A5100448631- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Methane Hydrates and Related Phenomena
- Oil Palm Production and Sustainability
- Environmental Toxicology and Ecotoxicology
- Protist diversity and phylogeny
- Peptidase Inhibition and Analysis
- Probiotics and Fermented Foods
- Meat and Animal Product Quality
- Gut microbiota and health
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
- Rangeland Management and Livestock Ecology
- Marine Bivalve and Aquaculture Studies
- bioluminescence and chemiluminescence research
- Antimicrobial Peptides and Activities
- Macrophage Migration Inhibitory Factor
- Neurobiology and Insect Physiology Research
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Microbial Metabolism and Applications
University Medical Centre Mannheim
2025
Beijing Tongren Hospital
2023-2025
Capital Medical University
2023-2025
Heidelberg University
2025
University Hospital Heidelberg
2025
South China Normal University
2025
Qingdao National Laboratory for Marine Science and Technology
2017-2024
Affiliated Hospital of Southwest Medical University
2024
Meizhou City People's Hospital
2024
Eye Center
2024
53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers. Intra-chromosomal DNA double-strand break (DSB) events during immunoglobulin class switch recombination (CSR) require 53BP1. However, cells, blocks homologous (HR) and promotes toxic NHEJ, resulting genomic instability. Here, we identify the protein dimerization hub-DYNLL1-as an organizer of multimeric complexes. DYNLL1 binding stimulates...
Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres genome-wide. We previously showed binds disrupts G-quadruplex (G4) in vitro, suggesting may prevent vivo blocks to by resolving G4 structures. Here, we demonstrate unfolds similar efficiency RPA. In cells, recruited telomeric non-telomeric chromatin upon stabilization, even when ATR/ATM pathways were inhibited. STN1 depletion increases...
Abstract Candidatus Izemoplasma, an intermediate in the reductive evolution from Firmicutes to Mollicutes, was proposed represent a novel class of free-living wall-less bacteria within phylum Tenericutes. Unfortunately, paucity pure cultures has limited further insights into their physiological and metabolic features as well ecological roles. Here, we report first successful isolation Izemoplasma representative deep-sea methane seep, strain zrk13, using DNA degradation-driven method given...
The discovery of topological edge states that unidirectionally propagate along the boundary system without backscattering has enabled development new design principles for material or information transport. Here, we show flow supported by chiral active fluid composed spinners can even robustly transport an immersed intruder with aid spinner-mediated depletion interaction between and boundary. Importantly, effective significantly depends on dissipationless odd viscosity fluid, which...
Background: To explore the hub gene closely related to progression of gastric cancer (GC), so as provide a theoretical basis for revealing therapeutic mechanism GC.Methods: The expression profile and clinical data GSE15459 in Gene Expression Omnibus (GEO) database were downloaded.The weighted co-expression network analysis (WGCNA) was used screen key modules GC progression.Survival assess influence genes on patients' outcomes.CIBERSORT predict tissue infiltrating immune cells...
Abstract. The Landsat series constitutes an unparalleled repository of multi-decadal Earth observations, serving as a cornerstone in global environmental monitoring. However, the inconsistent coverage data due to its long revisit intervals and frequent cloud cover poses significant challenges land monitoring over large geographical extents. In this study, we developed full-chain processing framework for multi-sensor fusion Landsat-5, 7, 8, 9 MODIS Terra surface reflectance products. Based on...
Bacterial motility is a crucial factor during the invasion and colonization processes of pathogens, which makes it an attractive therapeutic drug target. Here, we isolated marine bacterium (Vibrio alginolyticus strain 178) from seamount in tropical West Pacific that exhibits vigorous on agar plates severe pathogenicity to zebrafish. We found V. 178 was significantly suppressed by another bacterium, Bacillus sp. 176, same niche. isolated, purified, characterized two different cyclic...
Summary Bacteroidetes are thought to be specialized for the degradation of algae‐derived ocean polysaccharides. Here, we show that predominant phylum in deep‐sea sediments and possess more genes associated with polysaccharides than other bacteria. We have isolated a novel species from by using special polysaccharide containing medium, Maribellus comscasis WC007, which possesses 82 putative utilization loci (PULs) 374 glycoside hydrolases SusC/D pairs (Sus indicates s tarch u tilization...
Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation. Identifying molecular is challenging. There scarcity of target-specific upregulating glues, which highly anticipated for numerous targets, including P53. P53 degraded in proteasomes through polyubiquitination by specific E3 ligases, whereas deubiquitinases (DUBs) remove conjugates counteract these ligases. Thus,...