A5101435442- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Dental Implant Techniques and Outcomes
- RNA regulation and disease
- Inflammasome and immune disorders
- dental development and anomalies
- Autophagy in Disease and Therapy
- Ginseng Biological Effects and Applications
- Gear and Bearing Dynamics Analysis
- Marine Sponges and Natural Products
- Orthodontics and Dentofacial Orthopedics
- Synthesis and Biological Activity
- Heat shock proteins research
- GDF15 and Related Biomarkers
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Pain Management and Opioid Use
- Acute Myocardial Infarction Research
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Fluoride Effects and Removal
East China Normal University
2018-2025
Daping Hospital
2019-2023
Army Medical University
2019-2023
Army Medical College
2022
Jilin University
2011-2022
Bridge University
2021
Zhejiang Normal University
2021
Chongqing Medical University
2012-2021
Shanxi Medical University
2018-2020
Second Affiliated Hospital of Nanchang University
2020
Nonalcoholic fatty liver disease (NAFLD) is characterized by accumulation of excessive triglycerides (TGs) in hepatocytes. Obesity a major risk factor for developing liver, although the intracellular molecular basis remains largely unclear. N6 -methyladenosine (m6 A) RNA methylation most common internal modification eukaryotic mRNA. In present study, m6 A sequencing and sequencing, we found that both enrichment mRNA expression lipogenic genes were significantly increased...
Anaplastic thyroid carcinoma (ATC) responds for the majority of death and often causes chemotherapy resistance.We investigated influence circEIF6 (Hsa_circ_0060060) on cisplatinsensitivity in papillary (PTC) ATC cells, explored its regulation to downstream molecules miR-144-3p Transforming Growth Factor α (TGF-α).Differentially expressed circRNAs PTC were analyzed using GSE93522 data downloaded.Expressions circEIF6, miR-144-3p, TGF-α, autophagyrelated proteins apoptosis-related determined...
Styrofoams are widely used as floats and likely to be damaged by burrowing animals in mariculture. However, the fate of fragmented their interaction with organisms not clear coastal environments. In present study, field investigations were conducted 14 sites along coast China from July 2023 October 2024. Results showed that buried sand or soil at a depth up 50–60 cm patchy belted distribution patterns. The abundances deep layer sediments ranged 94 3042 items/kg. bunched roots six plant...
Following the publication of this paper, it was drawn to Editors' attention by a concerned reader that certain β‑actin control data shown in western blots Fig. 3E on p. 6 were strikingly similar appearing different form other articles written authors at research institutes had already been published elsewhere prior submission paper Molecular Medicine Reports. Owing fact abovementioned apparently previously, Editor Reports has decided should be retracted from Journal. The asked for an...
Abstract Circulating miRNAs have attracted attention as serum biomarkers for several diseases. In this study, we aimed to evaluate the diagnostic value of circulating miRNA-21 (miR-21) a novel biomarker elderly patients with type 2 cardiorenal syndrome (CRS-2). A total 157 chronic heart failure (CHF) were recruited study. According an estimated glomerular filtration rate (eGFR) cut-off 60 ml/min/1.73 m , 84 (53.5%) and 73 (46.5%) assigned CRS group CHF group, respectively. Expression levels...
Long non-coding RNAs (lncRNAs) are important to the occurrence and advancement of human cancers. We found through GEPIA that LINC00893 was lowly expressed in thyroid carcinoma (THCA) tissues, whereas specific functions has never been reported PTC. In current study, we confirmed at a low level PTC cells. Through gain-of-function assays, determined overexpression abrogated proliferation migration abilities signal transduction reporter array potentially modulated signals phosphatase tensin...
Panax ginseng polysaccharides (GPS) are isolated from C. A. Meyer, which has many pharmacological activities. However, although the protective effect of GPS on inflammatory bowel disease (IBD) been characterized, its mechanism not yet fully elucidated. In present study, we clarified it IBD in mice and studied reducing inflammation. model was established by administrating dextran sulfate sodium (DSS) drinking water for 7 days. Our results showed that treatment significantly relieved activity...
Genomic aberrations are frequently found in anaplastic thyroid cancer (ATC). However, the functional genes aberrantly genomic regions largely unclear. In this study, we identified a long noncoding RNA (lncRNA) HOTAIRM1, whose encoding gene was amplified and expression upregulated ATC compared with papillary normal thyroid. Increased copy number of HOTAIRM1 were both correlated poor survival patients. Functional assays revealed that promoted proliferation, inhibited apoptosis, migration...
The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic subsequent to continuous opioid exposure. However, whether HDACs contribute the pathogenesis of BCP is still unknown. In current study, we explored possible engagement during BCP. After intra-tibia tumor cell inoculation (TCI), found increased expression was negatively correlated with decreased MOR DRG...
A chemical investigation of marine sponge Jaspis stellifera, collected from the South China Sea, led to isolation four new isomalabaricane-type triterpenoids, jaspiferins C–F (1–4). The structures those compounds were elucidated by extensive spectroscopic methods. Jaspiferin C (1), which has six-membered carbon ring at side chain, was discovered for first time triterpenoids. hypothesis a biogenetic pathway generate jaspiferin (1) depicted.
To study the therapeutic effect of Quyu (QY) Shengxin (SX) decoction (QYSXD) in mice with dextran sulfate sodium- (DSS-) induced ulcerative colitis and to investigate effects QYSXD on regulation receptor-interacting protein kinase 1 (RIP1)/receptor-interacting 3 (RIP3)/nucleotide-binding oligomerization domain-like receptor family pyrin domain (NLRP3) signaling pathway.Thirty-six were randomly divided into following 6 groups: experimental group (QYSX group), model (DSS positive control...
Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited efficacy. In this study, we investigated the potential application herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) based system inhibit chemoresistant AML cells. We first generated Ara-C resistant K562 and doxorubicin-resistant THP-1 found that HSV-TK/GCV anticancer suppressed drug leukemic in...
Abstract Background Correct torque of the incisors is beneficial in assessment effects orthodontic treatment. However, evaluating this process effectively remains a challenge. Improper anterior teeth angle can cause bone fenestrations and exposure root surface. Methods A three-dimensional finite element model maxillary incisor controlled by homemade four-curvature auxiliary arch was established. The placed on divided into four different state groups, among which 2 groups had tooth extraction...
A great number of children suffer from blast lung injury (BLI) worldwide, but there is a little basic study on the topic.Infant (4-week-old) and adult New Zealand rabbits were selected. Comparison BLI characteristics: 16 infant randomly divided into 4.0 MPa group (n = 8, "IRG4.0MPa") 4.5 "IRG4.5MPa") exposed to shock waves those magnitudes. Eight ("ARG4.0MPa"). The severity was compared among these three groups. impact characteristics between at same scale BLI: control 8 per age group) 40...
The main goals of surgery for fistula-in-ano are to completely resolve the condition and maintain optimal anal function. Effective management internal opening during proper postoperative drainage intersphincter plane crucial achieving successful outcomes. This study evaluated clinical efficacy a novel sphincter-sparing technique treating high transsphincteric fistula (HTAF).