in magnetic resonance imaging, targeting therapy, cell labeling, etc. It has well documented that macrophages produce interleukin (IL)‐1β via several signaling pathways, such as inflammasome activation response to particles including silica, asbestos and urea crystals with lipopolysaccharide priming. However, the size dose effects of SPIONs on mechanisms remain...
Prediction of patient-centered outcomes in hospitals is useful for performance benchmarking, resource allocation, and guidance regarding active treatment withdrawal care. Yet, their use by clinicians limited the complexity available tools amount data required. We propose to Disjunctive Normal Forms as a novel approach predict hospital 90-day mortality from instance-based patient data, comprising demographic, genetic, physiologic information large cohort patients admitted with severe...
Oleoylethanolamide (OEA) has been demonstrated to be a feasible protectant in ischemic stroke. However, the mechanism for OEA-afforded neuroprotection remains elusive. The present study aimed investigate neuroprotective effects of OEA on peroxisome proliferator-activated receptor α (PPARα)-mediated microglia M2 polarization after cerebral ischemia. Transient middle artery occlusion (tMCAO) was induced 1 h wild-type (WT) or PPARα-knock-out (KO) mice. Mouse small glioma cells (BV2) and primary...
To study the therapeutic effect of Quyu (QY) Shengxin (SX) decoction (QYSXD) in mice with dextran sulfate sodium- (DSS-) induced ulcerative colitis and to investigate effects QYSXD on regulation receptor-interacting protein kinase 1 (RIP1)/receptor-interacting 3 (RIP3)/nucleotide-binding oligomerization domain-like receptor family pyrin domain (NLRP3) signaling pathway.Thirty-six were randomly divided into following 6 groups: experimental group (QYSX group), model (DSS positive control...
Background. One critical issue in protein three-dimensional structure prediction using either ab initio or comparative modeling involves identification of high-quality structural models from generated decoys. Currently, clustering algorithms are widely used to identify near-native models; however, their performance is dependent upon different conformational decoys, and, for some algorithms, the accuracy declines when decoy population increases. Results. Here, we proposed two...
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively applied in biomedical fields, such as magnetic resonance imaging and nanocarriers. However, the biosafety of SPIONs is not completely established, especially their effect on immune system inflammatory responses. Toll‐like receptor (TLR) signaling essential for many acute chronic human diseases. Regulation TLR responses with drugs helpful these conditions. In this study, we investigated effects 10 30 nm macrophages...
RNA virus phenotypic changes often result from multiple alternative molecular mechanisms, where each mechanism involves to a small number of key residues. Accordingly, we propose learn genotype-phenotype functions, using Disjunctive Normal Form (DNF) as the assumed functional form. In this study develop DNF learning algorithms that attempt construct predictors Boolean combinations covariates. We demonstrate algorithm's consistency and efficiency on simulated sequences, establish their...
In order to design an intelligent diagnosis expert system which helps grass-roots maintenance engineers quickly and accurately locate the fault unit of aircraft, constructing aircraft knowledge graph as base is proposed in this paper. Fault model based on ontology describes what entity concepts relationship between these exist introduced, identification relation extraction method deep learning illustrated
Objective Previous studies have revealed that Propane-2-sulfonic acid octadec-9-enyl-amide(N15) exerts a protective role in the inflammatory response after ischemic stroke and neuronal damage. However, little is known about N15 Alzheimer's disease (AD). The aim of this study was to investigate effects on AD explore underlying molecular mechanism.
Our previous study showed that propane-2-sulfonic acid octadec-9-enyl-amide (N15), a novel peroxisome proliferator-activated receptor α and γ (PPARα/γ) dual agonist, inhibits inflammatory responses in tumor necrosis factor alpha (TNFα)-induced vascular endothelial cells or lipopolysaccharide (LPS)-induced human myeloid leukemia mononuclear cells-1. However, little is known about whether N15 applies to other pathological neuroinflammatory conditions. In the present study, we detected effect...
RNA viruses such as HIV, Influenza, impose very significant disease burden throughout the world. Identifying key protein residue determinants that affect a given viral phenotype is an important step in learning genotype-phenotype mapping and making clinic decisions. This identification currently done through laborious experimental process which arguably inefficient, incomplete, unreliable. We describe supervised combinatorial filtering algorithm systematically efficiently infers correct set...
In English writing, learners will inevitably make a variety of grammatical mistakes, especially in subordinate clause connective. To alleviate high error rate connective clauses Chinese students' an automatic correction model for is studied and implemented from the perspective machine learning — genetic algorithm (GA) k-nearest neighbor (KNN) combination model. Firstly, feature selection based on GA adopted to reduce time consuming space cost, improve accuracy correction. Secondly, through...