A5100602592- Plant Pathogens and Fungal Diseases
- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect and Pesticide Research
- Immune cells in cancer
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Plant-Microbe Interactions and Immunity
- Exercise and Physiological Responses
- Vascular Procedures and Complications
- Immune Response and Inflammation
- Insect Pest Control Strategies
- Kruppel-like factors research
- Circadian rhythm and melatonin
- Retinoids in leukemia and cellular processes
- melanin and skin pigmentation
- Heat shock proteins research
- Hormonal Regulation and Hypertension
- Glutathione Transferases and Polymorphisms
- Hippo pathway signaling and YAP/TAZ
- Neurological Disease Mechanisms and Treatments
- Aldose Reductase and Taurine
- Insect Utilization and Effects
Shaanxi Normal University
2025
Yangzhou University
2025
University of Electronic Science and Technology of China
2024
Jiaxing University
2022-2023
South China Agricultural University
2023
Heilongjiang Bayi Agricultural University
2023
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2022
Hong Kong Polytechnic University
2022
Nanjing Drum Tower Hospital
2022
Nanjing University
2020-2022
Intestinal fibrosis is induced by excessive myofibroblast proliferation and collagen deposition, which has been regarded as a general pathological feature in inflammatory bowel disease (IBD). Therefore, identifying clinical markers targets to treat prevent intestinal urgently needed. The traditional Chinese medicine maggot, commonly known “wu gu chong”, shown reduce oxidative stress alleviate inflammation chronic colitis. This study investigated the mechanisms underlying effects of maggot...
Excessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the induced follicular developmental disorder is major cause infertility women with polycystic ovary syndrome (PCOS). Exercise-induced upregulation irisin capable regulating metabolism by reducing OS inflammation. Exercise has been shown to alleviate a range PCOS symptoms, including maintaining normal menstrual cycle, several clinical trials.Female...
Cell senescence deters the activation of various oncogenes. Induction is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate receptor 1 (S1PR1) has been implicated cancer types, including ovarian cancer. The mechanism by which S1PR1 regulates cell is currently elusive. In this study, we demonstrate that was highly expressed human tissues and lines. deletion inhibited proliferation migration promoted sensitized cells cisplatin...
Objective To examine the prognostic values of systemic immune-inflammation indices hemodialysis (HD) vascular access failure and develop a prediction model for based on most pertinent index. Study design A prospective cohort study. Setting & participants Patients undergoing autogenous HD surgeries or arteriovenous graft as permanent in tertiary center southwest China from January 2020 to June 2022. Predictors Systemic indices, including NLR, dNLR, AAPR, SIRI, SII, PNI, PLR, LIPI,...
Combining diet with exercise can improve health and performance. Exercise reduce androgen excess insulin resistance (IR) in polycystic ovary syndrome (PCOS) patients. Curcumin is also presumed to the follicle development disorder. Here, we investigated effects of a combination therapy oral intake curcumin on hyperandrogen-induced endoplasmic reticulum (ER) stress ovarian granulosa cell (GC) apoptosis rats PCOS. We generated PCOS model via continuous dehydroepiandrosterone subcutaneous...
Hyperandrogenism is a common characteristic of polycystic ovary syndrome (PCOS). Long-term, continuous exposure to hyperandrogenic environments may cause excessive endoplasmic reticulum (ER) stress in ovarian granulosa cells (GCs). Curcumin polyphenol extracted from turmeric rhizomes which has several pharmacological effects that benefit patients with PCOS. To explore whether curcumin can inhibit hyperandrogen-induced ER GCs PCOS rats and elucidate the possible underlying mechanisms. We...
Cisplatin resistance is a crucial factor affecting ovarian cancer patient’s survival rate, but the primary mechanism underlying cisplatin in remains unclear, and this prevents optimal use of therapy. Maggot extract (ME) used traditional Chinese medicine for patients with comas gastric when combined other drug treatments. In study, we investigated whether ME enhances sensitivity cells to cisplatin. Two cells—A2780/CDDP SKOV3/CDDP—were treated vitro. SKOV3/CDDP that stably expressed luciferase...
Ovarian cancer is one of the most lethal gynecological malignancies, because metastatic dissemination with poor late clinical therapy. Maggots have been used in traditional Chinese medicine, where they are also known as ‘Wu Gu Chong’. Previous studies indicated that maggot extract (ME) was beneficial for treatment gastric when combined other drugs, but effect on anti-ovarian and underlying mechanism remains unclear. The aim this study to investigate effects ME suppressing proliferation...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women. Moderate aerobic exercise intervention considered an initial treatment strategy for managing PCOS. Brain-derived neurotrophic factor (BDNF) important molecular mediator and beneficial response to exercise. We aimed investigate the expression pattern underlying mechanisms of this during follicle development in ovarian tissues. The PCOS model was established by subcutaneous injection 60 mg/kg dehydroepiandrosterone...
Blast, caused by Magnaporthe oryzae, is one of the most destructive diseases affecting rice production. Understanding population dynamics pathogen avirulence genes pre-required for breeding and then deploying new cultivars carrying promising resistance genes. The divergence structure AvrPii was dissected in populations southern (Guangdong, Hunan, Guizhou) northern (Jilin, Liaoning, Heilongjiang) China, via genetic evolutionary approaches. between a known haplotype AvrPii-J novel AvrPii-C...
Blast, caused by Magnaporthe oryzae, is one of the most destructive diseases affecting rice production. Understanding population dynamics pathogen’s avirulence genes pre-required for breeding and then deploying new cultivars carrying promising resistance genes. The divergence structure AvrPii was dissected in populations southern (Guangdong, Hunan, Guizhou) northern (Jilin, Liaoning, Heilongjiang) China, via genetic evolutionary approaches. between a known haplotype AvrPii-J novel AvrPii-C...
Inositol 1, 4, 5-trisphosphate (IP3) signaling-mediated calcium release drives the contraction of vascular smooth muscles and hence regulates blood vessel volume pressure. Melatonin supplementation has been suggested to be beneficial for hypertension. To determine whether pressure-lowering effect melatonin was accounted by IP3 signaling, we evaluated vasoconstriction response signaling in isolated mouse thoracic aortic rings during incubation. C57BL/6 mice were given intraperitoneal...
Abstract Exercise, as an effective non-drug intervention, plays important role in preventing and alleviating several diseases. Endoplasmic reticulum (ER) stress is caused by excessive accumulation of unfolded or misfolded proteins the ER also serves body’s internal self-protection mechanism. occurrence can be detected cells many diseases such cancer, diabetes, obesity, osteoporosis, neurodegenerative diseases, metabolic In recent years, exercise has been suggested to change molecular...
Objective To investigate the effect of sertraline on viability and expression tyrosine hydroxylase (TH) phosphorylated ERK1/2 in NGF-induced rat pheochromocytoma (PC12) cells.Methods PC12 cells were pretreated or directly treated with different concentrations for 24 48 hours groups then subjected to serum withdrawal condition. Then cell was determined by counting Kit-8 (CCK-8). The Tyrosine pERK1/2in immunohistochemistry western blot respectively. Results improved after administration...
Abstract Background Excessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the induced follicular developmental disorder is major cause infertility women with polycystic ovary syndrome (PCOS). Exercise-induced upregulation irisin capable regulating metabolism by reducing OS inflammation. Exercise has been shown to alleviate a range PCOS symptoms, including maintaining normal menstrual cycle, several clinical...