A5100601366- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Advanced Biosensing Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Supramolecular Self-Assembly in Materials
- Cancer-related Molecular Pathways
- Nuclear Receptors and Signaling
- Endoplasmic Reticulum Stress and Disease
- Memory and Neural Mechanisms
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Fungal Biology and Applications
- Plant tissue culture and regeneration
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
Hebei University of Science and Technology
2025
Second Affiliated Hospital of Nanchang University
2024-2025
Nanchang University
2024-2025
State Key Laboratory of Medical Neurobiology
2019-2024
Chengde Medical University
2023-2024
Fudan University
2019-2024
Huashan Hospital
2019-2024
Shanghai Jiao Tong University
2020-2023
Jiaxing University
2023
Jinan University
2020-2023
Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-targeting chimeras) provides promising therapeutic strategies, but selective degradation of non-protein biomolecules has been challenging. Here, we demonstrate a novel strategy to degrade autophagy-tethering compounds (ATTECs), using lipid droplets (LDs) an exemplar target. LDs are ubiquitous cellular structures storing lipids and could be degraded autophagy. We hypothesized that interacting with both the key...
Although emerging evidence suggests that the pathogenesis of Parkinson's disease (PD) is closely related to aggregation alpha-synuclein (α-syn) in midbrain, clearance α-syn remains an unmet clinical need. Here, we develop a simple and efficient strategy for fabricating nanoscavenger PD via reprecipitation self-assembly procedure. The curcumin analogue-based (NanoCA) engineered be capable controlled-release property stimulate nuclear translocation major autophagy regulator, transcription...
Abstract: TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, considered to be new therapeutic target for Parkinson's disease (PD). However, only several small-molecule activators have been discovered their neuroprotective effects in PD are unclear. In this study, curcumin derivative, named E4, was identified as potent activator. Compound E4 promoted the translocation from cytoplasm into nucleus, accompanied by enhanced lysosomal biogenesis....
Abstract Background Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for treatment chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone and explore underlying mechanisms. Methods Rat model was this study. withdrawal threshold evoked by stimulation hindpaw determined using a 2290 CE electrical von Frey hair. β-endorphin IL-10 levels were measured spinal cord cultured primary microglia,...
This study aimed to detect early changes in left ventricular systolic function Beagle dogs after radiotherapy using two-dimensional speckle tracking echocardiography and explore its potential value evaluating radiation-induced heart disease. Thirty-six were randomized into a control group (n = 18) an irradiation 18). The received single dose of 20 Gy the anterior wall, while controls underwent sham irradiation. Conventional 2D performed at baseline 3, 6, 12 months post-procedure....
Cell senescence deters the activation of various oncogenes. Induction is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate receptor 1 (S1PR1) has been implicated cancer types, including ovarian cancer. The mechanism by which S1PR1 regulates cell is currently elusive. In this study, we demonstrate that was highly expressed human tissues and lines. deletion inhibited proliferation migration promoted sensitized cells cisplatin...
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β (Aβ) and hyper-phosphorylated tau accumulation are accountable for progressive neuronal loss cognitive impairments usually observed in AD. Currently, medications AD offer moderate symptomatic relief but fail to cure disease; hence development of effective safe drugs urgently needed treatment. In this study, we investigated a Chinese medicine (CM) formulation named NeuroDefend (ND), reducing amyloid...
Chitosan, behaving as a potent biotic elicitor, can induce plant defense response with the consequent enhancement in phytoalexin accumulation. Accordingly, chitosan elicitation was conducted to promote production of two phytoalexins, i.e. formononetin and calycosin (also known health-promoting isoflavones), Astragalus membranaceus hairy root cultures (AMHRCs). Compared control, 12.45- 6.17-fold increases yields (764.19 ± 50.81 μg/g DW) (611.53 42.22 were obtained 34 day-old AMHRCs treated by...
Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains deadly disease. New targeted treatment options are urgently needed. PSMA is highly expressed in has been an attractive biomarker for the of cancer. In this study, we explored feasibility delivery antimitotic drug, monomethyl auristatin E (MMAE), to tumor tissue using small-molecule based lig-and. With aid Cy5.5, found that cleavable linker vital antitumor activity ligand-drug...
Abstract In the recent issue of Nature Communications (2023 Nov 30;14(1):7908), Xue et. al. reported a very interesting and significant discovery possible DCAF11 ligand chemotype that could be used as “warhead” to design bifunctional compounds for targeted degradation via engaging E3 ligase 1 (annotated ref hereafter). The is importance protein field was inspired by previous reports suggesting similar may also engage autophagosome LC3 function autophagy-tethering (ATTECs) 2, 3, 4, 5, 6, 7 ,...
Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation. Identifying molecular is challenging. There scarcity of target-specific upregulating glues, which highly anticipated for numerous targets, including P53. P53 degraded in proteasomes through polyubiquitination by specific E3 ligases, whereas deubiquitinases (DUBs) remove conjugates counteract these ligases. Thus,...