A5028353181- Neural and Behavioral Psychology Studies
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Memory Processes and Influences
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Spatial Neglect and Hemispheric Dysfunction
- Functional Brain Connectivity Studies
- Cognitive Functions and Memory
- Neurobiology of Language and Bilingualism
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Psychosomatic Disorders and Their Treatments
- Glaucoma and retinal disorders
- Mental Health Research Topics
- Cholinesterase and Neurodegenerative Diseases
- Cognitive Abilities and Testing
- Neurological Disorders and Treatments
- Clinical Reasoning and Diagnostic Skills
- Mental Health and Psychiatry
- Deception detection and forensic psychology
- Face Recognition and Perception
- Multisensory perception and integration
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Center for Pain and the Brain
2022-2025
McLean Hospital
2005-2025
Massachusetts General Hospital
2008-2023
Faculdade de Medicina de Marília
2019-2023
Universidade de São Paulo
2019-2023
Beth Israel Deaconess Medical Center
2012-2020
Advocate Lutheran General Hospital
2020
Kessler Foundation
2015
Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes cortical thickness and synaptic density response to physical activity environmental enrichment. Previous studies suggest that exercise can augment BDNF levels, both serum the brain, but no other study examined how different types of activities compare with their ability affect levels. By using balanced cross over experimental design, we exposed nineteen healthy older adults 35-minute sessions...
The physiological basis for the striking decrease of attention to novel events following frontal lobe injury is poorly understood. In this study, event-related potentials (ERPs) were recorded from patients with damage and matched subjects, who controlled duration viewing background, target stimuli. Frontal did not differ normal controls in terms age, education, estimated IQ or mood. However, they judged be more apathetic as measured by self-report informants' ratings. Patients exhibited...
Two adult patients are described who suffered bilateral prefrontal damage early in life and subsequently came to psychiatric attention because of severely aberrant behaviour. A battery developmental psychology paradigms (not previously used assess neurologically impaired individuals) showed that social moral development these 2 was arrested at an immature stage. In comparison with other types brain which disrupt cognitive development, frontal acquired appears provide the neurological...
<h3>Objective</h3> To investigate the relationship between magnetic resonance imaging regional lesion burden and cognitive performance in multiple sclerosis (MS) over a 4-year follow-up period. <h3>Design</h3> Twenty-eight patients with MS underwent took Brief, Repeatable Battery of Neuropsychological Tests Multiple Sclerosis at baseline, 1-year, follow-up. An automated 3-dimensional detection method was used to identify lesions within anatomical regions on proton density T2-weighted images....
Currently Alzheimer's disease, which affects more than 20 million people worldwide, can only be definitively diagnosed by histological examination of brain tissue obtained at autopsy or biopsy. There is a great need for an early, noninvasive, sensitive, and easily administered diagnostic test disease. Here it reported that patients with probable disease standard clinical criteria exhibited marked hypersensitivity in their pupil dilation response to cholinergic antagonist, tropicamide, placed...
Abstract This study took advantage of the subsecond temporal resolution ERPs to investigate mechanisms underlying age- and performance-related differences in working memory. Young old subjects participated a verbal n-back task with three levels difficulty. Each group was divided into high low performers based on accuracy under 2-back condition. Both low-performing young exhibited impairments preliminary mismatch/match detection operations (indexed by anterior N2 component). may have...
Objective: To determine the efficacy of donepezil hydrochloride for treatment Alzheimer disease in patients drawn from clinical practice.Design: Two-center, randomized, placebo-
The authors examined false recognition of semantic associates in patients with probable Alzheimer's disease (AD), older adults, and young adults using a paradigm that provided rates after single multiple exposures to word lists. Using corrected scores control for unrelated alarms, the found (a) level list exposure was lower AD than controls; (b) across 5 trials, increased patients, decreased showed fluctuating pattern adults; (c) all groups an increase true over trials. Analyses suggested...
Previous research has shown that patients with Alzheimer's disease show increasing levels of false recognition across five repeated study–test trials semantic associates. The present study tested the hypotheses (i) was partly due to frontal lobe dysfunction disease, and (ii) a failure source monitoring central mechanism by which led trials. In Experiment 1, lesions controls were examined in same paradigm as used previously disease. Although able reduce their trials, not, instead showed...
Patients with mild Alzheimer's disease (AD) were compared age-matched control subjects on an associative recognition task. Subjects studied pairs of unrelated words and later asked to distinguish between these same (intact) new that contained either rearranged (rearranged) or non-studied (non-studied). Studied presented once 3 times. Repetition increased hits intact in both groups, but repetition false alarms only patients. This latter pattern indicates familiarity the pairs, able counter...
Clinical accounts of Alzheimer's disease (AD) suggest that some patients exhibit markedly diminished curiosity and initiative early in the course their illness. Such behavioral changes are extremely difficult to measure experimentally. We studied one aspect by measuring exploratory eye movements response provocative visual stimuli 12 with probable AD 10 matched controls. Subjects viewed slides, each which contained an incongruous or irregular figure paired a congruous regular one. Unlike...
Abstract A 42‐year‐old woman suffered two focal right hemisphere strokes, sequentially damaging different components of a proposed cerebral network for the spatial distribution attention. Her first stroke was centered in frontal lobe and resulted left hemispatial neglect but only tasks that emphasize exploratory‐motor directed second occurred 20 days later parietal led to emergence perceptual‐sensory aspects neglect. This case strongly supports existence distributed anatomic‐functional subserving
Abstract Despite the important role that attending to novel events plays in human behavior, there is limited information about neuroanatomical underpinnings of this vital activity. This study investigated relative contributions frontal and posterior parietal lobes differential processing target stimuli under an experimental condition which subjects actively directed attention events. Event-related potentials were recorded from well-matched patients, non-brain-injured who controlled their...
We employed positron emission tomography to examine the functional anatomy of exploratory-motor aspect spatial attention. Subjects moved their right hand under nonexploratory (control) versus exploratory (active) conditions. Movement architecture and eye movements were matched across Statistical parametric maps minus tasks in subjects using hemispace demonstrated activation cingulate, premotor posterior parietal areas. The net multiple hemisphere cortical areas ipsilateral active limb...
We treated a 62-year-old woman who developed dramatic change in personality and behavior following discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography single-photon emission computed tomography strongly implicated dysfunction ipsilateral lobe. This case further supports functional physiologic...
THIS study examined the relationship between orienting responses to novel events and subsequent exploratory behavior. The N2-P3 electrophysiologic component of response was found be larger for than repetitive background stimuli. Across subjects, amplitude this in frontal regions strongly predicted proportional increase duration viewing directed toward compared Within amplitudes stimuli were associated with longer durations on those These results suggest that reflects activity a neural system...
This study investigated the functional significance of N2 response to novel stimuli. In one condition, background, target, and deviant stimuli were simple geometric figures. a second all stimulus types unfamiliar/unusual third background target unusual figures shapes. Unusual figures, whether they deviant, or stimuli, evoked larger responses than their simple, familiar counterparts. elicited by an was that pattern opposite exhibited subsequent P3. Deviance from immediate context had limited...